Ajankohtaista

Postdoctoral Researcher, cell and molecular biology – Institute of Biomedicine, University of Eastern Finland (Kuopio campus)

https://duunitori.fi/tyopaikat/tyo/postdoctoral-researcher-cell-and-molecular-biol-stse-10431399

The University of Eastern Finland, UEF, is one of the largest multidisciplinary universities in Finland. We offer education in nearly one hundred major subjects, and are home to approximately 15,500 students and 2,500 members of staff. We operate in Joensuu and Kuopio. In international rankings, we are ranked among the leading universities in the world.

The Faculty of Health Sciences operates at the Kuopio Campus of the University of Eastern Finland. The Faculty offers education in medicine, dentistry, nutrition and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognised research activities are closely linked to the strategic research areas of the University. There are approximately 2 500 degree students and about 450 PhD students in the Faculty. The faculty has 680 staff members. http://www.uef.fi/en/ttdk/etusivu

We are now inviting applications for

a Postdoctoral Researcher (cell and molecular biology), School of Medicine, Institute of Biomedicine, Kuopio Campus

An Academy of Finland funded Postdoctoral Researcher position is available in the laboratory of Dr Kirsi Ketola at the Institute of Biomedicine, UEF School of Medicine. The laboratory’s translational research programme aims at understanding the mechanisms, detection and targeting of highly aggressive treatment-resistant cancer subtypes, such as neuroendocrine prostate cancer.

The projects employ multi-disciplinary approaches including modern cell and molecular biology techniques ranging from high-content cellular imaging and screening to next generation sequencing, epigenetics and drug discovery. We are seeking a highly motivated candidate with experience in cellular imaging, bioinformatics and/or biomarker and drug discovery. Experience in prostate cancer biology, bioassay development or single cell analyses on lineage reprogramming (imaging, sequencing) is an asset.

The position gives opportunities to take part, along with the group leader, in supervising PhD and MSc students, scientific writing, grant applications, scientific collaborations and teaching in suitable areas. Outstanding communication skills are required.

A person to be appointed as a postdoctoral researcher shall hold a suitable doctoral degree. Positions of postdoctoral researchers shall always be filled for a fixed term (UEF University Regulations, Section 31).

The person to be appointed to the Postdoctoral Researcher Position is required to hold a doctoral degree, which may not have been completed more than five years ago at the time of accepting the position. In this context, the 5 years refer to a net period of time, which does not include maternity leaves, parental leaves, or military service, etc.

The language requirements associated with the position are defined in the Government Decree 770/2009. Members of the university’s teaching and research staff are required to have command of the language they give teaching in (Finnish or Swedish). The Dean of the faculty may grant an exemption from the language proficiency requirements laid down in the Government Decree.

The position is filled for a fixed-term of 3 years with a possibility of extension. The full-time position will start in September 2019, or later by agreement. Positions of postdoctoral researchers shall always be filled for a fixed term (UEF University Regulations, Section 31).

The salary of the position is determined in accordance with the salary system of Finnish universities and is based on level 5 of the job requirement level chart for teaching and research staff (€2,935.55/ month). In addition to the job requirement component, the salary includes a personal performance component, which may be a maximum of 50 % of the job requirement component.

For further information on the position, please contact: Academy Researcher Kirsi Ketola, email: kirsi.ketola@uef.fi, phone +358 29 4454098. For further information on the application procedure, please contact

HR Secretary Tellervo Rajanto, email: tellervo.rajanto@uef.fi, phone +358 29 4454278.

A probationary period is applied to all new members of the staff.

The electronic application should contain the following appendices:

– a résumé or CV

– a list of publications

– motivation letter

– copies of the applicant’s academic degree certificates/diplomas, and copies of certificates/diplomas relating to the applicant’s language proficiency, if not indicated in the academic degree certificates/diplomas

The application needs to be submitted no later than 5.8.2019 (by 24.00 hours Finnish time) by using the electronic application form.

WWW-osoite http://www.uef.fi
Yhteystiedot Academy Researcher Kirsi Ketola, email: kirsi.ketola@uef.fi, phone +358 29 4454098. For further information on the application procedure, please contact
Työpaikan osoite 70211 KUOPIO
Työaika kokoaikatyö
Työn kesto yli 12 kuukautta
Haku päättyy 05.08.2019
Ilmoitus jätetty 19.06.2019
Ilmoitusnumero 10006817

Post-Doctoral Positions in Drug Abuse/Pain Research at the University of Michigan

We are currently seeking Post-Doctoral Fellows with experience in preclinical and cellular models of drug abuse and/or pain. Ongoing projects are related to the understanding of substance abuse, the development of medications the management of opiate and/or cocaine abuse and pain. The selected candidates may be eligible to join  our NIH  training grant on the Biology of Drug Abuse (seehttps://sites.google.com/umich.edu/bda/home).

Candidates should have strong communication skills and technical expertise, with a focus on either in vitro (e.g., cell signaling, immunohistochemistry, electrophysiology) or in vivo (e.g., self-administration or pain models, circuitry analysis) methods. An ability to integrate in vivo and in vitro findings will be an advantage. Applicants should have completed (or be about to complete) an MD or Ph.D. or equivalent degree in a relevant discipline (e.g., biochemistry, pharmacology, neuroscience, biological psychology, physiology etc.) and must be US citizens or permanent residents of the USA.

Positions are available starting late summer/early fall. For more information contact John Traynor (jtraynor@umich.edu) or Emily Jutkiewicz (ejutkiew@umich.edu) or speak to Emily or John at the INRC meeting.

To apply, e-mail an up-to-date CV with the names of 3 referees to jtraynor@umich.edu.

2 postdoctoral positions and 2 graduate student positions at the University of Oulu

Two postdoctoral positions (application and more information in the link):

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00007562&lang=en

Two open postdoctoral researcher positions are available in the field of molecular cancer cell biology, systems genetics and functional genomics in the research groups led by Drs Aki Manninen (www.oulu.fi/biocenter/groups/manninen) and Gonghong Wei (www.oulu.fi/biocenter/groups/wei) at the Faculty of Biochemistry and Molecular Medicine (FBMM), Biocenter Oulu, University of Oulu, Oulu, Finland. We are looking for ambitious, highly motivated candidates who have enthusiasm and ability to work hard both independently and as a team member to tackle challenging problems to achieve common goals. The positions are funded for 3 years.

This project aims at characterizing integrin-associated molecular machineries driving cancer-promoting effects in prostate cancer cells focusing on the crosstalk between hemidesmosomes and focal adhesions. Transcriptional regulatory mechanisms of integrins, as well as crosstalk between integrin signaling, androgen receptor pathway and other relevant prostate cancer associated pathways will be investigated. Genomic analysis will focus on systems identification of causal genetic variants, causative genes and relevant pathways as well as their functional and biological effects on prostate cancer susceptibility, initiation and progression.

The project utilizes 3D cell culture models where, in addition to established prostate cancer cell lines, we develop novel study systems based on prostate cancer patient-derived prostate organoids. The candidates will also employ advanced microscopy techniques, virus-based genomic engineering, CRISPR-Cas9-mediated genome editing and state-of-art cancer genetics and functional genomics approaches. Further reading: Myllymäki et al., (2019), MCP, doi: 10.1074/mcp.RA118.001095.; Gao et al., (2018), Cell, 174:576-589.; Huang et al., (2014), Nat Genet. 46:126-135.; Zhang, K. et al. (2017) Oncogene, doi: 10.1038/onc.2017.177. 

Two PhD-student positions (application and more information in the link):

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00007583&lang=en

Applications are invited for two full-time doctoral student positions for a maximum of four years, starting at the earliest on 01.01.2020 in a Biocenter Oulu research project headed by Professors Gonghong Wei and Aki Manninen in the cancer genomics research unit, Faculty of Biochemistry and Molecular Medicine.

Our work aims to discover the roles of novel transcription factors and epigenetic regulators in cancer predisposition and progression, and to explore how these proteins misregulate genome-wide gene expression in particular during prostate cancer development. We also focus on the identification of causal genetic variants, genes and relevant pathways as well as their functional and biological effects on prostate cancer susceptibility, initiation and progression.

The positions will be supervised by Professors Gonghong Wei and Aki Manninen and are focused on mapping genome-wide binding sites (cistrome) for novel transcriptional regulators in prostate cancer cells and tissues. We will further investigate the cistrome-enriched prostate cancer risk-associated variants and thus integrate the eQTL, epigenome and three-dimensional (3D) genome data to unravel the biological roles of causal variants and genes. Functional validation of selected genetic variants, target genes and other relevant risk factors will be performed using genetically engineered prostate cancer models. The projects utilize 3D cell culture models, potential patient-derived prostate organoids/xenografts, mouse models, advanced microscopy techniques, viral gene transfer-based genomic engineering, and CRISPR-Cas9-mediated genome editing as well as other molecular cell biology methods and functional genetics/genomics approaches.

PhD within molecular developmental biology – Nord University, Bodø, Norway

https://www.researchgate.net/job/931235_PhD_within_molecular_developmental_biology

PhD fellowship is available at the Faculty of Biosciences and Aquaculture, Nord University (Bodø, Norway) on the project: Biogenesis and functions of small regulatory RNAs in embryonic development of zebrafish.

The position is for 3 years and will be available from August 1st. 2019.

The PhD is in molecular developmental biology, and zebrafish is the primary model. Regulation of early embryonic development is a multifaceted process involving many classes of regulatory elements. Ambiguity of developmental origin of these elements is a major difficulty in studying their functional roles This study combines functional genomics and high-throughput sequencing approaches in order to identify biogenesis, expression features, and roles of chosen elements. The focus is on two classes of small regulatory RNAs: miRNA and piRNA, which are both present in the early embryo yet their roles are poorly determined.

We offer

The annual salary for doctoral researchers is set from wage level 51 ( 449.400) in the Norwegian State Salary Scale.

• Advantages within the Government Pension Fund for borrowing, insurance and pension
• Creative and collegial working environment
• A workplace with steady progressive development
• Flexible working hours
• Active university sports team

General information

The person who is appointed must abide by the applicable laws, agreements, and directives. The responsibilities and duties associated with the position may change with future reorganization at Nord University.

The public sector workforce is expected to reflect the diversity of the population in general. Nord University therefore encourages qualified candidates with disabilities, gaps in their CV, immigrant backgrounds or different life experience to apply. Nord University practices moderate allocation according to gender quotas in accordance with the Basic Agreement for State Employees.

If applicants indicate they have disabilities or gaps in their CV, their details may be used anonymously for the purposes of recording whether this target is achieved or not.

Contact information

Further information about the position can be obtained by contacting :

Professor Igor S. Babiak, e-mail: igor.s.babiak@nord.no, telephone: +47 75 51 79 22
Office Manager Irene Stork, e-mail: irene.stork@nord.no

Application

Applications must be submitted electronically by June 20th 2019.

The application should include:

• Cover letter outlining the candidate’s suitability for this position (one page), and a project outline based on the project (maximum2 pages)
• must be submitted.
• Curriculum vitae, including a list of publications (maximum 3 pages)
• Certified copies of academic degree transcripts and any other relevant qualifications
• Contact details for 2 – 3 references
• All documents must be uploaded as attachments to the electronic application form.
• Signed consent form PhD (if relevant)

All documents must be uploaded as attachments to the electronic application form.

It is the applicant’s responsibility to submit the complete documentation within the deadline.

After the application deadline, an applicant list will be announced publicly. Applicants asking for confidentiality must specifically explain the reasons for this in their application. Even so, the information can be published if the reasons for confidentiality are not found relevant. In such the case, an applicant will be given notice prior to the announcement, and he/she will have opportunity to withdraw the application

Refnr. 30085016
Applicationdeadline: 20.06.2019

The candidate should have an MSc degree (or equivalent) in natural sciences, preferably in one of the following fields: Developmental Biology; Molecular Cell Biology; Genomics; Bioinformatics.Education and experience in one or more of the following areas is required: molecular developmental biology, RNA biology, transcriptomics, or genomics.Hands-on experience in RNA-seq, RNA bioinformatics, epigenomics, non-coding RNAs, or zebrafish development are advantageous for the position.Proficiency in oral and written English is essential and must be documented either by the Norwegian Higher Education Entrance Qualification or internationally recognised certificates, such as TOEFL, IELTS, APIEL or similar. Skills in Scandinavian language is an advantage for the position.The selected candidate will join the PhD programme in Aquatic Biosciences at Nord University and is expected to complete a doctorate within the three-year project period. The candidate should fulfill the admission requirements of this PhD programme at the Faculty of Biosciences and Aquaculture and participate in the training components stipulated in regulations of the PhD program. Application for admission to the programme must be submitted within three months after taking up the position. For admission requirements and regulations, see our see our web page.

Nord University

Global challenges demand new insight, innovative solutions and local legitimacy. Nord University is a young university with strong regional ties and a global perspective. We are committed to delivering relevant educational programmes and research, with a focus on blue and green growth, innovation and entrepreneurship, and welfare, health and education. Nord University has 12,000 students and 1,400 employees at nine study locations in central and northern Norway.The Faculty of Biosciences and Aquaculture (FBA) educates people who promote sustainable and innovative development to meet global challenges in food production, climate and environment. The Faculty is an international arena for education, research and knowledge dissemination, with employees and students from 25 different countries. The Faculty offers a PhD in Aquatic Biosciences. The Faculty of Biosciences and Aquaculture has 900 students and 150 employees in Bodø and Steinkjer. The professional community is organised into the following divisions: Aquaculture, Ecology, Genomics and Animal Science, Production and Welfare.Read more: www.nord.no/en/fba

Postdoctoral Research Fellow in Haematopoietic Stem Cell Research – UiT The Arctic University of Norway

https://www.researchgate.net/job/930361_Postdoctoral_Research_Fellow_in_Haematopoietic_Stem_Cell_Research

About the position

At the Faculty of Health Sciences, the Department of Medical Biology a position has become available for a Postdoctoral Research Fellow in Haematopoietic Stem Cell Research. The position is affiliated with the research group Stem Cell Aging and Cancer.

The group aims at understanding malignant haematopoietic stem cell behaviour and regulation. Our goal is the identification of novel therapeutic targets of potential clinical interest. We use a variety of state-of-the-art techniques, including novel mouse genetic tools, stem cells, omics and advanced imaging. Our group has a broad international network and strengthens translational research through established collaborations with the University Hospital of North Norway (UNN). For more detailed information: www.uit.no/research/sac

This Postdoctoral position is a fixed term position of a duration of two years. Appointment to the positon of Postdoctoral Research Fellow is mainly intended to provide qualification for work in academic positions. It is a prerequisite that the applicant is able to carry out the project over the full course of the employment period. No person can hold more than one fixed-term position as a Postdoctoral Research Fellow at the same institution.

More than 200 staff members from all over the world have their workplace at the Department of Medical Biology (IMB). The Department consists of 13 research groups concentrating on fundamental biomedical research problems, including research on various cancer forms, cardiovascular diseases, the body’s immune system and antibiotic resistance. The Department is also involved in marine bio-prospecting and testing of new drugs.

IMB provides education for students studying medicine, dentistry, biomedical laboratory sciences, biomedicine and pharmacy.

Responsibilities

Acute myeloid leukaemia (AML) is a highly aggressive haematopoietic malignancy often associated with poor response to chemotherapy and outcome. It has been proposed that the presence of mutations in at least two genes that specifically confer a survival advantage to the haematopoietic stem cell (HSC) and impede its further differentiation is required for AML development. This suggestion is based on the fact that oncogenes that confer a survival advantage to the HSC and are frequently mutated in human AML are only able to induce myeloproliferative neoplasms in mouse models but not the transition to AML.

The successful candidate will contribute to understand the process of HSC malignant transformation, aiming at using this knowledge for better patient treatment. Further project details will be directly discussed with the applicants.

Contact

The contact person for this position is Group Leader and NCMM Young Associate Investigator Dr. Lorena Arranz:

• phone: +47 77 62 08 41
• e-mail: lorena.arranz@uit.no

We offer

• Interesting work tasks and science of excellence
• A highly competitive academic environment with dedicated colleagues
• Good career opportunities
• A large degree of independence in work
• Pension scheme through the state pension fund

Application

The application must include:

• cover letter including a short description of interests and reasons for applying for the position
• CV containing a complete overview of education, experience, professional work and references
• Diplomas and certificates:     
  • diploma and transcript of Bachelor’s degree or equivalent (in original language and translated)
  • diploma and transcript of Master’s degree or equivalent (in original language and translated)
  • Diploma and transcript of PhD
• list of academic works
• up to 15 academic works. The doctoral thesis is here counted as one work.
• description of the attached works, and a short description of other works to show breadth of output.

It is expected that the successful candidate shall prepare a project description and progress reports some months after commencing employment.

Applications will only be considered if all requested application documents are received before the application deadline. Applications sent to us via e-mail or by any other means will not be considered.

Al documentation to be assessed must be translated into English or a Scandinavian language.

Assessment

The applicants will be assessed by an expert committee. The committee’s mandate is to undertake an assessment of the applicants’ qualifications based on the application documents and the text of the announcement.

The applicants who are assessed as best qualified will be called to an interview. The interview shall, among other things, aim to clarify the applicant’s personal suitability for the position and motivations.

UiT is seeking to increase the proportion of women in its academic positions. If two or more applicants are found to be generally equally qualified, the university will prioritise a female over a male candidate.

Working and payment conditions

Working hours will be set aside for research, research-related activities and research administration.

The successful candidate must also be willing to get involved in the ongoing development of their department and the university as a whole.

The remuneration for this position is in accordance with the State salary scale code 1352 A compulsory contribution of 2% to the Norwegian Public Service Pension Fund will be deducted.

General

In addition, applicants shall also refer to the supplementary provisions for the appointment to academic positions such as Postdoctoral Research Fellow, Research Fellow and Academic Assistant at UiT, The Arctic University of Norway, and to regulations concerning terms and conditions of employment for the posts Postdoctoral Research Fellow, Research Fellow, Research Assistant and Resident.

Questions concerning the organisation of the working environment, including that of the physical state of the workplace, health services, possibilities for flexible working hours, part-time work, etc. may be addressed to the telephone reference in this announcement.

At UiT, The Arctic University of Norway, diversity is valued, and we therefore encourage all qualified applicants to apply regardless of their age, gender, functional ability or national or ethnic background. UiT is an will make the necessary adaptations in order to facilitate for employees with reduced functional ability.

Personal information given in an application and CV will be treated in accordance with the Act relating to the processing of personal data (the Personal Data Act). In accordance with section 25, subsection 2 of the Freedom of Information Act, the applicant may request not to be registered on the public list of applicants. However, the university may nevertheless decide to make the candidate’s name public. The applicant will receive advance notification of any such publication.

You can find more information on the website for arriving staff.

We look forward to receiving your application.

Deadline: 31. July 2019

About UiT The Arctic University of Norway

UiT – Developing the High NorthUiT The Arctic University of Norway is a multi-campus research university and the northernmost university of the world. Our central location in the High North, our broad and diverse research and study portfolio, and our interdisciplinary qualities make us uniquely suited to meet the challenges of the future. At UiT you can explore global issues from a close-up perspective.

Credibility, academic freedom, closeness, creativity and commitment shall be hallmarks of the relationship between our employees, between our employees and our students and between UiT and our partners.

The Faculty of Health Sciences

The Faculty of Health Sciences is a national innovation which brings together a wide range of health-related education pathways.This lays the groundwork for a unique level of interdisciplinarity and innovation in health education and research. We work closely with northern services in order to find solutions for tomorrow’s challenges.

Postdoc position, Maintenance of neuronal identity – Karolinska Institutet

https://www.researchgate.net/job/930283_Postdoc_position_Maintenance_of_neuronal_identity

Job description The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.

Division
The research group of Johan Holmberg is part of the Department of Cell and Molecular Biology (CMB) which recently moved to the new interdisciplinary research centre Biomedicum located at Campus Solna, Karolinska Institutet.

Background
The brain contains a large number of different neuronal subtypes that maintain their distinct identities over several decades despite continuous environmental fluctuation. Apart from the instructive information provided by transcription factors controlling cell type specific transcriptional programs, there is presumably also a need to maintain silencing of alternative transcriptional programs. The mechanisms governing permanent repression of aberrant transcription in mature neurons are not well understood. Our lab focuses on the role of repression of alternative gene programs for lifelong maintenance of serotonergic and dopaminergic identity. For a more extensive background see: Holmberg and Perlmann, Nature Review Genetics 2012and Södersten, E. et al. Nature Commun. 2018. Besides exploring fundamental processes we also aim to understand how they influence clinically relevant topics including psychiatric disorders, neurodegeneration and aging. The group also harbour an interest in the understanding of the paediatric malignancy, neuroblastoma, see: Westerlund, et al. Proc Natl Acad Sci U S A 2017.

In this project we will generate and analyse large amounts of data from defined wild type/mutant mouse neuronal populations in order to understand the functional relevance of gene repression for safeguarding mature serotonergic and dopaminergic identity.

Position specific requirements
We are looking for an outstanding researcher able to analyse and integrate large sets of bulk and single cell RNA-seq with ChIP-seq data generated from restricted in vivo neuronal subpopulations. Additional experience with confocal image acquisition and analysis as well as with in vivo/in vitro standard methods (e.g. immunostaining, FACS, stereotactic injections, behavioural analysis and cell culture) will be considered as a distinct advantage. Thus we are primarily looking for a computational biologist with experience/interest in laboratory/animal work or an experimental biologist with extensive bioinformatic skill and interest.

The applicant must be able to communicate well in English.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• Cover letter stating the motivation to apply and key skills that match the profile 

The application is to be submitted on the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements. Reference number 2-2626/2019 Contact

• Johan Holmberg, johan.holmberg@ki.se

Published 30.Apr.2019 Last application date 30.June.2019 11:59 PM CET

Open position for a doctoral student in Structural Biology at the University of Oulu

The University of Oulu (http://www.oulu.fi/english/) is one of the largest universities in Finland, with approximately 15 000 students and 3 000 employees. The University of Oulu Graduate School (UniOGS) (http://www.oulu.fi/uniogs/) provides the framework and conditions for high-quality, research-driven doctoral education at the University of Oulu, and field-specific doctoral training is provided by its multidisciplinary doctoral programmes. Biocenter Oulu (BCO) (http://www.oulu.fi/biocenter/) offers a high-level international multidisciplinary environment supplied with cutting-edge infrastructures. Under this framework, the Health and Biosciences Doctoral Programme (HBS-DP) (http://www.oulu.fi/uniogs/dp/hbsdp) offers doctoral training in clinical medicine, biomedicine, biochemistry, molecular medicine, dentistry, health sciences, and medical technology.

Subject field and the description of the position
Applications are invited for a full-time PhD student position for a maximum of four years, starting on January 1^st 2020, in a Biocenter Oulu research project headed by Professor Petri Kursula in the Biomedical Structural Biology research unit, Faculty of Biochemistry and Molecular Medicine.

Our main focus is the structural biology of the myelin sheath. Most myelin proteins are either integral or peripheral membrane proteins, often involved in either autoimmune or inherited demyelinating disease. We also have a keen interest in other structural biology problems, including protein-membrane interactions at the molecular level, high-resolution crystallography, and the structural basis of various neurological diseases. More details can be found at https://www.uib.no/en/rg/petrikursula.

The position is supervised by Prof. Petri Kursula and Dr. Salla Ruskamo and is focused on the 3D molecular and atomic structure of the myelin sheath, as well as the molecular mechanisms of mutations causing human hereditary neuropathies.

Required Qualifications and assessment
To successfully occupy the PhD student position, the candidate must possess an MSc degree in biochemistry, biophysics, protein science, or another relevant field. Practical experience in protein research will be highly valued, and a keen interest in biophysics and structural biology are required. The MSc degree must have been completed with good grades by December 2019, preferably by the call deadline. Ability to pursue independent research as a member of a team and excellent oral and written communication skills in English are expected.

The position is intended for an Early Stage Researcher (ESR) who, according to the ”European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers”, is defined as a researcher in the first four years (full-time equivalent) of his/her research activity, including the period of research training. Applicants will be either starting their doctoral training, or will have completed no more than two full years of training (adjusted for possible previous part-time status) at the time the position is filled. The selected candidate will carry out his/her doctoral studies in the HBS-DP of the UniOGS and must meet the minimal requirements to receive doctoral study rights as defined in http://www.oulu.fi/uniogs/requirements_for_admission.

Salary
The salary of the selected doctoral student will be initially set on level 2, and later on levels 2 – 4, of the national salary scale for the teaching and research staff of Finnish universities. In addition, a supplementary remuneration is given for personal achievement and performance (max. 50 %). In practice, the salary is roughly 2200 – 2700 € per month for an early stage researcher, depending on qualifications and progress of the doctoral thesis.

Since this call is for a starting PhD student, the position will be filled for a four-year period, beginning on 1 January 2020. A six-month trial period will be applied in the position.

Application procedure
Applications, together with all relevant enclosures, must be submitted using the electronic application system by July 19th, 2019. Applications sent by email will not be considered. Apply at https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00007516&lang=en

The following documents must be attached to the application (in English)

1. Complete CV containing the contact information of 2-3 sources for references (Max. size of the attachment: 5 Mbytes)
2. Motivation letter (maximum 1 page) describing prior experience, research interests, and career plans (1-2 pages; max. size of the attachment: 2 Mbytes).
3. Certificates/Diplomas: Scanned electronic copies of diplomas and transcripts of the records of relevant previous degrees. If the original documents are not in English, Finnish, or Swedish, each document must be accompanied by an official certified translation into English or Finnish. (Max. size of the attachment: 2 Mbytes)

Other relevant information
Eligible applicants fitting best in the expected research profile will be invited to an on-site or remote interview. All applicants will be notified when the selection process is completed.

Contact
Prof. Petri Kursula, e-mail: petri.kursula(at)oulu.fi

Open position for a doctoral student in FETopen MindGAP project, University of Oulu

Research Scientist – miDiagnostics, Leuven, Flemish Region, Belgium

https://www.linkedin.com/jobs/view/1289763911/?refId=3d7d4545-14be-43c7-8f4c-a58933feed15&trk=eml-vjr-similar-job-title&midToken=AQFgumZyIt6sOQ&trkEmail=eml-email_jobs_viewed_job_reminder_01-null-37-null-null-41f64x%7Ejwcdutfn%7E2y-null-jobs%7Eview

You will be part of a dynamic, international and multidisciplinary team that develops a completely new medical diagnostic device to be used at the point of need. As “Process Development Technician” you will support processing activities related to back-end processing of the silicon-based nFP. You will generate the necessary data and knowledge to make the transition from test prototypes to market ready products. You will also provide the development teams with the necessary components to support the prototype manufacturing and testing needs.

Responsibilities

You will become part of a team of scientists and engineers that is developing a new device for molecular diagnostic testing. In your role of Molecular Biologist, you will develop and optimize new assay principles for nucleic acid purification, extraction, amplification and detection on a silicon chip. In particular, you will:

• Develop new methods for nucleic acid extraction within a silicon chip
• Develop new methods for nucleic acid amplification and detection
• Develop new sample prep methodologies to purify nucleic acids from diverse clinical sample specimens
• Design and optimize assays to be run on the silicon chip
• Interact with silicon chip designers and process engineers to match the silicon chip to the needs of the molecular biology and vice versa
  
  

Profile and competences:

• You have a MSc or PhD degree in molecular biology, (bio)chemistry engineering or bioscience engineering
• Ideally, several years of experience in PCR, assay design and/or other ways of nucleic acid detection technologies
• Experience in de novo assay development, not based on existing kits, is a plus
• A keen interest in novel technologies for molecular diagnostics
• A thorough understanding of chemistries related to nucleic acids and solid phases is a plus
• Experience in microfluidics is a strong plus
• Hands-on and resourceful problem solver is a must
• Attention to detail, works in a structured and methodological way
• Team-player
• Excellent communicator
• Fluent in English

Principal Scientist, Genetics – Novo Nordisk, Måløv, DK

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Bioinformatics and Data Mining, Global Research Technologies

Denmark – Måløv

Do you like working on the intersection between biology and data, and drive the use of genetics for drug discovery? Then this job might be right for you. We are looking for a scientist with deep expertise in using human genetics, experience for drug discovery, strong leadership skills, and the ability to lead our representation in key external partnerships and consortia to support our drug discovery pipeline.

About The Department

The Department of Bioinformatics and Data Mining combines strong computational skills with biological insights through the integrative analysis of internal and external biomedical data. Our analytical expertise spans a wide range of areas, from genetics, sequence analysis, many different omics, pathway analysis, to text-mining. We contribute to all aspects of pre-clinical research projects at Novo Nordisk, where we act as data-driven experts and participate in external collaborations with academic and biotech partners. Our work results in real impacts on new medicines for highly important diseases of unmet medical need.

The position

Your main responsibility will be to work closely with our scientists in Global Research to drive the application of human genetics in drug discovery to positively impact the success of our R&D pipeline. As such you will have extensive expertise in human genetics, especially in the context of drug discovery. This will allow you to define strategies for acquisition and analysis of relevant human genetic and genomic data, as well as interpretation and communication of results.

Qualifications

• Ph.D. in statistical genetics, genetic epidemiology, statistical bioinformatics, or a related field, with a minimum of 5 years post-PhD experience
• Deep experience in analyses of human genetic and phenotypic data, interpretation of genetic associations, and use of functional annotation to identify drug targets and disease mechanisms
• Proficiency in at least one general purpose programming language suitable for statistical genetic analyses (e.g. R or Python)
• Demonstrated skills in leading multidisciplinary teams to find creative ways to address scientific questions in drug discovery
• Strong record of achievement as reflected in peer-reviewed publications
  
  

Contact

For further information, please contact Martijn van de Bunt +45 30 75 02 64

Deadline

June 9th 2019

Millions rely on us
To work for Novo Nordisk you will need the skills, dedication and ambition to change lives for the better for millions of patients living with diabetes and other chronical diseases. In exchange, we offer the chance to be part of a truly global workplace, where passion and engagement are met with opportunities for professional and personal development.