Ajankohtaista

Postdoctoral Fellow position available in the Department of Neuroscience at the Medical University of South Carolina

14.8.2019 | Avoimet työpaikat

Postdoctoral Fellow position available on a NIDA T32 training grant to pursue a collaborative study in the laboratories of Dr. Jacqueline McGinty and members of the Addiction Research Center in the Department of Neuroscience at the Medical University of South Carolina (https://education.musc.edu/MUSCApps/facultydirectory/Mcginty-Jacqueline )

The primary goal of the study is to characterize the role of pathway-specific neurons originating in the prefrontal cortex of rodents during and after drug (cocaine, heroin) self-administration using viral –mediated DREADD expression, in vivo electrophysiology, calcium imaging, and dendritic spine analyses. The next stage of research is to determine if normalizing the proteins and physiological processes affected by addictive drugs during early abstinence can prevent subsequent relapse.

Contact information:

Jacqueline F. McGinty, Ph.D.

Professor, Dept of Neuroscience

Director, MUSC Brain Research Institute


Medical University of South Carolina
email mcginty@musc.edu

Salary commensurate with NIH guidelines. Must be a US citizen or resident (green card) to be eligible for a NIH T32 position.

Open position for a Senior Researcher (Post-doctoral fellow) in Thyroid Research at the Institute of Biomedicine, University of Turku

13.8.2019 | Avoimet työpaikat

A post-doctoral job is available at the Research Centre for Integrative Physiology and Pharmacology, in docent Jukka Kero´s Thyroid group at the Institute of Biomedicine, University of Turku, Finland. The Department is well equipped with facilities for modern molecular and cell biology research. The close connection with Turku Center for Disease Modeling (TCDM) offers excellent facilities and infrastructure to perform experiments with genetically modified disease models. We are looking for a highly motivated senior researcher or a postdoc with strong experience in molecular biology, genetics and experimental disease models. The group focuses on molecular mechanisms of thyroid disorders. We are studying thyroid genetics in patients with congenital or hereditary thyroid diseases via in silico, in vitro methods, or genetically modified disease models.

The research project focuses on novel gene mutations and testing their pathogenicity in vitro and in vivo. The work involves analyzing next-generation sequencing data and generation and phenotyping of new disease models. The researcher will closely work with technicians and PhD-students in the group.

There is a trial period of four months. The position is planned for 2-4 years and could start in autumn 2019 or as negotiated.

The informal application should include CV,motivation letter (max one page),and recommendation letter.

For further information about the position, please contact docent Jukka Kero (jukka.kero(at)utu.fi)

Postdoctoral Positions in Chemical Neurobiology and Neuropeptide Physiology in the Banghart Laboratory, Neurobiology Section at the University of California San Diego

13.8.2019 | Avoimet työpaikat

The Banghart Lab at UCSD seeks to fill two NIH-funded Postdoctoral Fellowship positions to study neuropeptide signaling in the mammalian brain. Fellows will contribute to team-based, multi-institutional molecular tool-development efforts in addition to pursuing independent research projects. Technologies under development include photoactivatable neuropeptides, precision pharmacological reagents, and neuropeptide sensors. Our physiological studies aim to understand the role of several neuropeptides in pain modulation, and molecular mechanisms that govern neuropeptide secretion in the brain. This work is funded by the NIH Brain Initiative, NIDA and NIGMS.

The Chemistry position requires expertise in synthetic organic chemistry and the ability to independently plan and carry out the synthesis and analysis of new molecules. Some experience with peptide chemistry and/or light-sensitive molecules is highly desired. Candidates should be highly independent in the hood and comfortable being surrounded by neurobiologists. Interest in contributing to biological evaluation of new probes is a plus. Applicants should hold a Ph.D. or equivalent degree in chemistry or chemical biology.

The Neurobiology position requires experience in molecular biology, cell culture and fluorescence microscopy. Additional experience with G-protein coupled receptors, intracellular signaling, electrophysiology, rodent behavior, and/or stereotactic surgery is highly desirable. Candidates must be willing to work as part of a team to contribute to collaborative tool-development projects while also pursuing an additional independent research project that exploits the resulting technologies. Applicants should hold a Ph.D. or equivalent degree in biology, pharmacology, neuroscience or related fields.

The Banghart Lab is located in the Center for Neural Circuits and Behavior (CNCB), which is the hub of UCSD Neuroscience community. We are proud to work in a highly interactive research environment that embraces diversity and work-life balance in addition to scientific excellence. Both positions will offer opportunities to write grants, train students and present findings at professional conferences. Salary will be a minimum of $50,760 according to UCSD guidelines.

Candidates should send their CV and the names of 3 references to mbanghart@ucsd.edu. 

www.banghartlab.org

https://postdoc.ucsd.edu/
https://pda.ucsd.edu/

Open position for a Postdoctoral Researcher in Statistical / Computational Genomics at the Centre of Excellence in Complex Disease Genetics, Insitute for Molecular Medicine Finland FIMM

13.8.2019 | Avoimet työpaikat

FIMM is currently seeking

Postdoctoral Researcher in Statistical / Computational Genomics at the Centre of Excellence in Complex Disease Genetics

for a fixed-term of two years with a possibility of extension for a third year

Description:

Revealing the molecular mechanisms underlying common complex diseases holds the promise of improved and targeted prediction, prevention, diagnosis and treatment. Building on unique resources and an extensive track record in disease genetic studies in Finland, the Academy of Finland Centre of Excellence in Complex Disease Genetics (CoECDG), hosted at the Institute for Molecular Medicine Finland (FIMM) at HiLIFE and the Faculty of Medicine, develops and applies a powerful and general strategy for comprehensive identification of risk and protective variants and leads national efforts to implement genomic findings into prevention and personalised treatment of common complex diseases.

The CoECDG is searching for outstanding postdoctoral candidates to work with data-driven computational projects related to the CoE focus areas:

1) Tools for prediction and prevention of complex diseases
2) Tools for personalised management of complex diseases
3) Role of genetics in pathways through major life-course health events

Apply at the latest on August 16th 2019.

For further information about the position, please visit our website or our research group websites or contact Assist. Prof. Matti Pirinen (matti.pirinen(at)helsinki.fi). For the potential correspondence, please use the following topic in your subject field “CoECDG OPEN POSTDOC POSITION”.

https://www.fimm.fi/en/open-position/postdoc-statistical-computational-genomics
https://www.helsinki.fi/en/researchgroups/centre-of-excellence-in-complex-disease-genetics/open-positions

PhD student position – Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles

9.8.2019 | Avoimet työpaikat

Laboratory of Stem Cells and Cancer‐ Université Libre de Bruxelles
http://blanpainlab.ulb.ac.be/

PhD student position
4 years grant (2 years renewable), starting October 2019


Our laboratory is located on the medical campus (Erasme) of Université Libre de Bruxelles (Belgium) and is headed by Prof. Cédric Blanpain. This project will be performed under supervision of Dr. Alexandra Van Keymeulen and in close collaboration with Dr.Christel Pequeux at Université de Liege.


Research Project
Approximatively 75% of breast cancers are estrogen dependent and estrogen receptor‐positive (ER+). Despite the large efficacy of anti‐estrogen treatments, relapse occurs in 30% of cases. In addition, estrogens remain the most powerful treatment to circumvent menopause symptoms. However, their use as menopause hormone treatment (MHT) remains controversial since MHT is associated to an increased risk of breast cancer. A better understanding of the ER signaling upon estrogen or anti‐estrogen treatment in mammary gland and during breast tumorigenesis is thus crucial to develop new tools to target these cancers and to develop a new generation of MHT.


In this context, we aim at answering the following questions:
Aim 1: What is the impact of estrogen signaling on the transcriptional and chromatin landscapes of
the ER+ and ER‐ epithelial cells during tumorigenesis?
Aim 2: Which mechanisms are promoting breast cancer upon MHT treatment during menopause?
Aim 3: How come estetrol treatment during menopause does not promote breast cancer, while it prevents side effects of menopause?


These experiments will constitute a novel and comprehensive definition of the transcriptional and chromatin landscapes of purified individual cell lineages during tumorigenesis and upon MHT. Our results will constitute the basis to highlight new potential targets to treat luminal‐like breast cancer and will also provide precious information to assess how estetrol could safely replace estradiol use as MHT, without increasing breast cancer risk. Finally, they will open new avenues to prevent hormone‐dependent tumorigenesis.


Methods: in vivo models of mammary gland and breast cancer (MMTV‐PyMT, PDX, cell line xenografts), FACS cell sorting, RNAseq, ATACseq, Chipseq, qPCR, 3D cultures.


Skills: Master degree in Biomedical science, molecular biology, biochemistry or equivalent, FELASA certification. High motivation, enthusiasm and scientific curiosity are mandatory. Ability to learn fast,
to work independently, meticulous, good communication would be appreciated.

Contact: To apply, send a motivation letter, a C.V. and two references with their email address to
Alexandra Van Keymeulen (avkeymeu@ulb.ac.be)


Open position for a Postdoctoral researcher in cell biology and laboratory automation at the University of Helsinki

9.8.2019 | Avoimet työpaikat

The Faculty of Medicine promotes scientific research of a high standard and is responsible for providing research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, as well as for the English-language Master’s Programme in Translational Medicine. In addition to its teaching and research activities, the Faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. In terms of research, the Faculty aims for a place among the best medical faculties in the world, while consolidating and strengthening its status as a top-level institution of medical education.

Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.

The Faculty of Medicine is seeking a

POSTDOCTORAL RESEARCHER IN CELL BIOLOGY AND LABORATORY AUTOMATION
https://www.helsinki.fi/en/open-positions/postdoctoral-researcher-in-cell-biology-and-laboratory-automation

Dr. Simon Pfisterer is setting up a new research group at the Department of Anatomy, Faculty of Medicine, University of Helsinki, and is looking for a highly motivated postdoctoral researcher to join his multi-disciplinary team.

Hypercholesterolemia, an elevated blood concentration of low-density lipoprotein (LDL) increases the risk for cardiovascular disease, which is one of the most common causes for death worldwide. Individuals respond differently to LDL lowering medications. Currently, we do not understand the cellular defects underlying increased blood LDL concentration and how different responses to LDL lowering therapies arise in individual patients.

It is the goal of the research team to set up state-of-the-art laboratory automation tools to elucidate cellular mechanisms underlying the development of hypercholesterolemia. For this purpose, we will establish a work environment where cell biological research is truly merging with laboratory automation and programming.

We are looking for a highly motivated individual with a commitment to excellence to join this dynamic and collaborative research team. Ideal candidates have a strong background in cell and molecular biology and are eager to acquire new skills such as automated image and data analysis. Key requirements are experience in human cell culture methods, molecular cloning (e.g. generation of expression plasmids), and fluorescence microscopy. Experience in Python programming or automated image analysis are a plus. A PhD degree in Life or Biological sciences, or an MD PhD degree, as well as excellent communication skills in spoken and written English, are required.

We provide opportunities to develop both transferable and scientific skills, with strong support from your laboratory colleagues, and competitive salary (3100-3600 euros/month).

The application, together with the required attachments, must be submitted through the University of Helsinki electronic recruitment system by clicking the Apply for job -link. Internal applicants (i.e. current employees of the University of Helsinki) must submit their applications through the SAP HR portal.

The application should include a cover letter describing previous achievements and motivation for the position (1 page), CV, track record of peer-reviewed publications, and names and contact details of two referees.

The position will be filled once a suitable candidate has been identified. The initial appointment is for one year starting as soon as possible, with the possibility of extension. A six-month trial period will be applied.

Further information is available from simon.pfisterer(at)helsinki.fi

Recent publications:

1.Pfisterer, S. G. et al. Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage. Nat. Commun. 8, 14858 (2017).
2.Sandhu, J., Pfisterer S.G. et al. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Cell 175, 514-529.e20 (2018).
3.Pfisterer, S. G., Peränen, J. & Ikonen, E. LDL-cholesterol transport to the endoplasmic reticulum: current concepts. Curr. Opin. Lipidol. 27, 282–287 (2016).

Due date 01.09.2019 23:59 EEST

Apply the position

Tutkijatohtori tai projektitutkija, mikrobiologia – Jyväskylän yliopisto

9.8.2019 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=2&id=00007630&lang=fi

Jyväskylän keskustassa sijaitsevan yliopiston kauniilla puistokampuksella sykkii monitieteinen ja moderni tiedeyliopisto – ihmisläheinen ja dynaaminen yhteisö, jonka 2 500 asiantuntijaa ja 15 000 opiskelijaa etsivät ja löytävät vastauksia huomisen kysymyksiin. Jyväskylän yliopisto on ollut tulevaisuuden palveluksessa jo vuodesta 1863, jolloin suomenkielinen opettajankoulutus sai alkunsa täältä. Voimanlähteenämme on moniarvoinen vuoropuhelu tutkimuksen, koulutuksen ja yhteiskunnan välillä. Vaalimme tutkimuksen ja koulutuksen tasapainoa sekä ajattelun avoimuutta – sytytämme taidon, tiedon ja intohimon elää viisaasti ihmiskunnan parhaaksi.

Bio- ja ympäristötieteiden laitoksella on haettavana

tutkijatohtorin tai projektitutkijan tehtävä, mikrobiologia, alkaen 1.10.2019 tai mahdollisimman pian sen jälkeen, kahden vuoden määräajaksi.

Bio- ja ympäristötieteiden laitoksella tutkimus jakautuu biotieteisiin ja ympäristötieteisiin. Laitoksen vahvuusalueita ovat evoluutiontutkimus ja biologiset nanotieteet sekä luonnonvarojen ja ympäristön tutkimus. Evoluutiobiologinen tutkimus on suuntautunut evoluutioekologiaan ja evoluutiogenetiikkaan. Laitoksen eri alojen välillä on runsaasti yhteistyötä ja laaja-alaiset tutkimuskohteet kattavat niin DNA-, eliö-, populaatio- kuin ekosysteemitasonkin. Tutkimustoiminnalle on luonteenomaista ennakkoluuloton eri biologian alojen yhdistäminen ja empiirisen tutkimuksen korostaminen. Perus- ja soveltava tutkimus kulkevat luontevasti rinnakkain.

Etsimme tutkijatohtoria (FT) tai projektitutkijaa (FM) tutkimusryhmäämme. Projektissa selvitämme konjugatiivisesti kuljetettavan CRISPR-Cas9 plasmidin ja bakteriofaagien yhteisvaikutusta antibioottivastustuskyvyn poistamisessa bakteeriyhteisöistä. Tutkimme myös resistenssigeenien horisontaalista siirtymistä monimutkaisissa bakteeriyhteisöissä, jotka altistuvat erityyppisille valintapaineille. Yhteisöt näitä tutkimuksia varten muodostetaan pääosin ulostenäytteistä. 

Tutkijatohtorin ja projektitutkijan tehtävistä, kelpoisuusvaatimuksista ja kielitaidosta määrätään yliopiston johtosäännössä ja kielitaito-ohjeistuksissa. Tutkijatohtorilta edellytetään hyvää englannin kielen taitoa.

Etsimme motivoitunutta hakijaa, jolla on koulutus molekylaarisessa mikrobiologiassa tai vastaavalta alalta. Päivittäinen tutkimustyö sisältää perusmikrobiologian tekniikoita, ddPCR analyyseja, sekvensointia ja plasmidien geneettistä muokkausta. Arvostamme kokemusta tilastoanalyyseissa, bioinformatiikassa, sekä kykyä työskennellä itsenäisesti ja osana tutkimusryhmää.

Tutkijatohtorin tehtävä asettuu yliopistojen palkkausjärjestelmän opetus- ja tutkimushenkilöstön tehtävien vaativuustasolle 5-6. Palkkasi on noin 3111 – 4381 euroa kuukaudessa riippuen aiemmasta osaamisestasi ja kokemuksestasi. Projektitutkijan tehtävä asettuu yliopistojen palkkausjärjestelmän opetus- ja tutkimushenkilöstön tehtävien vaativuustasolle 3-4. Palkkasi on noin 2367 – 3245 euroa kuukaudessa riippuen aiemmasta osaamisestasi ja kokemuksestasi. 

Tehtävää täytettäessä käytetään kuuden kuukauden koeaikaa. 

Lisätietoja antaa: Akatemiatutkija Matti Jalasvuori, matti.jalasvuori@jyu.fi.

Sähköiseen hakulomakkeeseen tulee liittää:

  1. Ansioluettelo (CV), joka laaditaan hyvää tieteellistä käytäntöä noudattaen sekä ottaen huomioon mahdollisuuksien mukaan ansioluettelomalli (ks. TENK:n ohje). Ansioluetteloon pitää liittää myös kahden varttuneemman akateemisen suosittelijan yhteystiedot
  2. Lyhyt hakemuskirje, sisältäen omat tutkimusintressit/-suunnitelman
  3. Julkaisuluettelo
  4. Tutkintotodistukset

Hakemus tulee jättää viimeistään 18.8.2019 sähköisellä hakulomakkeella.

Two postdoc positions in comparative evolutionary genomics at the University of Lausanne

24.6.2019 | Avoimet työpaikat

The Groups of Profs Christophe Dessimoz and Robert Waterhouse are seeking candidates for two 3-year Postdoctoral positions at the Departments of Computational Biology and Ecology & Evolution, University of Lausanne, Switzerland, funded by the Swiss National Science Foundation (SNSF).

Working at the interface between biology and computer science, the Dessimoz Lab, https://lab.dessimoz.org/, seeks to better understand evolutionary and functional relationships
between genes, genomes, and species.

The Waterhouse Group, https://rmwaterhouse.org/lab, is focused on elucidating interactions between gene evolution and gene function through computational interrogation of arthropod genomics data.

Both Groups are members of the SIB Swiss Institute of Bioinformatics, https://www.sib.swiss/

The two Postdocs will lead the evolutionary genomics contributions to a groundbreaking interdisciplinary project in collaboration with the Group of Prof. Bruno Lemaitre, https://lemaitrelab.epfl.ch/ , at the neighbouring École Polytechnique Fédérale de Lausanne.

The overall project aims to develop the computational tools required to fully exploit new genomics data in a framework that also takes advantage of the latest molecular biology tools to achieve combined evolutionary and functional characterisation of the Drosophila immune system. The two Postdocs will work closely together on the project developing and applying
comparative genomics and evolutionary modelling approaches to fully exploit new genomics data, with a biological focus on the insect innate immune system.

The evolutionary genomics part of the project will focus on

(1) extending our current knowledge of immune effectors beyond the canonical repertoires of genes encoding for known antimicrobial peptides, and

(2) exploiting the rich genomics datasets across Drosophila species to trace the evolutionary histories of immune genes.

We seek candidates with demonstrated programming skills in the areas of bioinformatics, computational biology, and comparative genomics.

 Further desirable attributes include knowledge of and interest in orthology delineation, gene family evolution, phylogenetics, gene birth/death, genome-wide synteny, selection and constraint, gene prediction, genome annotation, immunity, infection, insects.

Applications can only be made through the University of Lausanne online recruitment platform , where the full job descriptions will be posted shortly. To ensure full consideration, applications should be received by 30 June 2019.

Note that the SNSF defines the position of ‘Postdoc’ as no more than five years since obtaining a doctorate (i.e. since the doctoral thesis defence).

Informal enquiries can in the meantime be made by writing to:
Prof. Christophe Dessimoz, Christophe.Dessimoz@unil.ch
Prof. Robert Waterhouse, Robert.Waterhouse@unil.ch

Päällikkö, biopankki – liity auttamisen ketjuun! Haemme Veripalvelun biopankkitoiminnoille määräaikaista vetäjää.

24.6.2019 | Avoimet työpaikat

Haemme Veripalvelun biopankkitoiminnoille määräaikaista vetäjää.
https://www.veripalvelu.fi/meille-toihin/avoimet-tyopaikat/p%C3%A4%C3%A4llikk%C3%B6-biopankki

Suomessa toimii tällä hetkellä kymmenen biopankkia, joista kaksi toimii Veripalvelussa: Hematologinen biopankki, jonka omistavat Helsingin yliopisto, Hematologi yhdistys ja Veripalvelu, sekä Veripalvelun Biopankki, joka rekrytoi verenluovuttajia. Biopankit ovat biolääketieteellistä tutkimusta tukevia alustoja, joihin kerätään biopankkisuostumuksen antaneiden henkilöiden näytteitä ja tietoja tulevaa tutkimusta varten. Biopankit toimivat osana Veripalvelun tutkimus ja tuotekehitys -osastoa ja ovat viranomaisvalvonnan alaisia.  

Tehtäväsi

Keskeisinä tehtävinäsi ovat:

  • biopankin operatiivisesta toiminnasta vastaaminen ja sen kehittäminen
  • aineistopyyntöjen käsittelyyn liittyvät tehtävät ja asiakasprosessien kehittäminen 
  • sidosryhmäyhteistyö  
  • biopankin henkilöstön esimiehenä toimiminen

Tehtävä on määräaikainen sijaisuus ja päättyy 31.12.2020. Tehtävässä voi aloittaa sopimuksen mukaisesti.

Osaamisesi

Odotamme hakijalta tehtävään soveltuvaa ylempää korkeakoulututkintoa, sekä valmiuksia toimia tiiminvetäjänä ja vastata aineistopyyntöjen käsittelystä. Tehtävän hoitaminen vaatii hyviä vuorovaikutustaitoja, monipuolisia teknisiä valmiuksia ja vahvaa englannin kielen taitoa. Eduksi luetaan kokemus biopankki- ja tutkimustoiminnasta sekä kansallisen toimintaympäristön tuntemus ja kokemus viranomaisten säätelemästä toiminnasta.  

Tarjoamme

Tarjoamme haastavan ja merkityksellisen työn innostavassa ja osaavassa työyhteisössä. Olet osa ainutlaatuista auttamisen ketjuamme vapaaehtoisten luovuttajien sekä terveydenhuollon henkilökunnan kanssa. Käytössäsi ovat Veripalvelun monipuoliset henkilöstöedut. Työyhteisön hyvinvointi on meille erityisen tärkeää ja haluamme olla työntekijöillemme erinomainen työpaikka.

Lisätietoja tehtävästä antaa tutkimusjohtaja Jukka Partanen, jukka.partanen@veripalvelu.fi  tai p. 050-3707383.

Jätä hakemuksesi viimeistään 4.7.2019 tämän linkin kautta.  ​

Postdoc in Genomics Discovery and Epidemiology – Novo Nordisk Foundation, Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen

20.6.2019 | Avoimet työpaikat

https://jobportal.ku.dk/alle-opslag/?show=149712

The University of Copenhagen is seeking a highly motivated and talented postdoctoral fellow to commence 1 October 2019 or as soon as possible thereafter at the Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences.

The postdoctoral fellowship is part of the Novo Nordisk Foundation Center for Basic Metabolic Research International Postdoctoral Program www.cbmr.ku.dk/postdocprogram.

The postdoctoral fellow will receive a competitive package including salary and running costs for three years, and be part of an international scientific collaboration at the Maersk Tower www.maersktower.ku.dk.

Job description

The fellowship is aimed at early career researchers with a basic science background or clinicians who aspire to a career in academic medicine. We are particularly interested in candidates who are familiar with integrative research approaches within the broad area of basic metabolic research with an application towards human pathophysiology. The Center’s vision is to strengthen interdisciplinary research that transforms the basic understanding of mechanisms involved in metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. Information about the Center can be found at www.cbmr.ku.dk.

The postdoc position is in the Genomics Discovery and Epidemiology Group headed by Associate Professor Tuomas Kilpeläinen. The research group investigates how genetic variation contributes to obesity and related metabolic disorders and interacts with the environment, modifying the effect of physical activity, diet, and other lifestyle factors on weight gain and metabolic health. You can read more about the Kilpeläinen Group at www.cbmr.ku.dk/research/human-genomics-and-metagenomics-in-metabolism/kilpelainen-group.

Project description

Insulin resistance, dyslipidaemia, and increased risk of type 2 diabetes are closely linked to obesity, but there is wide individual variability in the metabolic tolerance for carrying excess body fat. Among patients who are morbidly obese, up to 10% do not show any sign of metabolic dysfunction at all. In contrast, lipodystrophic patients who are unable to form subcutaneous adipose tissue, typically suffer from severe insulin resistance and other metabolic abnormalities. Overfeeding experiments have shown that given similar relative weight gain, individuals may be either protected from or predisposed to metabolic dysfunction. Furthermore, results from weight loss interventions for type 2 diabetes have shown that non-overweight individuals respond to substantial weight loss just as well as the obese in terms of conversion to normal glucose tolerance.

The aim of the present project is to examine the role of genetic variation in the individual relationship between adiposity and metabolic dysfunction in human populations. We expect that the postdoc will develop a project that, through the understanding of the role of genetic diversity, will elucidate the causal mechanisms that couple obesity to metabolic dysfunction and open avenues for identifying individuals with the highest risk of developing insulin resistance and type 2 diabetes if they gain weight.

Profile

We are looking for a highly motivated and enthusiastic scientist with the following competencies and qualifications:

  • Experience in statistical programming (e.g. R, SAS)
  • Expertise in applying statistical analyses to test biological hypotheses
  • Experience in epidemiological research
  • Strong interest in research on obesity and metabolic disorders
  • Proven track record showing continuous scientific productivity in peer-reviewed journals
  • Interest in co-supervising PhD fellows and MSc students
  • Excellent English communication skills, both written and oral

Eligibility

The applicant must hold a PhD within a relevant discipline such as medicine, biology, biochemistry, molecular biology, bioinformatics, pharmacy or medical engineering. The PhD degree must preferably be awarded from a university outside of Denmark. The program is also open for applicants with a Danish PhD degree who can document at least 12 months full-time research experience from outside Denmark.

You are not eligible to apply for the program if you have been employed in a postdoctoral position for more than one year at the University of Copenhagen prior to the commencement of the fellowship.

Selection

Selection of postdoctoral fellows is based on academic achievements, research experience and interviews. A mandatory interview visit for the shortlisted applicants comprises interviews with PI and co-PI and a tour of the Center facilities. The Center will pay for travel and accommodation for selected applicants in association with the interview visit.

The University of Copenhagen International Staff Mobility office offers support and assistance to all international researchers on all issues related to moving to and settling in Denmark. Read more at www.ism.ku.dk and www.workindenmark.dk.

The applicant must fulfil the following criteria:

  • A strong CV, having published in high-impact journals and presented at international meetings
  • An enthusiastic interest in basic metabolic research
  • The ability to manage your own academic research and associated activities
  • The ability to contribute ideas for new research projects
  • Evidence of excellent interpersonal skills and leadership, with the ability to communicate research ideas and results in a clear and logical way and the ability to confidently and effectively interact with colleagues and the broader research community

Terms of employment

The employment as postdoc is a full time position for 3 years. Starting date is 1 October 2019.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

Questions

For further information about the position, please contact Associate Professor Tuomas Kilpeläinen at tuomas.kilpelainen@sund.ku.dk. Questions regarding the CBMR International Postdoctoral Program must be directed to cbmr@sund.ku.dk. For questions regarding the recruitment procedure, please contact SUND HR CBMR at mlr@sund.ku.dk.

Application procedure

Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

  • Cover letter expressing the motivation and previous research experience of the applicant (max 1 page)
  • Curriculum vitae
  • Copy of the PhD degree certificate and the Master degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor is acceptable
  • List of publications
  • References (name and contact details of at least two references)

The application deadline is 7 July 2019 at 23.59pm CET.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether an unbiased assessor has passed their application for assessment. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at www.employment.ku.dk/faculty/recruitment-process.

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen wishes to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.