We are looking for a highly motivated doctoral researcher to join the 3-year period ImmuDocs Doctoral Education Pilot project “Macrophages and neutrophils in cancer progression”, led by Professor Jyrki Heino, University of Turku.
Project description:
Malignant tumours consist of transformed cancer cells and of numerous other cell types including cancer associated fibroblasts (CAFs), tumour associated macrophages (TAMs), neutrophils, lymphocytes and endothelial cells. All cell types regulate each others’ phenotype and behaviour and cancer progression. Extracellular matrix (ECM) – mainly produced by CAFs – is an important component of the tumour microenvironment. ECM has a major impact on cancer cells, on the efficacy of immunotherapies and finally on the disease outcome.
We have developed new 3D spheroid-based methods to study the interactions of different cell types: human cutaneous squamous cellular carcinoma (cSCC) cells, CAFs and TAMs/neutrophils. Using e.g. mass spectrometry, RNA-sequencing, microscopy and cellular assays for proliferation, phenotype/plasticity and invasion the project aims to unveil the TAM and neutrophil based regulatory mechanisms of invasion and ECM remodelling. Furthermore, our preliminary results have revealed the remarkable plasticity of TAMs. The project aims to find molecular mechanisms used by CAFs and cSCC cells to regulate TAM phenotype.
In our recent paper we showed that the spheroid model can be used to successfully screen potential drug molecules (Siljamäki et al., Oncogene, 2023. PMID: 37864034). In this doctoral project the spheroids containing three different cell types will be used to test the effects of the inhibitors of critical signalling pathways. The model also allows testing of putative drug molecules targeted to macrophages and neutrophils.
Finally, we have recently established a method to combine laser capture microscopy to mass spectrometry and shown that it is possible to get detailed information about e.g. ECM composition in different tumour areas of paraffin embedded SCC tumours and their metastases. This in vivo information is critical for interpretation of the results from in vitro experiments focused on the effects of macrophages and neutrophils on the composition and organization of the ECM.
Orion’s Immuno-Oncology (IO) research team is looking to recruit an enthusiastic and motivated Immunology and flow-cytometry scientist to join the IO team. In this role you will contribute to IO target identification and validation, coupled with being responsible for supporting multi colour flow cytometry needs. In this role you have a unique opportunity to contribute in a range of treatment modalities ranging from small molecules, large molecules (bispecific & monospecific antibodies) and CAR T cells.
The responsibilities of this role include the following (including, but not limited to);
Design and perform in vitro immune assays and treatment with oncology drugs in conjunction with internal project teams.
Desing multi-colour flow cytometry antibody panels to detection and FACS sorting of a range of Immune cells.
Establish and validate human and mouse in vitro primary immune cells assays to define the mechanism of action of IO drugs.
Co-ordinate with the line-manager to ensure timely delivery of data and report if any issues encountered or foreseen.
Be responsible person for flow cytometry training for internal staff and regular maintenance of flow cytometry and cell sorter instruments.
Provide clear reports and presentations as required and participate in project team meetings and organisation meetings.
Working in close collaboration with other scientists and technicians.
This is a fixed-term contract of employment (parental leave) and location is Turku, Finland.
Description Of Unit
Immuno-Oncology (IO) is one of the three Research teams in Orion’s Oncology R&D. IO team is accountable for novel drug discovery projects, identification of unmet need, identification & experimental validation of potential IO drug targets within state-of-the-art laboratories and technologies.
We Offer
We offer you the opportunity to show your talent in one of the most innovative* companies in Finland. You get a chance to work in a challenging field of work with excellent colleagues. You will also have the chance to do meaningful work and build the future of Orion. We are striving for excellence in everything we do. We succeed, learn together and appreciate each other. You’ll be empowered to deliver value. Please visit our website to find further information about Orion as an employer.
Requirements
To be a successful ideally you should have the following educational and professional work experiences:
PhD degree in Immunology or related field with 2+ years of relevant experience.
Strong and deep knowledge building multi colour panels, flow cytometry and cell sorter instruments
Strong in vitro research experience using primary immune cells assays is a must
Demonstrate ability to independently design, conduct and interpret the data from complex in vitro immune cell assays and flow cytometry is a must.
Demonstrate proficiency in isolation of immune cells and processing samples for multi-colour flow cytometry, multiplex ELISA, IHC, single cell RNA sequencing and gene expression analysis.
Competency in using graph pad prism, flowjo, nSolver software and other standard office software.
Excellent attention to details with strong communication skills.
Flexibility and willingness to learn new techniques and take additional responsibilities as a member of the research team.
Additional Information
We look forward to hearing from you as soon as possible, so please send your application in English by 10th March at the latest.
For further information, please contact Dr Anil Thotakura, Head of Immuno-oncology, +358 50 966 7229 on 28th Feb 4:00 to 5:00pm or 4th March 4:30 to 5:30pm or 7th March 4:00 to 5:00pm
Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person. Orion Corporation operates in more than 30 countries, where we Orionees, 3600 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.
Suomen Solubiologit ry järjestää kesätyönhakuwebinaarin! Webinaarin aikana kuulemme Eurofins Environment Testing Finlandin yritysesittelyn sekä kesälle 2024 tarjolla olevien työpaikkojen esittelyn. Tilaisuuden osallistujilla on myös mahdollisuus esittää kysymyksiä Eurofinsin edustajille.
Webinaarin tiedot:
Päivänmäärä: Maanantai 11.3.2024
Aika: Klo 15-16
Paikka: Zoom
Kieli: Suomi (Eurofinsin työkieli on suomi)
Miksi osallistua?
Kuulet lisää Eurofinsin tarjolla olevista kesätyöpaikoista
Pääset tutustumaan Eurofins-yritykseen laajemmin – entä mitä työllistymismahdollisuuksia on Suomen ulkopuolella?
Pääset esittämään kysymyksiä henkilökohtaisesti Eurofinsin edustajille
Saat vinkkejä ja ohjeita onnistuneeseen työnhakuprosessiin
Varmista siis paikkasi tässä webinaarissa ja tule kuuntelemaan minkälaisia teollisuus- ja ympäristölaboratorioalan kesätöitä Eurofins Environment Testing Finlandilla on tarjota!
We are delighted to invite you to the celebration of our society’s 50th anniversary on 15th of March 2024 in Jyväskylä, Ambiotica, Survontie 9c! This special day will be filled with exploring cutting-edge science and timely topics with your colleagues from across Finland, and a delightful anniversary dinner with live music.
Date: Friday 15th of March Time: Society annual meeting 12:00pm Anniversary seminar: 2:00pm – 6:00pm Anniversary dinner: 6:00pm
Venue: Ambiotica Lecture Hall YAA303, Ylistönrinne Survontie 9c, 40500 Jyväskylä
Anniversary seminar theme: Towards smarter care and health innovations using cell biology
Seminar sessions: 1. Challenges of health communication Speakers: Tuomas Aivelo (University of Helsinki), Pauli Ohukainen (Tervettä Skeptisyyttä Oy, Oura Health) 2. Artificial intelligence in cell biology research and healthcare Speakers: Leena Latonen (University of Eastern Finland), Lassi Paavolainen (Institute for Molecular Medicine Finland), Juha Väyrynen (University of Oulu) 3. Young scientists as future pioneers in cell biology Speakers: Sonja Koivukoski (University of Eastern Finland), Veera Luukkonen (Åbo Akademi)
Anniversary dinner: Start time: 6:00pm Venue: Ravintola Ylistö, YFL-building, Survontie 9c, 40500 Jyväskylä Dress code: Smart casual Dinner price: 25€, 15€ for students and society members
Dinner menu: Starter: Mixed green salad with pomegranate and lemon vinaigrette Seasonal kale with herbs and pine nuts Ricotta ravioli with cherry tomatoes and spinach Spelt and beetroot salad Smoked vendace and potato salad
Main course: Slow-cooked beef cheek with blackcurrant-infused red wine sauce Roasted garlic-rosemary tomatoes and vegetables
Dessert: Raspberry-white chocolate cake
Please specify any allergies or food restrictions when registering!
Osallistu Suomen Solubiologit ry:n haalarimerkkikilpailuun!
Suomen Solubiologit ry juhlii tänä vuonna 50-vuotista taivaltaan, ja haluamme juhlistaa merkittävää vuosipäivää uuden, upean haalarimerkin avulla! Vanhat haalarimerkkimme ovat loppuneet, joten etsimme nyt luovia jäseniämme ja seuraajiamme suunnittelemaan seuraavaa merkkiä yhdistyksellemme.
Kilpailuohjeet:
Suunnittele haalarimerkki, joka kuvastaa Suomen Solubiologit ry:tä, ja mahdollisesti sen 50-vuotista taivalta.
Lähetä suunnittelemasi haalarimerkkikuva sähköpostitse osoitteeseen suomensolubiologit@gmail.com viimeistään 29.2.2024 mennessä.
Palkinnot:
Voittaja saa vuoden ilmaisen jäsenyyden ja oman suunnittelemansa haalarimerkin.
Vaihtoehtoisesti voittaja voi valita ilmaisen illallisen yhdistyksemme 50-vuotisjuhlatapahtumassa Jyväskylässä 15.3.2024.
Osallistu nyt ja ota osaa juhlavuoteemme!
**
Join The Finnish Society for Cell Biology Patch Design contest!
The Finnish Society for Cell Biology celebrates its 50th anniversary this year, and we want to commemorate this milestone with a brand new patch! Our old patches are out of stock, so we’re calling our creative members and followers to design a new patch for our society.
Contest guidelines:
Design a patch that represents The Finnish Society for Cell Biology, and perhaps its 50 years of history.
Tampere University and Tampere University of Applied Sciences create a unique environment for multidisciplinary, inspirational and high-impact research and education. Our universities community has its competitive edges in technology, health and society. www.tuni.fi/en
The Centre of Excellence in Body-on-Chip Research (CoEBoC) is a multidisciplinary research consortium combining cell biology and engineering and aims at developing body-on-chips to model human tissue function. The center has multidisciplinary expertise on human stem cells, biomaterials, sensors, microfluidics, biomodeling and bioimaging. CoEBoC produces new comprehensive knowledge on understanding tissue interactions, constructing complex in vitro tissue co-cultures and controlling their functionalities. The resulting expertise and technologies will improve for example development of disease modeling, new personalized treatments and drug development.
Job description
We are looking for 6-16 Research Assistants to work on research and development projects within multidisciplinary research consortium. The open positions are related to ongoing research projects of CoEBoC concentrating on stem cells, cell differentiation, molecular biology, 3D culturing, biomaterials, sensors technology, microfluidics, microfluidic chips, biomodeling or bioimaging.
Requirements
Candidates of all higher education levels with more than one year of studies are welcome to apply. The position requires basic knowledge of the CoEBoC’s research areas and good English communication skills.
Tampere University is a unique, multidisciplinary, and boldly forward-looking community. Our values are openness, diversity, responsibility, courage, critical thinking, and learner-centeredness. We hope that you can embrace these values and promote them in your work.
We offer
The position will be full-time/part-time and it will be filled for a fixed-term period of three months starting preferably in May-June 2024. A trial period applies to all our new employees.
The salary will be based on both the job demands and the employee’s performance following the University Salary System. The position of Research Assistant is placed on the job demand level 1 (the demand level chart for the teaching and research staff). In addition, employees will receive a performance-based salary which for Research Assistants is based on their study credits.
We offer a wide range of staff benefits, such as occupational health care, flexible working hours, excellent sports facilities on campus and several restaurants and cafés on campus with staff discounts. Please read more about working at Tampere University.
We are inviting you to be a part of a vibrant, active and truly international research community. Interdisciplinarity is highly encouraged, as it allows you to expand your research network and exposes you to new perspectives and ideas to solve complex research problems and pursue novel research findings. We have a strong commitment to the highest level of scientific research and the provision of high-quality doctoral education.
How to apply
Please submit your application through our online recruitment system (link below). Please note that you will need to choose your preferred research groups (1-3) in the online application. The closing date for applications is January 31st, 2024 (at 23:59 EET / UTC +2). Applications and all accompanying documentation should be written in English, and attached in PDF format. Please note that applicants may be invited to participate in an interview throughout the application time and therefore we encourage you to apply as soon as possible. We are aiming to make the decisions by March 15th, 2024.
Applications should include the following documents:
Curriculum Vitae
Transcript of studies
Motivation letter that includes your preferred choices (1-3) for the research group:
Adult Stem Cell Group
Biomaterials and Tissue Engineering Group
Computational Biophysics and Imaging Group
Heart Group
Micro- and Nanosystems Group
Neuro Group
A copy of the possible bachelor’s degree
For more information, please contact: coordinator, Miina Björninen, email: miina.bjorninen@tuni.fi.
***
Tampereen yliopisto ja Tampereen ammattikorkeakoulu muodostavat yhdessä Suomen toiseksi suurimman monitieteisen, innostavan ja vaikuttavan tutkimus- ja oppimisyhteisön. Korkeakouluyhteisömme osaamiskärjet ovat tekniikka, terveys ja yhteiskunta. Lue lisää: www.tuni.fi
Monikudosmallintamisen huippuyksikkö on kuuden Tampereen yliopistossa toimivan tutkimusryhmän muodostama poikkitieteellinen tutkimuskeskus. Huippuyksikkömme tavoitteena on yhdistää teknologisten ja biologisten tieteiden osaamista uudenlaisen body-on-chip -konseptin kehittämiseksi. Body-on-chipillä tarkoitetaan soluviljelylaitteistoa, jossa itse soluviljelmien lisäksi on tekniikkaa solujen stimuloimiseksi sekä toiminnan monitoroimiseksi. Laitteisto on yleensä rakennettu mikrofluidististen alustan päälle, joka mahdollistaa automatisoidun soluviljelynesteen kierrättämisen sekä mahdollisen lääkeainesyötön. Huippuyksikkömme tavoitteena on rakentaa ihmiskehon toimintoja jäljittelevä monikudosmalli ihmisen kudosten perusbiologian tutkimiseen sekä systeemisten sairauksien että traumojen mallintamiseen.
Tehtävänkuvaus
Tutkimusapulaisen tehtävät muodostuvat erilaisista monikudosmallintamiseen liittyvistä laboratoriotyötehtävistä.
Hakuohjeet
Lue tarkemmat tiedot tehtävästä ja hakuohjeet yllä olevasta englanninkielisestä ilmoituksesta.
Jätäthän hakemuksesi yliopiston sähköisellä hakulomakkeella (linkki löytyy tämän ilmoituksen alta). Hakuaika tehtävään päättyy 31.1.2024 klo 23.59. Haethan tehtävään mahdollisimman pian, sillä hakemuksia käsitellään ja haastattelukutsuja lähetetään mahdollisesti jo hakuaikana.
Are you interested in development of biobased surfactants and looking for a new job opportunity in the field? Would you like to do impactful research in the cutting edge of natural sciences with superb colleagues who are top experts in their field? Do you want to build a science career and work in a versatile role at the interface of academy and industry? VTT might be just the place for you.
VTT is one of the leading applied research organisations in Europe. What unites us are curiosity, a passion for learning, and a purpose: to solve the biggest challenges of our time and turn them into sustainable growth and well-being. Our cross-disciplinary community of over 2000 brilliant minds focuses on creating impact through science-based innovation. In recent years, we have created ground-breaking innovations such as the world’s fastest and most accurate radiation detector, a cancer-sniffing sensor device for smartphones, and a headphone set entirely made of microbial materials. Get to know us further by exploring VTT’s tech & infra .
We are now looking for a PhD student to join our Production host engineering team.
As a PhD student, you have an opportunity to focus on research towards PhD degree under the supervision of experienced professionals and to develop our lipid platform, which serves as a core technology for multiple industries from food to pharma and fuel. The main fields of research include yeast physiology, metabolic engineering, genetic engineering and synthetic biology. In this position, you will have the opportunity to learn about fungal metabolism and physiology especially in context of surfactant production. You will use up-to-date synthetic biology tools, analytical methods, and cultivation technologies. Computational biology, data management, and automation are incremental parts of the work.
As a Doctoral researcher at VTT, you are able to make an impact on our customers and society. Our researchers work closely together with industry, often in interdisciplinary research groups. VTT has excellent research infrastructure and internal services to support your research work. VTT has also started a Doctoral Programme to support goal-oriented PhD work within VTT’s strategic research choices. Once you have completed your PhD, we offer an exciting career opportunity with emphasis on applied research, working closely with our customers.
Our team, Production host engineering works on metabolic engineering of large number of known and non-conventional fungal hosts for production of various products e.g., lipids and derivatives, organic acids, colourants, or flavours and fragrances. We contribute to current and future production methods of food compounds and ingredients in cellular agriculture, chemicals and small molecules and materials.
Learn more about our research:
Microbial pigments
As a PhD student, you will:
Conduct scientific project work in the fields of metabolic engineering and synthetic biology for generation of surfactants
Actively participate in a multi-disciplinary research team to form research ideas and technical solutions to execute them
Participate in discussions with industry to help solve their challenges
Who we are looking for:
Completed MSc in relevant field such as biochemistry, genetics, or microbiology
Excellent laboratory skills and experience in molecular biology techniques
Experience working either with bacteria, yeast or filamentous fungi
Strong spoken and written English skills
It’s a benefit if you have experience with biochemistry, chemistry, and/or computational methods
As a person, we hope that you are:
Motivated and willing to take initiative in getting projects accomplished with a “can do” attitude
Able to work both independently and as a member of a team
Curious towards cross-disciplinary approaches and technological challenges
Willing to conduct part of the project in a collaborator’s laboratory in Sweden
You are target-driven both with your decision-making and in learning new things and growing professionally
With VTT, you’ll enjoy:
Natural sciences with an impact. VTT works on the cutting-edge of natural sciences, and we’ve invested in building state-of-the-art research facilities for natural sciences, such as the Bioruukki pilot infrastructure for bio- and circular economy. Our research agenda is dedicated to solving systemic and technological challenges, such as reaching carbon neutrality and unleashing the power of synthetic biology. That means that at VTT, your expertise in natural sciences will go towards creating a real impact. Read more about our strategy – the path of exponential hope .
Superb colleagues and community. With VTT, you’ll join a community of over 2000 multidisciplinary experts who foster a culture of trust, openness, and sharing of knowledge. We work across disciplines and house all the cutting-edge sciences, from quantum computing to synthetic biology, under one roof. Collaborating with superb colleagues is a source of learning, inspiration, and fun. Read more about our organisational culture as the builder of the world’s most meaningful place to work.
Excellent career in research. At VTT, excellence in research is a strategic priority. We offer long-term positions and stable career paths in top-level research. People tend to stay with us for over ten years since there are always new roles and responsibilities to grow into. A combination of cutting-edge academic research and applied customer projects keeps your career path interesting.
Support for your well-being. Our people are our main asset, so we take good care of them. We aim to nurture excellent team spirit and leadership and offer versatile well-being services to enable a good work-life balance. On top of 6 weeks of paid holidays, we offer exercise and culture benefits, hobby clubs, and voluntary well-being services such as meditation and cognitive ergonomics training.
Apply now and join our community of brilliant minds!
Please send your CV and answer to the preliminary screening questions with your salary request via our recruitment system as soon as possible but at the latest by 18th of January 2024. We will make our first screening anonymously based on the answers you have provided to the open questions and we will process applications as they come in and fill the position as soon as we find the right candidate. A security clearance procedure may be conducted during the recruitment process.
Interested and want to know more?
For further information, please contact Principal scientist Peter Richard, peter.richard@vtt.fi, +358405186027 or Research Team Leader Mervi Toivari, mervi.toivari@vtt.fi, +358407081039 on 12th or15th of January at 1-3 pm.
We look forward to hearing from you!
VTT
VTT is a visionary research, development and innovation partner. We drive sustainable growth and tackle the biggest global challenges of our time and turn them into growth opportunities. We go beyond the obvious to help the society and companies to grow through technological innovations. We have 80 years of experience of top-level research and science-based results. VTT is at the sweet spot where innovation and business come together.
The Evolution, Conservation, and Genomics research group, led by Professor Craig Primmer ( https://www.helsinki.fi/en/researchgroups/evolution-conservation-and-genomics ),
is looking for a
RESEARCH TECHNICIAN/LABORATORY COORDINATOR (Genomics and molecular biology)
for the period of 1.2.2024 – 31.12.2025 (the starting date can be negotiated) to assist an international team in conducting molecular biology and genomic analyses e.g. DNA and RNA extraction, next-generation sequencing (e.g. bulk and single-cell RNA-seq), targeted SNP assay development and analysis, cell biology and histology techniques. Additional tasks may include ordering reagents, database maintenance, helping maintain experimental Atlantic salmon and rainbow trout populations, measuring and sampling fish and assisting other lab members as needed.
The successful candidate will likely have experience with at least some of the above-mentioned techniques and be enthusiastic about learning others. They will mainly work under the supervision of post docs and/or PhD students .We are looking for a highly motivated candidate with excellent organizational skills and good English communication skills. We appreciate a cooperative attitude and enthusiasm for learning new techniques and skills.
The salary is based on levels 6-8 of the job requirement scheme for other personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal work performance. The position is offered with a six-month trial period.
Applicants are requested to submit their application, as one single pdf file, which includes the following documents:
CV including contact details for at least 2 referees
motivation letter (max 1 page).
The application must be submitted through the University of Helsinki electronic recruitment system by clicking on Apply for the position. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal. The closing date for applications is 15.1.2024.
Further information is available from Professor Craig Primmer, craig.primmer(at)helsinki.fi.
The University of Helsinki Organismal and Evolutionary Biology Research Programme and the research groups of Prof. Jaakko Kangasjärvi , Dr. Maija Sierla and Dr. Cezary Waszczak are seeking to hire two highly motivated Postdoctoral Researchers to study Arabidopsis thaliana guard cell signalling.
Project Descriptions
The projects aim at molecular-level understanding of guard cell signalling and stomatal function in response to environmental stimuli. We also address connections between stomatal and vascular function. We use forward- and reverse-genetics, interactomics, and phosphoproteomics approaches coupled with plant physiology, molecular and cell biology and biochemistry to identify new components in guard cell signalling networks and further characterize the components we have previously identified.
Project 1: We have recently conducted a forward genetic screen aiming at saturation of Arabidopsis thaliana guard cell signalling network. Through an ozone-sensitivity approach combined with whole-rosette gas exchange analysis we identified over 50 novel mutants impaired in stomatal closure ( Sierla et al., 2018 ; Takahashi et al., 2022 ; Waszczak et al., 2023 ). One of the successful candidates will be involved in mapping and functional characterization of the newly identified mutants. This project will be performed in close collaboration between research groups of Prof. Kangasjärvi, Dr Maija Sierla and Dr Cezary Waszczak.
Project 2: We are using interactomics (Co-IP and TurboID) and phosphoproteomics approaches, and suppressor mutant screens with known stomatal regulators to further characterize the guard cell signalling pathways regulating stomatal movements in response to both abiotic and biotic stimuli. We also investigate the coordination of stomatal and vascular function. Our main focus is on the receptor-like pseudokinase GHR1 ( Sierla et al., 2018 ; Hõrak et al., 2016 ) and its novel interactors. One of the successful candidates will lead some of these research lines based on their expertise and interest in the group of Dr Maija Sierla.
The candidates will be integrated into an international research team of experts in plant stress biology and environmental signalling and participate in extensive collaborations, including mobility exchanges within Europe.
Qualifications:
doctoral degree in molecular or cell biology, plant biology, biochemistry or other relevant field
ability to conceive, execute, and complete research projects
creativity and independent thinking
excellent written and verbal communication skills
Research Environment
The University of Helsinki, founded in 1640, is one of the world’s leading universities for multidisciplinary research. The university has an international academic community of 40,000 students and staff members. The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.
The projects are funded by the Research Council of Finland Centre of Excellence in Tree Biology that brings together ten PIs from the University of Helsinki (UH) and two from the Natural Resources Institute Finland (Luke), who together with a large network of international collaborators form a multidisciplinary team of experts in plant genetics, physiology and computational modelling. The Organismal and Evolutionary Biology Research Programme operates at the University of Helsinki Viikki Biocenter which is the largest hub for molecular plant biology in Finland. The Viikki Biocenter has exceptional research facilities, including state-of-the-art core facilities such as plant growth chambers, greenhouses, and a high-throughput plant phenotyping facility.
Employment Conditions
the earliest starting date is 1st of March 2024
fixed-term contract (6 months trial period) of 2-3 years with a possibility for extension
starting salary ca. 3300 – 3800 EUR/month depending on the qualifications and experience
occupational healthcare
How To Apply
The application should include the following attachments as a single pdf-file (in English):
a cover letter describing shortly your background and motivation to apply to this position (max. 2 pages). In the cover letter specify which position you are most interested in.
CV including a list of publications (if any) with a brief summary explaining your own contributions
Names and contact information of two referees, who are willing to provide reference letters upon request
Please submit your application using the University of Helsinki Recruitment System via the apply link. The deadline for submitting the application is 30th of January 2024. The call may close earlier if suitable candidates are found.
For more information please contact Jaakko Kangasjärvi ( jaakko.kangasjarvi@helsinki.fi ), Maija Sierla ( maija.sierla@helsinki.fi ) or Cezary Waszczak ( cezary.waszczak@helsinki.fi ). For more information on the research groups please visit our websites:
Jaakko Kangasjärvi: https://researchportal.helsinki.fi/en/organisations/plant-ros-signalling
Maija Sierla: http://www.helsinki.fi/plant-environmental-signalling
Hõrak H, Sierla M, Tõldsepp K, Wang C, Wang Y-S, Nuhkat M, Valk E, Pechter P, Merilo E, Salojärvi J, Overmyer K, Loog M, Brosché M, Schroeder J, Kangasjärvi J and Kollist H (2016) A dominant mutation in the HT1 kinase uncovers MAP kinases and GHR1 in CO2-induced stomatal closure, The Plant Cell, 10: 2493-2509
Sierla M, Hõrak H, Overmyer K, Waszczak C, Yarmolinsky D, Maierhofer T, Vainonen JP, Salojärvi J, Denessiouk K, Laanemets K, Tõldsepp K, Vahisalu T, Gauthier A, Puukko T, Paulin L, Auvinen P, Geiger D, Hedrich R, Kollist H, Kangasjärvi J (2018) The receptor-like pseudokinase GHR1 is required for stomatal closure. The Plant Cell 30: 2813–2837
Takahashi Y, Bosmans KC, Hsu PK, Paul K, Seitz C, Yeh CY, Wang YS, Yarmolinsky D, Sierla M, Vahisalu T, Waszczak C, McCammon JA, Kangasjärvi J, Zhang L, Kollist H, Trac T, Schroeder JI (2022) Stomatal CO2/bicarbonate sensor consists of two interacting protein kinases, Raf-like HT1 and non-kinase-activity activity requiring MPK12/MPK4. Sci Adv 8: eabq6161
Waszczak C, Yarmolinsky D, Leal Gavarrón M, Vahisalu T, Sierla M, Zamora O, Carter R, Puukko T, Sipari N, Lamminmäki A, Durner J, Ernst D, Winkler JB, Paulin L, Auvinen P, Fleming AJ, Andersson MX, Kollist H, Kangasjärvi J (2023) Synthesis and import of GDP-l-fucose into the Golgi affect plant–water relations. New Phytologist. doi: 10.1111/nph.19378
Dosentti Pieta Mattilan tutkimusryhmään haetaan tutkijatohtoria/erikoistutkijaa projektiin, jossa selvitetään virusantigeenien prosessointia ja esittelyä B-soluissa, tavoitteena ymmärtää paremmin tämän prosessin roolia ja siihen vaikuttavia tekijöitä rokotevasteessa. Valitun hakijan toivotaan aloittavan 1.3.2024 (tai sopimuksen mukaan). Tehtävä täytetään kaksivuotisena, mutta on mahdollista, että tehtävä jatkuu.
Ryhmämme tutkii B lymfosyyttien aktivaatiota, mikä mahdollistaa suojaavien korkean affiniteetin omaavien vasta-aineiden muodostumisen. Käytämme paljon moderneja mikroskopian ja proteomiikan työkaluja yhdistettynä soluaktivaatiokokeisiin sekä hiirimalleihin, joiden avulla pyrimme paremmin ymmärtämään B-solujen aktivaation säätelyä. Läpimenevänä tavoitteenamme on löytää uusia kohteita lääkekehittelyyn B-solulähtöisiin lymfoomiin tai immuunijärjestelmän häiriöihin, kuten immuunipuutoksiin tai autoimmuunisairauksiin, ja toisaalta löytää työkaluja tehokkaampien rokotteiden kehittelyyn.
Palkattava henkilö tulee työskentelemään osana EU-rahoitettua (Horizon Europe) projektia Yellow4FLAVI ( Deconstructing the protective immunity of yellow fever virus 17D to inform flavivirus vaccine design ). Yellow4FLAVI konsortio käsittää 13 partneria 7 eri maasta. Konsortiota koordinoi Prof. Giovanna Barba-Spaeth Institute Pasteurista, (Pariisi, Ranska). Meidän osuutemme on tutkia keltakuumeviruksen antigeenin prosessointia ja esittelyä B-soluissa. Työ sisältää erilaisten mikroskopiatekniikoiden käyttöä ja kehittelyä sekä soluaktivaatiokokeiden pystyttämistä kyseistä tarkoitusta varten tiiviissä yhteistyössä Ranskassa ja Saksassa sijaitsevien kollaboraattoreidemme kanssa. Yellow4FLAVI projektin taustaa hieman: Aiemmin suurimmaksi osaksi tropiikkiin liitetyt flavivirukset, kuten Zika, dengue, Länsi-Niilinvirus ja keltakuume ovat laajenemassa globaaliksi terveysuhaksi. Ilmastonmuutos ja kaupungistuminen ovat edesauttaneet viruksia levittävien hyttysten alueiden laajenemista ja Euroopassa onkin viime vuosina havaittu useita paikallisesti leviäviä epidemioita. Keltakuumevirus 17D (YF17D) on heikennetty viruskanta, jolla saavutetaan rokotevaste, joka on ylitse muiden tehokkuudessa ja turvallisuudessa. Rokotteen menestyksestä huolimatta emme ymmärrä, mikä tekee siitä niin erinomaisen. Yellow4FLAVI konsortio pyrkii ymmärtämään näitä mekanismeja, yhdistäen viruksen rakenteen saavutettuun immuunivasteeseen, tavoitteena oppia kehittämään parempia rokotteita myös muita flaviviruksia vastaan.
