Regulatory Affairs Specialist / Assistant Vantaa, Finland
Our
in vitro diagnostic medical devices are regulated products which need
marketing authorization before sales can commence. We are looking for a Regulatory Affairs Specialist /Assistant to
coordinate product registrations in co-operation with our commercial
organization and distributors. The selected candidate will work as an
integral part of a multidisciplinary Quality Assurance and Regulatory
Affairs team to coordinate and compile product registration packages to
e.g. India and other Asia-Pacific countries. This is a fixed-term
position for approximately 3-4 months.
What can we offer
Opportunity
to gain experience in regulatory affairs and know-how in international
regulations that is a core competence in medical device industry
Work in a multi-disciplinary and international setting both with Thermo Fisher Scientific colleagues and our customers
Possibility
to work with our diverse in-vitro medical device product portfolio
including clinical chemistry products and analyzers as well as
laboratory automation solutions
How you’ll get there
M.Sc
or B.Sc degree in microbiology, biology, analytical chemistry,
biochemistry, engineering or related field, or a Student of the
mentioned scientific disciplines
Motivation to learn and interpret different regulations related to in vitro diagnostic medical device industry
Excellent verbal and written communication skills in English
Sound organizational skills and attention to detail in documenting
Self-driven attitude with persistence to take projects to the completion
Please send in your application, including a cover letter and CV. Please apply via https://jobs.thermofisher.com/
by 12.5.2019. Reference: 93305BR. Please apply as soon as possible, the
position will be filled as soon as suitable candidate is found.
Kuopio Center for Gene and
Cell Therapy (KCT) is a world-renowned research institute located in
Kuopio, Finland. Our mission is to conduct high-level research on basic
and translational fields of gene- and cell therapy. The center’s niche
is in the interface between academic research and the commercial
biotechnology industry. KCT provides an exciting environment for applied
research, discovering, establishing and developing them through Phase I
clinical trials and utilizing some of the most advanced analytical and
mechanistic proof-of-principle approaches in the sector.
We
are seeking for two enthusiastic, highly motivated and skilled
candidates with a background in disease or tumor biology, immunology and
biomarker research for Senior Scientist (post-doctoral) role in
Immunotherapy Program in Kuopio Center for Gene and Cell Therapy.
Successful candidates will have an opportunity to work in one or more of
the areas as project manager: T cell and NK cell biology, tumor
microenvironment and/or discovery of novel tumor targets. The candidate
will contribute to the projects experimentally and scientifically,
provide his/her expertise, take-leading role in internal reporting and
continue in a laboratory-focused role. The candidate will have a proven
track record of scientific productivity and ability to participate in
multidisciplinary and innovative research. The individual will
participate in strategic discussions, national and international
collaborations and coordinate project activities.
The
selected candidates will be focused in work leading to the development
of novel immunotherapies. The responsibilities include:
Effectively collaborate within the research center and national/international collaborators.
Lead the design and implementation experimentation.
Supervise young scientists and technicians working in the project.
Generate,
analyze and interpret data. Demonstrate a high level of initiative in
troubleshooting experiments and accurate data analysis. Objectively
interpret data and provide conclusions regarding project results and
direction.
Actively report research results and novelties in the field.
Qualifications:
PhD in immunology, molecular/cell biology, cancer biology,
pharmaceutical sciences or biomarker discovery OR MSc with at least 10
years of relevant experience. Knowledge on high-throughput
experimentation and large data analysis is positively evaluated. Strong
hands-on technical skills (e.g. primary cell isolation and culture, flow
cytometry, live cell imaging) and reporting in research. Ability to
multitask, manage and develop complex projects. Effective written and
spoken English language skills. Excellent interpersonal and teamwork
skills.
We offer an inspiring
multicultural environment, constructed of our enthusiastic, highly
skilled and experienced personnel in gene and cell therapy. Kuopio
Center for Gene and Cell Therapy has established working links with the
gene and cell therapy manufacturer FinVector, the A.I. Virtanen
Institute for Molecular Sciences, the University of Eastern Finland, the
National Laboratory Animal Center, and Kuopio University Hospital.
These are situated on the same Kuopio health science focused campus, the
capability of which to undertake gene and cell therapy research is made
complete by the presence of the office of the Finnish Medicines Agency
(Fimea). Finland has been ranked as the happiest country in the world
and vibrant Kuopio, is rated as Finland’s best city to live in. It
offers a safe living environment, friendly atmosphere and clean nature.
More
information Cell Therapy Unit Director Tuija Kekarainen (tel.
+358405376603 or tuija.kekarainen@kct.fi) and HR Director Johanna
Pirinen (Johanna.pirinen@kct.fi).
Please send your application before 20th May 2019.
The
Department of Anesthesiology at Washington University School of Medicine
welcomes applications for a tenure-track faculty position in The Center for Clinical Pharmacology,
a multi-institutional
research center established in partnership with with St Louis College of
Pharmacy in 2015. Successful candidates will join an existing group of
faculty with research interests in basic and translational
pharmacological science.
The goal of the Center for Clinical Pharmacology
is to focus on human-oriented research that spans the continuum of
basic to translational and clinical research, specifically through
research
that improves the use of both current and new therapeutics and
diagnostics. The Center faculty brings vast experience in
multiple aspects of drug discovery including drug mechanisms, medicinal
chemistry, PK/PD, pharmacogenomics and drug development.
The Center has a deep interest in “chemical biology”, pharmacology,
behavior and neuroscience.
This position
is targeted at established investigators at the Associate Professor or
Professor levels. Strong preference will be given to candidates
currently conducting translational and/or clinical
research. Additional leadership opportunities are available dependent
upon experience. Successful candidates will be expected to direct an
active extramurally funded research program and participate in graduate
and/or postdoctoral education, with faculty appointments
at both Washington University School of Medicine and the St Louis
College of Pharmacy. Teaching opportunities are readily available but
requirements are minimal, permitting a strong focus on research.
Generous startup funds and newly constructed lab space are
available.
Candidates
must have a doctoral degree (PharmD, PhD, MD or equivalent) and a
demonstrated record of accomplishment as an independent investigator.
Applications will be reviewed as received until the
position is filled.
To apply, send a curriculum vitae, a summary of past research activities, future research plans, and the names of three references to:
The
Department of Anesthesiology at Washington University School of Medicine
in St Louis fosters an academic culture in which clinical care,
research, and education are seamlessly integrated. The
department makes major contributions to the science of anesthesiology
through its basic science and clinical science programs, which are
heavily focused on innovative education and comprehensive, personalized
clinical training.
Founded in
1864, St. Louis College of Pharmacy is the third-oldest and
10th-largest college of pharmacy in America. The College provides
students unparalleled opportunities to learn through research,
internships, and other hands-on learning experiences with their
neighbors Barnes-Jewish Hospital, Washington University School of
Medicine, and St. Louis Children’s Hospital.
Harvard Medical School and Cancer Center at Beth Israel Deaconess Medical Center
Postdoctoral position(s) available on summer/autumn 2019
Our
lab studies how cancer cells develop drug resistance, and more
specifically, how tumor microenvironment provides support and protection
for tumor cells. Our aim is to develop better
treatment strategies to overcome this tumor microenvironment mediated
drug resistance.
To
investigate these topics we utilize both normal and cancer cells in 3D
organoid culture systems, which mimic the architecture and organization
of tissues. We use this platform in co-culture
systems to understand how stromal and epithelial cells communicate with
each other, and have also adopted the use of organoids for larger scale
methodologies, such as proteomics, metabolomics, RNA-seq and ribosome
foot-printing experiments to gain insight
into multiple mechanisms by which cancer cells become drug resistant in
3D environments.
Our
group is located in the Longwood medical area, at the Beth Israel
Deaconess Medical Center, with several established collaborations with
groups in the Harvard Medical School, MIT,
Yale, Weill Cornell and MD Anderson. This environment provides unique
opportunities for performing cutting-edge science, training in
state-of-the-art technologies, forming new collaborations, and
developing new technologies.
We
are looking for highly motivated individual(s) who have recently
finished (or about to finish) their PhD, with excellent communication
and critical thinking skills, and who are able
to work as part of a team. Training in cell biology, molecular biology
and microscopy, and basic understanding of cell signaling networks is
required.
Or
refer to the relevant publications: Muranen et al. Cancer Cell 2012,
Muranen at al. Cancer Research 2016, Muranen et al. Nature
Communications 2017 (http://rdcu.be/oqQ6).
Please
send a cover letter with short description of your research interests
and previous experience, current CV, and names of three references to
tmuranen@bidmc.harvard.edu.
The
research group of associate professor Dario Greco at the Faculty of
Medicine and Health Tehcnology and BioMediTech Institute at the Tampere
University
(Finland) focuses in advancing the fields of systems toxicology and
predictive pharmacology using big data modelling and machine learning
algorithms. We have a unique combination of expertise that spans systems
biology, toxicology, cheminformatics and bioinformatics.
Our vision is to push the state-of-the-art in predictive toxicology and
pharmacology and subsequently address some of the major challenges
arising in chemical safety assessment and drug development. We are
seeking for highly motivated postdoctoral researcher
and PhD student with a strong background in data mining, data
modelling, biostatistics and machine learning.
The
main tasks will include: integrating, analyzing and modelling large and
diverse datasets comprising molecular descriptors and mechanism of
action
(OMICS data) of chemicals and nanomaterials; analyzing and modelling
large OMICs data sets of molecular epidemiology; collaborating with
other researchers in Finland and abroad.
The
ideal candidates hold a M.Sc./Ph.D. in relevant disciplines with a
strong publication record. Moreover she/he is an expert in at least one
of the
following: OMICS data analysis and integration, QSAR, read-across,
statistical modelling, network inference.
Applications including
i)
a research statement,
ii)
a CV and
iii)
a cover letter including names of at least two referees,
can be sent via email to dario.greco(at)tuni.fi
by the 30th of May 2019.
GrecoLab is currently involved in the large collaborative projects:
The
laboratory of Dr. Brady Atwood in the Department of Psychiatry at
Indiana University School of Medicine is seeking to fill an immediate
opening for a full-time post-doctoral appointee.
Candidates
should possess a doctoral degree in neuroscience, pharmacology,
physiology or a related field. The postdoc will have opportunities
to learn patch clamp electrophysiology, in vitro and in vivo
optogenetics and animal behavior paradigms.
Research
space will be in the new Neurosciences Building; investigators in this
building have access to state-of-the-art Core Facilities.
The department and the university place a high priority on creating a
diverse learning environment and on supporting the professional
development of ethnic minorities, women, veterans, and people with
disabilities. Applications are encouraged from professionals
of all ethnic backgrounds.
Please email Dr. Brady Atwood at bkatwood@iu.edu for
further information. If interested, please email your CV and the contact information for at least 3 references.
Make a real difference in the fight against infectious diseases. Biopromic AB (http://biopromic.com/
) strive to develop Point of care testes for rapid diagnosis of
infectious diseases. Our portfolio covers several important know-how and
technologies for the development of different test platforms of
importance in the fields of human and veterinary diagnostics.
Duties and responsibilities:
–
Responsible for the methodologies and make sure recipes are available.
–
Preparation of project-and validation documents and reports.
–
Expertise in immunoassays development (ELISA, Lateral flow and other), and provide technical support to the rest of the team.
–
Actively involved in troubleshooting in R&D daily work.
Requirements and qualifications:
–
PhD in Biomedical Science or equivalent.
–
At least 4 years experience as a scientist i a field of diagnostic research and development.
–
Experience in biochemistry, cell culturing, chromatography, assay development and validation and immunoassays.
–
Excellent command of the English language in both verbal and written,
–
Experience in development of monoclonal antibodies – from cell culture to purification and QC
–
Accountable: Prioritize your work and take responsibility for your own tasks and supporting others in the team.
–
Experience of work according to GMP is a merit.
–
Accurate and meticulous in daily work and delivering according to plan.
We look forward to reading your application with full CV!
Location: Solna/Stockholm, Sweden
Application deadline: 2019-05-15
Submit your application to:
careers@biopromic.comusing a code SS2019
in the title of your email.
FULLY FUNDED 2-YEAR POSTDOCTORAL POSITION IN THE VALVANO GROUP
A
Postdoctoral Fellow position for an individual with training and
demonstrated abilities in cell biology/cellular immunology/cellular
microbiology is
available in the Valvano group to investigate the inflammasome in human
CFTR-defective macrophages and monocytes.
Project summary:
Infection and chronic inflammation in patients with cystic fibrosis
(CF) lead to progressive lung damage. CF-defective macrophages fail to
kill engulfed opportunistic pathogens such as Burkholderia cenocepacia.
Engulfed pathogens disarm macrophages and counteract immunity by
deploying proteins (effectors) that alter central
cellular pathways including actin cytoskeleton remodeling.
Pathogen-induced disorganization of the actin cytoskeleton is both a
remarkable anti-host strategy and a danger signal driving inflammation
and cell death. However, the actin cytoskeleton dynamics
in the context of the CF defect has not been explored. We hypothesize
that intracellular opportunistic pathogens engulfed by macrophages, in
combination with the CF genetic defect, induce disorganization of the
actin cytoskeleton that leads to a
highly
proinflammatory state. Our research established B. cenocepacia as a
model organism for cellular microbiology. We discovered that a B.
cenocepacia
type VI-secretion system (T6SS) disrupts the macrophage’s actin
cytoskeleton and elicits pyroptosis (proinflammatory cell death), and we
recently identified TecA as the T6SS protein responsible for these
phenotypes by causing the direct inactivation of Rho
GTPases, which in turn activates the Pyrin inflammasome and the ASC
complex formation. We will
investigate
here the relationship between inflammation and B. cenocepacia-mediated
modulation of macrophages’ actin cytoskeleton in CFTR-defective human
monocytic macrophages. We will address 2 specific aims: (1) To assess
the status of the pyrin inflammasome in B. cenocepacia-infected,
CFTRdefective peripheral monocytes; and (2) To evaluate the role of the
B. cenocepacia T4SS and T2SS systems in the activation
of ASC-dependent inflammasomes upon infection in human macrophages.
Interested applicants should contact Prof. Miguel A. Valvano at
m.valvano@qub.ac.uk
and provide a CV, brief statement of interest, and references.
The
University of Helsinki is an international scientific community of
40,000 students and researchers. It is one of the leading
multidisciplinary research universities in Europe and ranks among
the top 100 international universities in the world.
HOH
Helsinki One Health is a new network organization, led by the Faculty
of Veterinary Medicine and cooperated by four other faculties at the
University of Helsinki, to co-ordinate research actions
within the area of One Health. One Health is a globally emerging
concept recognizing that the health of humans and animals is
interconnected and that their populations share the essentials of life:
the genome, disease causing organisms, health, welfare, and
the environment. HOH Helsinki One Health involves different disciplines
and professions to work together to resolve emerging health problems
concerning human and animal populations worldwide. In addition to other
profiling actions, HOH Helsinki One Health
will host several tenure track professorships with their established
research environments in years 2018-2022. Please see:
https://www.helsinki.fi/en/one-health.
We invite applications for the position of an
ASSISTANT PROFESSOR / ASSOCIATE PROFESSOR / PROFESSOR IN EMERGING INFECTIOUS DISEASES
This
is a joint position between the Faculty of Medicine and the Faculty of
Veterinary Medicine. The research and teaching field of the
professorship is microbiology, infectious diseases and vaccines.
Introduction
Blueprint Genetics is
on a mission to bring world-class genetic knowledge to mainstream
healthcare. To meet the challenges imposed by our rapid growth, we are
looking for new Geneticists to join our Clinical
Interpretation Team. We are a team of experienced professionals with
diverse backgrounds who share the passion for helping patients and
families suffering from inherited disorders. Our constantly evolving
diagnostic portfolio currently includes over 200 tests
that cover a wide variety of clinical specialties and diagnostic
approaches, including Whole Exome Sequencing. We work with hundreds of
clinics around the globe and the quality of our interpretation has been
praised by many of the world’s best medical centers.
If you have the ambition to be among the pioneers of the molecular era
of medicine, you might be the person we are looking for.
Job description
The position involves
interpretation and reporting of findings from our clinical molecular
genetic tests, including panel-based tests, Whole Exome Sequencing and
targeted variant tests. Our Geneticists also
participate in the development and validation of products and
applications in a project team environment. Those interested get to
collaborate with our Software Engineers and Data Scientists with the
development of our proprietary software tools that enable
us to interpret identified variants efficiently by utilizing artificial
intelligence and machine learning.
The ideal candidate has:
Clinical
Laboratory Geneticist degree or Board certification in Clinical
Molecular Genetics / Laboratory Genetics and Genomics or Ph.D. in
Genetics.
Experience
in interpreting and reporting genetic test results in a clinical
setting utilizing NGS, Sanger sequencing and other methods is an asset,
but similar research experience is valued as well.
Knowledge of current genomic information and variant databases is essential
Fluent skills in oral and written English are a necessity
Great attention to detail
Critical thinking when reviewing scientific literature
Effective planning and organization skills
Excellent follow-through abilities
Experience in working under certified and accredited quality management systems is an asset.
Fitting the immediate, low-hierarchy and positive Blueprint culture
What we offer
At Blueprint Genetics,
you get to be a valued part of our global and multidisciplinary team of
people who want to make a difference. You will be working daily to
bring your expertise from base pairs to bedside
for improved patient outcomes. We offer you a rapidly evolving working
environment where you can learn and grow together with a unique company
and great colleagues. You get to use everything you have learned in an
environment that is unlike anything you have
experienced before.