Managerial, Professional and Specialist Staff – MPSS
Advert
Technical Specialist Division of Cancer and Genetics School of Medicine College of Biomedical and Life Sciences
We
are seeking a highly talented and enthusiastic scientist to join the
Tissue Microenvironment Group, working on an exciting new project
entitled “Making a difference in prostate cancer: developing a new blood
based test for early diagnosis of aggressive prostate cancer”. The
project is led by Dr Jason Webber (Division of Cancer & Genetics,
School of Medicine) and funded by Cancer Research Wales.
When
diagnosing patients with prostate cancer, it is difficult to
discriminate patients with slow growing tumours from those with
aggressive tumours who require urgent treatment. Currently, doctors
rely on tissue biopsy, which is an invasive procedure with potential for
numerous complications. There remains an unmet need for a simple,
non-invasive, assay for diagnosis of prostate cancer.
Utilising
existing expertise within the group, you will support the development
of a blood-based test, to detect RNAs contained within extracellular
vesicles, capable of identifying patients with aggressive prostate
cancer. This will involve collaboration with researchers locally, at the
Wales Gene Park, and further afield.
Applicants should
have a degree in a biomedical science and relevant laboratory
experience. In addition, you must have excellent organisational skills
and previous experience in the conduct, interpretation and reporting of
qualitative and quantitative research.
This
post is part-time (28 hours per week – pattern to be agreed), fixed
term until 31 January 2022 and available from 3 February 2020.
Salary
£27,511 – £31,866 per annum, pro rata for hours worked (Grade 5). It
is anticipated that the maximum starting point will be point 23 (£27,511
per annum, pro rata).
Date advert posted: Monday, 28 October 2019
Closing date: Thursday, 28 November 2019
Cardiff
University is committed to supporting and promoting equality and
diversity and to creating an inclusive working environment. We believe
this can be achieved through attracting, developing, and retaining a
diverse range of staff from many different backgrounds. We therefore
welcome applicants from all sections of the community regardless of sex,
ethnicity, disability, sexual orientation, trans identity, relationship
status, religion or belief, caring responsibilities, or age. In
supporting our employees to achieve a balance between their work and
their personal lives, we will also consider proposals for flexible
working or job share arrangements.
Job Description
Job Purpose
Support
the University in development of a novel assay for detection of
extracellular vesicles from cell culture and patient biofluids, carrying
out supporting work, providing advice, guidance and support, and
leading projects within this area.
Duties and Responsibilities
Key Duties
• Provide
professional advice and guidance on processes and procedures associated
with the isolation and characterisation of extracellular vesicles to
internal and external customers, using judgement and creativity to
suggest the most appropriate course of action where appropriate, and
ensuring complex and conceptual issues are understood • Investigation
and analysis of specific issues relating to detection of extracellular
vesicles, creating recommendation reports, supported by advances within
the field of extracellular vesicle biology • Ensure that the
provision of a proof-of-concept assay for detection of patient-derived
extracellular vesicles is delivered to the institution, proactively
changing the delivery according to customer requirements • Collaborate with others in order to make recommendations for developments of established processes and procedures • Establish
working relationships with key contacts, developing appropriate
communication links with the University’s Schools/Directorates and
outside bodies as required • Create specific working groups from
colleagues across the University to achieve Tissue Microenvironment
Group (TMEG) and wider Division of Cancer & Genetics (DCG) / School
of Medicine objectives • Supervise specific project teams on an occasional basis to accomplish key objectives • Develop and deliver training within isolation and detection of extracellular vesicles • Undertake a variety of administrative duties to support the department • Instruct
and guide other employees across the University within aspects of
extracellular vesicle biology (including isolation, detection, and
characterisation) as required
General Duties
• Ensure that an understanding of the importance of confidentiality is applied when undertaking all duties • Abide by University policies on Health and Safety and Equality and Diversity • Perform other duties occasionally which are not included above, but which will be consistent with the role
Person Specification
Essential Criteria
Qualifications and Education
1. Degree in a biomedical science/NVQ 4 or equivalent Professional membership/experience
Knowledge, Skills and Experience
2. Substantial experience of working within a research laboratory 3. Able
to demonstrate professional knowledge of research methods and
techniques (e.g. cell culture, RNA isolation, qPCR, ELISAs, flow
cytometry etc) to give advice and guidance to internal and external
customers 4. Ability to set up standard office systems and procedures and make improvements as appropriate
Customer Service, Communication and Team Working
5. Ability
to communicate conceptually detailed and complex information
effectively and professionally with a wide range of people 6. Evidence of ability to explore customers’ needs and adapt the service accordingly to ensure a quality service is delivered
Planning, Analysis and Problem Solving
7. Evidence
of ability to solve expansive problems using initiative and creativity;
identifying and proposing practical solutions and resolving problems
with a range of potential outcomes 8. Evidence of demonstrable
knowledge of key advances within research methods and techniques (e.g.
cell culture, RNA isolation, qPCR, ELISAs, flow cytometry etc) 9. Evidence
of ability to work unsupervised to deadlines, planning and setting
priorities for own work and that of others and monitoring progress
Other
10. A willingness to undertake further training and development
Desirable Criteria
11. Experience of working with/analysing data from next generation sequencing studies 12. Postgraduate/Professional qualification 13. Experience of working in a Higher Education environment 14. A demonstrable history of contributing to excellent publications in the area 15. Knowledge/experience of working with extracellular vesicles
Additional Information
IMPORTANT: Evidencing Criteria
It
is School of Medicine’s policy to use the person specification as a key
tool for short-listing. Candidates should evidence that they meet ALL
of the essential criteria as well as, where relevant, the desirable. As
part of the application process you will be asked to provide this
evidence via a supporting statement.
Please ensure when
submitting this document / attaching it to your application profile you
name it with the vacancy reference number, in this instance for this
post, 9216BR.
If candidates do not provide
written evidence of meeting all of the essential criteria then their
application will not be progressed. The School of Medicine welcome the
submission of CVs to accompany evidence of the job-based criteria.
The University of Helsinki
is a vibrant scientific community of 40,000 students and researchers.
It is one of the leading multidisciplinary research universities and
ranks among the top 100 international universities in the world. It is
currently investing heavily in life sciences research.
The Institute of Biotechnology (BI) (https://www.helsinki.fi/en/hilife-institute-of-biotechnology) is an international research unit within the Helsinki Institute of Life Science (HiLIFE) https://www.helsinki.fi/en/helsinki-institute-of-life-science
of the University of Helsinki. The research groups of BI conduct
research and develop infrastructures in biotechnology and modern
biosciences at the highest international level, actively applying the
results for the benefit of society.
The Institute of Biotechnology invites applications from outstanding candidates for the position of
A GROUP LEADER
in the areas of Molecular and Cell Biology, Developmental Biology,
Genomics and Quantitative Biology, Structural Biology, or Plant Biology.
The position is initially for five years with a possibility for a
4-year extension at BI based on external evaluation and eventual tenure
at a relevant faculty of the University of Helsinki following
commendable evaluation. Early career stage researchers are especially
encouraged to apply.
The successful candidate has a solid track record including a PhD or
equivalent degree, post-doctoral experience in an international setting,
and recent demonstration of excellence in research. The candidate is
expected to develop an independent externally funded line of research.
We offer an international, inspiring, and supportive research
environment, along with excellent research facilities including in-house
state-of-the art technologies in imaging, genomics, proteomics, CryoEM,
crystallography, and NMR. The successful candidate will also enjoy
access to all HiLIFE infrastructure platforms (https://www.helsinki.fi/en/helsinki-institute-of-life-science/hilife-res…).
The salary is based on the salary system of the Finnish universities
for teaching and research personnel, depending on the appointees’
qualifications, career stage and experience. The position also comes
with an attractive negotiable 3-5 year startup package.
The University of Helsinki offers comprehensive services to its
employees, including occupational health care, health insurance, sports
facilities, and opportunities for professional development. Finland is a
member of the EU, has high quality free schooling (also in English),
generous family benefits, and excellent healthcare. Finland was recently
ranked as the best country in the world for expat families and Helsinki
in the world’s top ten most livable cities. For more information about
working at the University of Helsinki and living in Finland, please see https://www.helsinki.fi/en/university/working-at-the-university.
The application consists of an online form and a single pdf
attachment. On the form, the applicant includes personal information,
contact information for three referees, a list of five selected
publications describing the key findings, the applicant’s contribution
and the number of citations for each of them according to Google
Scholar. The attached pdf should include a cover letter describing the
motivation to apply for this position (max 1 page), a curriculum vitae
(max 2 pages), a full list of publications, a statement of scientific
achievements (1 page) and a summary of research plans (2 pages).
Evaluation of applications will be carried out by an Appointment
Committee. Short-listed candidates must successfully complete an
interview process including a research seminar and evaluation by BI’s
Scientific Advisory Board. The interviews are expected to take place on
January 9-10th, 2020, and the recruitment to be completed by the end of
March 2020.
To apply, please submit your application using the University of
Helsinki electronic recruitment system by clicking on ”Apply for the
position”. Current employees of the University of Helsinki must submit
their applications through the SAP HR portal.
The closing date for submitting applications is November 10th, 2019.
For further information, please visit our website (https://www.helsinki.fi/en/hilife-institute-of-biotechnology)
or contact one of the following for informal inquiries: BI Director
Olli Silvennoinen (olli.j.silvennoinen(at)helsinki.fi) or Deputy
Director Marja Mikkola (marja.mikkola(at)helsinki.fi). Further
information on the recruitment process may be obtained from HR
Specialist Anu Roine, anu.roine(at)helsinki.fi. For technical support
with the online recruitment system, please, contact recruitment@helsinki.fi.
McWilliams Laboratory STEMM Program, Research Programmes Unit RPU, Faculty of Medicine, University of Helsinki
Who we are:
The McWilliams Laboratory is driven to understand the molecular
regulation of autophagy in tissues, with a vision to develop novel
therapeutic strategies for a diverse range of disease states. We have a
particular focus on neurodegeneration and metabolic diseases. We are a
young and dynamic laboratory with substantial external funding acquired
to realise this mission.
To ensure we have the chance of making the most significant impact,
we partner with other world-class laboratories in both academia and the
private sector. Our new laboratory is embedded within the Stem Cells and
Metabolism Research Program (STEMM), at the RPU – Biomedicum Helsinki.
This multifaceted role will feature exposure to state-of-the-art
techniques in neuroscience, cell biology and molecular medicine.
What we need:
Our continued success depends on our highly engaged and talented
research professionals. To this effect, we have a strong ’team science’
ethos within an organised, structured and well-resourced research
environment. We now seek an experienced ’Laboratory Manager and Research
Specialist’ to join our growing team. The successful candidate will be
highly organised and experienced in a broad range of techniques in
biomedical science. Ideally, they will have experience as a technician
or laboratory coordinator in a similar or related environment. This post
is an intellectually stimulating, rewarding and multifaceted position.
The candidate should relish the opportunity to take a leading role in
managing the operations of a new laboratory, and excited to contribute
their research expertise on cutting edge questions in disease biology.
Key Responsibilities:
The candidate will integrate into an experienced and organised team and will perform tasks including:
– Assisting/performing experiments and essential lab procedures
– Providing insights and solutions into technical matters
– Monitoring of mouse colonies, record keeping
– Ordering and maintaining laboratory items (equipment, reagent stocks, invoices)
· Keeping and organising records (Chemical inventory, equipment, antibodies, cell stocks)
– Ensuring a high standard of laboratory training and safety
Desirable Skills:
Although training is provided for all aspects of this position, the ideal candidate will have
experience in one or more of the following techniques:
– Histology (tissue processing, cryosectioning, immunohistochemistry)
– Molecular biology: DNA/RNA extraction, PCR, genotyping, primer design and cloning and plasmid preps.
Experience with mitochondrial biology or metabolism is considered an advantage
– Experience with animal models (experiments, colony maintenance, breeding, sample processing)
– Experience with cell culture/cell biology
-Working with viruses
-iPSC and neuron culture is considered a significant advantage
Essential Attributes:
– You have a Laboratory technician education and equivalent experience
OR you hold an MSc in an appropriate biomedical discipline with relevant
research experience
– You are highly organised, enjoys standardisation of experimental techniques
– You are committed to reproducibility with a detail-orientated mindset
– You are enthusiastic about working in a dynamic, fast-paced and international environment
– You have a good command of both English and Finnish (written and spoken)
– You are a collegial and team-oriented individual, capable of working independently with an adaptable and resourceful attitude.
– You have relevant IT proficiency (e.g. routine use of MS Office –
Word, Excel, Powerpoint; Online Databases, other software associated
with laboratory devices)
Salary and contract:
This exciting role will be a full-time position for two years starting
1st November 2019 (or upon mutual agreement). The salary will be
commensurate with qualifications and experience based on the University
salary system. As a research professional in the McWilliams Lab, the
candidate will receive the same opportunities for mentoring and career
development available to students and postdocs.
How to Apply:
The application should be written in English and submitted as a single PDF containing the following documents:
– A brief personal statement describing yourself and your experience (one-page maximum)
– An up-to-date CV including contact details for two referees (no more than two pages).
Please apply, together with the attachment of a single pdf file,
through the University of Helsinki electronic recruitment system by
clicking on ”Apply for job”. Internal applicants (i.e., current
employees of the University of Helsinki) must submit their applications
through the SAP HR portal no later than 13 November 2019.
Enquiries can be directed to:
Assistant Prof. Thomas McWilliams (tel. during office hours 0451160722; thomas.mcwilliams(at)helsinki.fi)
The Faculty of Medicine promotes scientific research of a high
standard and is responsible for providing research-based undergraduate
and postgraduate education in medicine, dentistry, psychology and
logopedics, as well as for the English-language Master’s Programme in
Translational Medicine. In addition to its teaching and research
activities, the Faculty serves as a significant expert organisation in
the healthcare sector and contributes to the discourse on ethics in the
field. In terms of research, the Faculty aims for a place among the best
medical faculties in the world, while consolidating and strengthening
its status as a top-level institution of medical education.
Together with the HUS Helsinki University Hospital and the Helsinki
Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University
of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH).
This medical center has been very successful in international
comparisons, ranking among the top 10 medical campuses in Europe and
among the top 50 globally.
The Kuopio Center for Gene
and Cell Therapy (KCT) is a research institute focused on developing
novel gene and cell therapy products in the class known as advanced
therapy medicinal products (ATMPs). KCT’s niche is in the interface
between academic research and the commercial biotechnology industry. In
addition to Cell Therapy expertise KCT has extensive experience dealing
with the design, development and manufacturing of AAV, adenovirus and
lentivirus vectors.
The Gene Therapy
Unit at KCT invites applications for a Research Scientist position. We
are seeking a creative investigator, who is able to both plan and take
forward selected research projects. The projects may involve, but are
not limited to adenovirus vector’s virus-host interactions, vector
manufacturing development, lentivirus vector modifications, producer
cell line modifications and analytical assay development.
Successful candidates will have a degree (MSc/PhD) in biosciences, virology, microbiology, biochemistry, molecular biology, cell biology
or related fields. Expertise in cell culture, transfections, virus
production, transductions, virus titering assays, analytical assay
qualification/validation, assay statistics, ELISAs, ddPCR, electron
microscopy, automated image analysis or flow cytometry can be highly
beneficial.
We hope that your way
of working is systematic and precise. As a person, we would like you to
be open-minded towards new challenges and spread good team spirit. You
also need to communicate fluently both in written and spoken English and
have good computer skills.
The
position is 2-year fixed term. We offer you active and lively work
community with highly skilled and experienced personnel in translational
research.
Orion Corporation is a globally operating Finnish pharmaceutical
company – a builder of well-being. Orion develops, manufactures and
markets human and veterinary pharmaceuticals and active pharmaceutical
ingredients.
Description of position
In the CNS Therapy Area, we are building up our portfolio and are
looking for enthusiastic and innovative scientists who can contribute
with strong disease biology knowledge in the field of neurodegenerative
disorders (NDD) or chronic pain in our Disease Biology team in Turku,
Finland.
Your main responsibilities will be to:
Establish, characterize and implement state-of-the-art animal models
to unravel mechanisms in neurodegenerative diseases (ALS, PD) and pain
such as Transgenic (Tg), Knock Out (KO), Knock In (KI)
Build-up target validation from in-vitro to in-vivo and bring in new technologies and protocols
Use translational models, translate from bed-to-bench and back
Generate and evaluate new project ideas with other pain/ neurodegenerative diseases (NDD) scientists
Actively contribute to project ideation, planning and execution of research activities in the fields of NDD and/or pain.
Analyse and interpret data and effectively conclude, document and communicate results.
Interface with external academic, biotechnology, and contract research organizations.
Collaborate with other CNS scientists & groups & global functions within the company
Description of unit
Therapy area of the Central Nervous System (CNS) is accountable for
the research and development of medications for NDD and pain at Orion.
Our team builds the R&D CNS portfolio and CNS strategy in close
collaboration with business and all R&D global functions. We are
focusing on Parkinson’s disease (PD), Amyotrophic lateral sclerosis
(ALS) and chronic pain. Currently, we are about 20 people working for
the CNS portfolio, including a laboratory team for the Disease Biology
ensuring that we get data from well-planned and conducted experiments to
verify target confidence and to ensure the way forward for the new
ideas and research projects. This position belongs to the Disease
Biology team in Turku, Finland, which we plan to grow to meet our future
needs.
We offer
We offer exciting opportunities to create and have an impact to the future therapies for patients.
In Orion we have a highly interesting R&D pipeline and
enthusiastic working environment with opportunities to use your own
strengths to build your competence development and career. As an expert
of your own field you will be a member of multi-disciplinary team
jointly innovating and developing new treatments for the patients.
Appreciation of colleagues and continuous development are part of our
core values. The culture of Orion R&D is informal and we enjoy
working together.
We are passionate about the patient welfare and serve as The Voice of
Science and the Patient – if this inspires you too – join us!
We wish you have
PhD in either NDD or pain related fields (0+ year(s) experience; Title will depend on experience)
Industry experience is an advantage
Understanding of ALS, PD and/or pain related disease mechansims and experience in animal model set up (Tg, KO, KI)
Technical skills in gene-editing technologies such as Crispr-CAS, shRNA; surgical techniques such as stereotaxic surgery
Experience, understanding and interest on translational models, how to translate from bed-to-bench and back
Good organizational and people skills and working in a team environment
Passion to work hands-on in the laboratory
Excellent communication skills in English
Additional information
Would you like to know more about the position? Please contact Malik
John Mohammed, Research Director NDD +358509667871. He is best available
during the following times (EEST): Friday 25th of Oct 9.00 –
11.00, Thursday 31st of Oct 15.00 – 16.00 and Friday 8th of Nov 15.00 –
16.00.
Orion Corporation operates in more than 25 countries, where we
Orionees, 3400 in total, work in all kinds of positions. We encourage
people to develop their competences, and offer opportunities to affect
own job description and create own career path at Orion.
#LI-ORION
Approved medical examination
which also includes drug testing is required prior to the employment. We
will also carry out a security clearance prior to the employment for
the selected person.
Orion Corporation is a globally operating Finnish pharmaceutical
company – a builder of well-being. Orion develops, manufactures and
markets human and veterinary pharmaceuticals and active pharmaceutical
ingredients.
Description of position
In the CNS Therapy Area, we are building up our portfolio and are
looking for enthusiastic and innovative scientists who can contribute in
the field of neurodegenerative disorders (NDD) or chronic pain in our
laboratory in Turku, Finland.
Your main responsibilities will be to:
Establish, characterize and implement state-of-the-art cellular
models to unravel disease mechanisms in neurodegenerative diseases (PD
& ALS) and pain
Setup new in-vitro technologies and protocols
Build-up in-vitro target validation and help translate to in-vivo assays
Generate and evaluate new project ideas with other pain/ neurodegenerative diseases (NDD) scientists
Actively contribute to project ideation, planning and execution of research activities in the fields of NDD and/or pain
Analyse and interpret data and effectively conclude, document and communicate results
Interface with external academic, biotechnology, and contract research organizations
Collaborate with other CNS scientists & groups & global functions within the company
Description of unit
Therapy area of the Central Nervous System (CNS) is accountable for
the research and development of medications for NDD and pain at Orion.
Our team builds the R&D CNS portfolio and CNS strategy in close
collaboration with business and all R&D global functions. We are
focusing on Parkinson’s disease (PD), Amyotrophic lateral sclerosis
(ALS) and chronic pain. Currently, we are about 20 people working for
the CNS portfolio, including a laboratory team for the Disease Biology
ensuring that we get data from well-planned and conducted experiments to
verify target confidence and to ensure the way forward for the new
ideas and research projects. This position belongs to the Disease
Biology team in Turku, Finland, which we is growing to meet our future
needs.
We offer
We offer exciting opportunities to create and have an impact to the future therapies for patients.
In Orion we have a highly interesting R&D pipeline and
enthusiastic working environment with opportunities to use your own
strengths to build your competence development and career. As an expert
of your own field you will be a member of multi-disciplinary team
jointly innovating and developing new treatments for the patients.
Appreciation of colleagues and continuous development are part of our
core values. The culture of Orion R&D is informal and we enjoy
working together.
We are passionate about the patient welfare and serve as The Voice of
Science and the Patient – if this inspires you too – join us!
We wish you have:
PhD in Neuroscience, cell biology or other related field (0+ year(s) experience; Title will depend on experience)
Industry experience is an advantage
Strong expertise in cell culture, including primary neurons and iPSC
Technical skills in biochemical, molecular and cell biology
techniques, gene editing and viral vector technologies, and microscopy
and imaging are desirable
Good networking and communication skills and willingness to
collaborate with Internal & External partners (academic and
industrial)
Good organizational and people skills and working in a team environment
Passion to work in the laboratory
Fluent written and spoken English
Additional information
Would you like to know more about the position? Please contact Malik
John Mohammed, Research Director NDD +358509667871. He is best available
during the following times (EEST): Friday 25th of Oct 9.00 –
11.00, Thursday 31st of Oct 15.00 – 16.00 and Friday 8th of Nov 15.00 –
16.00.
Orion Corporation operates in more than 25 countries, where we
Orionees, 3400 in total, work in all kinds of positions. We encourage
people to develop their competences, and offer opportunities to affect
own job description and create own career path at Orion.
#LI-ORION
Approved medical examination
which also includes drug testing is required prior to the employment. We
will also carry out a security clearance prior to the employment for
the selected person.
Orion Corporation is a globally operating Finnish pharmaceutical
company – a builder of well-being. Orion develops, manufactures and
markets human and veterinary pharmaceuticals and active pharmaceutical
ingredients.
Job description
We are looking for a professional with a strong background in
delivery technologies especially for large molecules for CNS and
oncology targets to establish technology platform for these technologies
in Turku, Finland. In order to drive successfully our internal drug
discovery programs your primary responsibilities will include designing,
planning, executing and troubleshooting of lipid based delivery
vehicles including physico-chemical characterization, stability studies,
PK and PD studies. Together with Biologics function other option like
bispecific antibodies fusion proteins and aptamers are on the scope as
well. You contribute actively to development of analytical methods for
thorough characterization of delivery vehicles. Much of the progress is
done in the laboratory and you will therefore have a good possibility to
do a lot of hands-on laboratory work. As a senior scientist, evaluation
and supporting discovery collaborations and CRO activities on you
competence area is a part of your job description.
Description of the unit
Orion’s pharmaceutical innovations are created within its R&D
organization, including e.g. non-clinical research, clinical
development, formulation development and medical affairs. The
organization employs top professionals in the field of drug molecule
development and optimization.
The newly established Biologics and New Modalities team is part of
our R&D organization and it is responsible for bringing as new
treatment modalities for Orion’s pipeline covering therapeutic
nucleotides, delivery technologies and gene therapy. Adding the
possibility to modulate the target with either small or large molecules
enables us to choose the right target and then use the best modalities
to modulate the target protein in order to create the best value for
patients. To fulfill this exciting task the New Modalities function is
strengthened by recruiting new R&D experts with a track record of on
advanced therapy modalities. The function is currently to set up and
you have a great opportunity to be part of developing our processes.
We offer
We offer exciting opportunities to create and have an impact to the future therapies for patients.
In Orion we have a highly interesting R&D pipeline and
enthusiastic working environment with opportunities to use your own
strengths to build your competence development and career. As an expert
of your own field you will be a member of multi-disciplinary team
jointly innovating and developing new treatments for the patients.
Appreciation of colleagues and continuous development are part of our
core values. The culture of Orion R&D is informal and we enjoy
working together.
We are passionate about the patient welfare and serve as The Voice of
Science and the Patient – if this inspires you too – join us!
Requirements
To succeed in this senior scientist role you should have a PhD in
biology, pharmacy or biophysics with a track record of developing drug
delivery vehicles and thorough hands-on experience of laboratory work
and several years of working experience from pharma industry in
developing novel solutions for large drug molecule delivery for CNS
indications. You have thorough working knowledge and understanding of
nanoparticle or liposomal delivery formulations.
Since you have a central role in implementing these new delivery
technologies to our portfolio patience and willingness to create new
things is a must. The role includes collaboration within Orion and with
various collaborators therefore strong communication skills and an
ability to convince your audience is an asset.
Contact information
Would you like to know more about the position? Please contact Jyrki
Lehtimäki, Senior Manager Strategic Development, +358509667478. He is
best available during the following times (Finnish times): 1st November
at 14-15 pm and 6th November at 9-10 am or 15-16 pm. Please send us your
application by November 17th.
Orion Corporation operates in more than 25 countries, where we
Orionees, 3200 in total, work in all kinds of positions. We encourage
people to develop their competences, and offer opportunities to affect
own job description and create own career path at Orion.
Orion Corporation is a globally operating Finnish pharmaceutical company
– a builder of well-being. Orion develops, manufactures and markets
human and veterinary pharmaceuticals and active pharmaceutical
ingredients.
Description of position
In this Research
assistant role your days will include hands-on laboratory work such as
pharmacological testing, biophysical characterization and preparation of
therapeutic antibodies and nucleotides (incl. binding and functional
studies), cell culture, assay set-ups and validations. You will
schedule, execute and report the experiments. You will also provide
assistance to the team when larger studies are conducted.
Description of the unit
Orion’s pharmaceutical innovations are created within its R&D
organization, including e.g. non-clinical research, clinical
development, formulation development and medical affairs. The
organization employs top professionals in the field of drug molecule
development and optimization.
The recently established
Biologics and New Modalities teams are part of our R&D organization
and they are responsible for bringing forward our increasing or
biologics and new modalities pipeline in the therapy areas Oncology, CNS
and Rare diseases. Adding the possibility to modulate the target with
either small or large molecules enables us to choose the right target
and then use the best modalities to affect the target protein in order
to create the best value for patients. To fulfill this exciting task
these teams are now recruiting additional R&D experts with a track
record of developing biopharmaceuticals. These teams have recently been
established and you have a great opportunity to be part of developing
our processes.
We offer
We offer exciting opportunities to create and have an impact to the future therapies for patients.
In Orion we have a highly interesting R&D pipeline and enthusiastic
working environment with opportunities to use your own strengths to
build your competence development and career. As an expert of your own
field you will be a member of multi-disciplinary team jointly innovating
and developing new treatments for the patients. Appreciation of
colleagues and continuous development are part of our core values. The
culture of Orion R&D is informal and we enjoy working together.
We are passionate about the patient welfare and serve as The Voice of
Science and the Patient – if this inspires you too – join us!
Requirements
To be successful in this role we hope you have hands-on experience of
laboratory work related to antibody or nucleotide engineering and
background of cell biology, immunology or biochemistry. Laboratory
working experience in pharma industry is an advantage and experience in
laboratory work using viral vectors is also considered beneficial.
Additionally we expect that you have a BSc degree in a related field
(for example biotechnology engineering or health sciences).
In
our team, it is important that you are not afraid to take
responsibilities and you enjoy helping others. You are accurate and
persistent in your work. Good communication skills in English are needed
and you work well with others. We hope you are excited of getting new
tasks and developing yourself.
Contact information
Would you like to know more about the position? Please contact Tim
Holmström, Head of Biologics, +358509667314. He is best available during
the following times (EEST): Monday 4th of November between 9-10 AM, and
Wednesday 13th of November between 9-10 AM.
Orion Corporation
operates in more than 25 countries, where we Orionees, 3200 in total,
work in all kinds of positions. We encourage people to develop their
competences, and offer opportunities to affect own job description and
create own career path at Orion.
#LI-ORION
WWW-osoite http://www.orion.fi Yhteystiedot
Would you like to know more about the position? Please contact Tim
Holmström, Head of Biologics, +358509667314. He is best available during
the following times (EEST): Monday 4th of November between 9-10 AM, and
Wednesday 13th of November between 9-10 AM. Työpaikan osoite 20380 TURKU Työ alkaa Mahdollisimman pian Työaika kokoaikatyö Työn kesto yli 12 kuukautta Haku päättyy 17.11.2019 Ilmoitus jätetty 29.10.2019 Ilmoitusnumero 10149266
Our international multidisciplinary research group (https://bioscience.fi/research/molecular-systems-immunology/profile/ ) led by Academy Professor Riitta Lahesmaa is based at Turku Centre for Biotechnology (the Centre), BioCity Turku, Turku, Finland. We are seeking for a motivated a postdoctoral researcher or a project researcher with possibility to continue work as a doctoral candidate.
Disorders in immune system and lymphocyte function lead to inflammatory diseases e.g. rheumatoid arthritis and Type 1 Diabetes. Project will focus on studying the molecular mechanisms underlying immune mediated diseases aiming at enabling individualized treatment in the future.
Description of our organization Molecular Systems Immunology group aims at understanding the regulation of human immune system to predict, prevent and treat immune mediated disorders. We study epigenetic and transcriptional regulation of T cells and molecular mechanisms of immune mediated diseases such as Type 1 Diabetes.
Turku Bioscience Centre is a joint research institute of University of Turku and Åbo Akademi University. The mission of the Centre is to promote high quality research and training. The Centre has excellent state-of-the-art technology platforms and expertise in single-cell omics, NGS, epigenomics, proteomics, computational biology and high-end cell imaging.
Qualifications
Successful candidates have:
A relevant doctor’s degree (senior/postdoctoral researcher) or a relevant master’s degree (project researcher) e.g. in life sciences or in biomedicine
High level of motivation, self-initiative and independency
Excellent team work and communication skills in English (both oral and written)
First-rate molecular and cell biology knowledge and skills with a strong background in epigenetics.
Strong publication record in international journals (postdoctoral researcher) at least in one of the following areas: immunology, molecular and cellular biology, autoimmunity, genetics, epigenetics.
Application The salary is determined by the collective agreement system of Finnish universities. These positions belong to our research personnel and the salary for a postdoctoral researcher will be 2600 – 3600 eur/month in average (or 3100 – 4200 eur/month depending on experience) and for a project researcher 2150 – 2600 eur/month in average.The position starts at earliest on Jan 1st, 2019 (or as agreed). The positions are initially for two years, one optional year possible. There is a trial period of six months.
Please include a CV, full publication list, list of selected publications and contact information for three references in your application. In addition postdoctoral researcher applicants should also enclose academic portfolio (https://www.utu.fi/en/university/come-work-with-us/academic-portfolio)
For further information on please contact: Prof. Riitta Lahesmaa, e-mail: riitta.lahesmaa (at)utu.fi .
Enquiries on the application procedure may be directed to HR Specialist Paula Luoma paula.luoma(at)utu.fi
Marie Skłodowska-Curie Actions (MSCA) Innovative Training Network (ITN)
CANCERPREV
Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation
Overview
Incidence and prevalence of many cancer types are substantially increasing worldwide[1] for three main reasons:
increased life span and aging populations,
improved methods of early detection, and
increased survival of cancer patients.
Changes in known and unknown environmental factors modify the
age-specific incidences of cancers. However, more sophisticated and
expensive treatments cannot be afforded by all societies, increasing the
urgency of boosting efforts in cancer prevention. This can be realized in three ways:
primary cancer prevention, aimed at reducing
overall cancer incidence at the population level, assessing the impact
of life style, occupational/environmental hazards, and genetic risk
factors in parallel with large-scale screening and vaccination efforts;
secondary cancer prevention,
aimed at early detection of premalignant and confined malignant
lesions, and identification of high risk lesions for removal and/or
suppression;
tertiary cancer prevention, aimed at preventing cancer recurrence in patients after treatment of a primary cancer.
This Innovative Training Network aims to establish an interdisciplinary PhD program in cancer prevention focused on two key determinants of cancer risk:
sex hormone signaling and
chronic inflammation.
Both can be significantly affected by exogenous factors such as
endocrine disruptors, cigarette smoke, and sunlight, as well as
intrinsic changes occurring with aging. Genetic influences on cancer
risk, as they relate specifically to endocrine and inflammation
signaling pathways, will be considered by analysis of a unique resource
of identical and dizygotic twin cohorts. In addition, novel
chemoprevention approaches will be assessed using chemically-developed
hormone and inflammation inhibitors. Finally, mechanistic studies will
exploit innovative preclinical mouse models developed by the
participating labs.
Through early stage researcher (ESR) co-supervision, interactive meetings and workshops, we will develop an effective cancer prevention strategy of major societal impact together with non-academic partners for: (i) novel biomarker identification and drug development; (ii) science communication efforts and public outreach.
ITN Participating Laboratories and Research Projects
This training network is based on the unifying guiding
hypothesis that sex hormone action (Work Package 1) and chronic
inflammation (Work Package 2) are important determinants of increased
cancer risk in aging populations, and that insights in these fields can
be used for novel translational applications (Work Package 3). As illustrated in the figure, we
will focus on breast and skin cancer as benchmarks of major clinical
significance, in organs with reproductive and non-reproductive
functions, respectively. The enrolled PhD students (ESRs) will address
the links between sex hormone signaling, persistent chronic
inflammation, and genetic and behavioral/environmental cancer risk
factors. They will devote most of their time and efforts to develop an
in depth research project in one of the main participating laboratories
under the direct supervion of one of the Principla Investigators (PIs).
However, they are expected to further develop and carry out some of
their research work in one or more of the other participating
laboratories, under the joint supervision of other PIs. On top of
rigorous research training, an essential objective of the program is for
students to develop scientific communication and outreach skills, which
may lead to new career opportunities in academia or the private
sector.
Summary of CANCERPREV research topics and interactions. CANCERPREV
studies breast and skin cancer as benchmarks of cancer development in
organs with reproductive or non-reproductive functions (B). The unifying
hypothesis is that deregulation of sex hormone signaling (WP1) and
inflammation (WP2) play key roles in susceptibility and premalignant to
malignant conversion of both tumor types, and that insights can be
exploited clinically (WP3).
Participating laboratories and available research projects
The CancerPrev selection committee, composed of the participating
PIs, will review and rank all applications and candidates passing the
first round of selection will be invited for an oral interview, either
by Skype or in person. At that time, they will be asked by the
interviewers to prepare a short written document on a paper / topic of
relevance to their projected future work.
Starting dates are flexible, earliest date is March 1st 2019.
