Ajankohtaista

Research Scientist, Cell Biologist Metabolism – Hays, Stockholm, Sweden

https://www.linkedin.com/jobs/view/1284652296/?refId=3d7d4545-14be-43c7-8f4c-a58933feed15&trk=eml-vjr-similar-job-title&midToken=AQFgumZyIt6sOQ&trkEmail=eml-email_jobs_viewed_job_reminder_01-null-29-null-null-41f64x%7Ejwcdutfn%7E2y-null-jobs%7Eview

Research Scientist – Cell Biologist Metabolism

Hays specialist recruitment is now looking for a candidate to a 12 month assigment as a Research Scientist to our client AstraZeneca in Mölndal. The assigment is to start with a 12 months assigment with good chances  to extension and permanent employment.

Hays specialist recruitment is a global recruitment company that has been based in Sweden since 2003. Hays has a world wide network whitin the business areas and is passionated about people and your career. Would you like to read more about Hays visit our website www.Hays.se.

AstraZeneca is a major international healthcare business engaged in the research, development,

manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services.

AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives – and are made to feel valued, energized and rewarded for their ideas and creativity.
The area

Your will be working within the CVMD iMed Bioscience department, which is a multi-discipline

department working with metabolic, cardiovascular and kidney diseases. The drug hunting activities also spans into many different modalities including small molecules, peptide and nucleotides.

This provides scientists with a unique opportunity for innovation in drug discovery.

You will be part of the metabolism in vitro group in Bioscience and focusing on questions within drug

discovery project in diabetes and NASH areas.

The Cell Biologist Metabolism supports drug discovery

projects with scientific input in the in vitro assay strategy and delivers key in vitro and ex vivo

decision-making data.
Major responsibilities:

• Independently apply existing in vitro and ex vivo assays for projects during different phase of

projects.

• Independently design and execute in vitro or ex vivo experiments

• Statistical analysis and interpretation of generated data

• Presentation of data at the team and project team level

• Document the work according to AstraZeneca standards, and prepare the preclinical

pharmacology part of regulatory documents as appropriate.

• Work collaboratively with in vivo, DMPK, etc scientists as required to ensure flow-scheme

connectivity and translatability between in vivo and in vitro models

• Work collaboratively within Bioscience and iMed to deliver on project key questions.

• Contribute proactively to a vibrant and innovative working environment where improvements

and new ideas are adopted and freely shared.

• Ensure compliance with corporate code of conduct guidance and other safety standards.
Minimum requirements

• Broad expertise in cell biology & biochemistry

• Experienced in establishing/performing cell-based assays.

• Cell culture, ELISA, western blot, and qPCR experience is a must

• Experience with primary cell culture, measurements of cellular respiration, and knowledge of

adipose and liver cell biology is an additional advantage.
Looking forward to see your application!

Postdoc Positions Available – Augmented Exosomes for Cardiac Repair, AstraZeneca, Sweden

https://job-search.astrazeneca.com/job/gothenburg/postdoc-fellow-augmented-exosomes-for-cardiac-repair/7684/12059369

Location: Gothenburg, Västra Götaland County, Sweden Job reference: R-046184
Posted date: May. 31, 2019
Apply

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. We’re proud to have a unique workplace culture that inspires innovation and collaboration. We believe in the potential of our people and you’ll develop beyond what you thought possible.

The new R&D Oncology organisation brings together early and late oncology teams, from discovery through to late-stage development, with oncology specific Regulatory and Biometrics groups.

You’ll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career.

Our Discovery Sciences team operates from truly state-of-the-art centres spanning the UK, US and Sweden. You’ll work with some of the most knowledgeable technological experts in the industry, all collaborating on high-profile drug discovery projects.

Extracellular vesicles represent an exciting opportunity for delivery of complex RNA-based drugs, and since 2015 we have been working with a team of postdocs on developing new technologies for drug loading, targeting and functional delivery using extracellular vesicles. We now have openings for three new postdocs working on 1) delivery of mRNA, 2) targeting to heart, and 3) developing innovative in vitro and in vivo models of heart disease to explore the action and underlying biological mechanisms of engineered extracellular vesicles in a therapeutic setting. The internal postdoc work at AstraZeneca is supported through collaborations with leading academic experts.

Myocardial infarction (MI) results in severe damage to the heart muscle tissue with scar formation and irreversible loss of cardiac function leading to the development of heart failure. Encouraging results have been achieved with cell therapy to regenerate the heart tissue and improve function, but there is accumulating evidence that these beneficial effects are mainly mediated by extracellular vesicles. We propose to study the action of engineered extracellular vesicles from human IPS-CPCs (cardiac progenitor cells) and from adult stem cells in vitro (angiogenesis, cardiomyocyte proliferation, apoptosis) and in rodent models of MI in vivo. We will engineer extracellular vesicles to carry additional (known and novel) stimulatory factors to augment their biological activity (e.g. VEGF-A, mRNA coding for genes driving proliferation, etc.). We have developed novel cell-based and in vitro technologies for EV loading with proteins and RNA, which will be exploited in this project (focus for postdoc-1). We will explore targeting of extracellular vesicles to heart tissue (focus for postdoc-2) with known and novel ligands and examine improved drug exposure to heart tissue. We will multiplex in vivo experiments with extracellular vesicles by bar-coding technology for bio-distribution studies. In addition, we have a separate recruitment ongoing in CVRM for a 3rd AZ postdoc working on the development of novel in vitro and in vivo regenerative models of heart disease. The three postdocs will work closely together on the shared goal of developing novel opportunities around the use of engineered extracellular vesicles for therapeutic treatment of heart disease. As a postdoc you will also get the opportunity to try novel techniques and ideas. We will also support development of leadership skills and deeper understanding of drug development process.

Education and Experience required:

Essential:

• A PhD in biological sciences with a strong cell biology or biochemical focus.
• A strong scientific track record, as evidenced by published papers in high quality peer-reviewed journals.
• Excellent organizational, communication and interpersonal skills, combined with the ability to work collaboratively across boundaries and problem solve in the absence of complete information.
• Entrepreneurial ways of working

Desirable:

• Experience of cell imaging, confocal microscopy, FACS and RT-PCR
• Experience with in vivo experiments and bio-distribution
• Experience with EV drug loading (postdoc-1) and/or drug targeting (postdoc-2)

Skills and Capabilities required:

• Working experience of isolation, characterization and manipulation of extracellular vesicles.
• Excellent expertise with mammalian cell culture including iPSC and adult stem cells, general molecular biology techniques, RNA biology, and protein engineering.
• Experience working with proteomics and transcriptomics data
• Strong oral and written communication skills

This is a 3 year programme.  2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based. There are 2 vacancies for engineering of extracellular vesicles (e.g. postdoc-1 and -2). The roles will be based in Gothenburg, SE, with a competitive salary on offer. To apply for this position, please click the apply link below.

Advert opening date – 31st May 2019 / Advert closing date – 9th August 2019

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Senior Research Fellow/Postdoctoral Researcher, Medical Microbiology and Immunology – University of Oulu

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00007430&lang=fi

Senior Research Fellow/Postdoctoral Researcher position is available in the field of Medical microbiology and immunology in the Research Unit of Biomedicine, at the Faculty of Medicine, University of Oulu (http://www.oulu.fi/medicine/ ).

Research Environment

The University of Oulu in Northern Finland, with approximately 16,000 students and 3,000 employees, is an international, multidisciplinary research university with a rich pool of creative and intellectual talent. The strengths of the University include broad, multidisciplinary research interests, a modern research and study environment, and wide cooperation with international research and educational institutes (http://www.oulu.fi/university/ ).

Subject field and description of the position

The research field for the position will be medical microbiology and immunology. The duration of the position is for 5 years. The starting date is August 1, 2019, or as soon as possible thereafter. A six-month trial period will be effective in the beginning of the 5-year contract.

The successful applicant must hold a PhD degree in biomedicine, or related discipline.

Fluency in both written and spoken English, experience in writing scientific publications, teaching experience as well as good communication and teamwork skills are required. Activity in the scientific community, supervision experience, ability to participate teaching preferably in Finnish and potential in acquiring supplementary funding will be taken as merits.

Furthermore, an applicant for the Senior Research Fellow position should have postdoctoral experience in the relevant research field (preferably including mobility) and demonstrated ability for research supervision and acquiring supplementary funding. As part, the duties also include supervising scientific research of BSc, MSc, and PhD students. Participation in teaching in medical microbiology and immunology, and in acquiring research funding are expected.

Salary

The salary will be based on level 6 or 7 (Senior Research Fellow) or level 5 (Postdoctoral Researcher) of the demand level chart for university-level teaching and research staff of Finnish universities. In addition, a salary component based on personal work performance will be paid (maximum of 50 % of the job-specific component).

Application Procedure

The following documents must be attached to the application (in English):

1) Curriculum vitae

2) List of publications

3) Brief description of research merits and experience

4) Description of teaching merits

5) Contact information of two persons who may be asked to give a statement of the candidate

Applications, together with all relevant enclosures, must be submitted using the electronic application system form by June 9th, 2019.

Applications sent by email will not be considered.

More information

Professor Timo Hautala

timo.hautala@oulu.fi

Doctoral (PhD) student position in Reproductive Toxicology at Karolinska Institutet

Doctoral (PhD) student position in Reproductive Toxicology at Karolinska Institutet

We are recruiting a doctoral (PhD) student. For more information regarding doctoral education at Karolinska Institutet (KI), see: http://ki.se/en/phd/about-doctoral-education-at-ki

A doctoral student is admitted to third-cycle/doctoral education. A doctoral education consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

Research group
The doctoral education project will be carried out in Associate Professor Pauliina Damdimopoulou’s research laboratory at the Division of Obstetrics and Gynecology at the Department of Clinical Science, Intervention and Technology of Karolinska Institutet. Research and education at the Division of Obstetrics and Gynecology are focused on the many aspects of women’s reproductive health as well as fetal physiology and stem cell biology.

Damdimopoulou laboratory is located at the Campus Flemingsberg of Karolinska Institutet and focuses on human ovarian biology as well as effects of toxic chemicals on fertility.

The doctoral student project and the duties of the doctoral student
The doctoral education project will be carried out within the Horizon2020 project FREIA (http://www.freiaproject.eu/ ), which rises from a concern that environmental factors can affect a woman’s chances of becoming pregnant. Hence, the ambition of FREIA is to develop novel identification and screening approaches for endocrine disrupting chemicals (EDCs) that target female fertility. The aim of this doctoral education project is to study the effects of EDCs on human ovarian follicle growth in vitro and identify associated adverse outcome pathways. Cross-species validation will be carried out by comparing the findings to rat studies carried out in FREIA. In addition, ovarian transcriptomics datasets will be used to understand possible age-dependent differences in chemical toxicity. The work will require visits to laboratories of co-supervisors in Finland, Denmark and Estonia.

The duties of the doctoral student include cell and tissue culture, gene expression analyses and histological analyses. In addition, the student will assist in collection and analyses of rat ovaries and oocytes. The project also involves analyses of RNA-seq datasets. Techniques utilized will include in vitro culture of human ovarian tissue samples, isolation and culture of primary ovarian cells, immunostaining, fluorescent microscopy and histomorphometric analyses, as well as bioinformatics analyses in R.

More information and application at https://ki.mynetworkglobal.com/en/what:job/jobID:273819/?fbclid=IwAR2OXCXXaosNq1LSndOxsCftVXdwRSN5XgMqookT60uHSWbm2uqup52GSfs

Last application date is June 20, 2019 11:59 PM CET.

Postdoc position in Translational Immuno-Oncology at the University of Helsinki

The immuno-oncology research team coordinated by Dr Jeroen Pouwels at the University of Helsinki Faculty of Medicine is looking to hire an ambitious

Postdoc in Translational Immuno-Oncology

The candidate will join a collaborative immuno-oncology project funded by an Academy of Finland project grant of Dr Jeroen Pouwels that seeks new ways to sensitize breast cancer to immune checkpoint inhibitors. The very translational research group is part of the Translational Cancer Medicine Research Program of the Medical Faculty’s Research Programs Unit (RPU) and is aligned with the Finnish Flagship Programme iCAN. A novel method to grow 3D cultures of intact fragments of patient-derived tissue (Patient-Derived Explant Cultures), which preserves the human tumor microenvironment including the immune-contexture, reflects inter- and intra-patient tumor heterogeneity and, importantly, can assess the efficacy of novel treatment regimens on real human tumors (Haikala et al., Nature Comm. 2019; PMID: 30728358), will play a central role in the project.

For more information and to apply, please visit https://www.helsinki.fi/en/open-positions/postdoc-in-translational-immuno-oncology

Deadline for applications is August 5, 2019.

Erikoislaboratoriomestari – Jyväskylän yliopiston liikuntatieteellinen tiedekunta

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=2&id=00007374&lang=fi&fbclid=IwAR1FLy4RK6TWre_YIKKqycxx4ZM4CZk3E5mZJayrrTf3_sW8u_vn5hTACr4

Jyväskylän keskustassa sijaitsevan yliopiston kauniilla puistokampuksella sykkii monitieteinen ja moderni tiedeyliopisto – ihmisläheinen ja dynaaminen yhteisö, jonka 2 500 asiantuntijaa ja 15 000 opiskelijaa etsivät ja löytävät vastauksia huomisen kysymyksiin. Jyväskylän yliopisto on ollut tulevaisuuden palveluksessa jo vuodesta 1863, jolloin suomenkielinen opettajankoulutus sai alkunsa täältä. Voimanlähteenämme on moniarvoinen vuoropuhelu tutkimuksen, koulutuksen ja yhteiskunnan välillä. Vaalimme tutkimuksen ja koulutuksen tasapainoa sekä ajattelun avoimuutta – sytytämme taidon, tiedon ja intohimon elää viisaasti ihmiskunnan parhaaksi.

Haettavana on
erikoislaboratoriomestarin tehtävä 1.8.2019 alkaen toistaiseksi.

Liikuntatieteiden koulutus ja tutkimus on keskitetty maassamme Jyväskylän yliopiston liikuntatieteelliseen tiedekuntaan. Liikuntaa ja terveyttä, niiden välisiä yhteyksiä sekä liikunnan ja terveyden edistämistä tarkastellaan monitieteisesti, päämääränä terveyden, toimintakyvyn ja hyvinvoinnin lisääminen elämänkulun eri vaiheissa.  

Tiedekunnan valtakunnallisiin tehtäviin kuuluu keskeisesti liikunnan- ja terveystiedon sekä terveystieteiden (fysioterapia) opettajankoulutus. Tiedekunnassa on liikuntatieteiden ja terveystieteiden koulutusalat. Tiedekunnassa on kolme tieteenalaryhmää: liikuntabiologia, liikunnan käyttäytymis-yhteiskuntatieteet ja terveystieteet. Tiedekunnassa toimii kolme tutkimuskeskusta: Neuromuscular Research Center, Gerontologian tutkimuskeskus sekä Terveyden edistämisen tutkimuskeskus.  

Erikoislaboratoriomestarin tehtävä sijoittuu liikuntatieteellisen tiedekunnan 10-henkiseen laboratoriotiimiin erityisesti bioanalytiikan osa-alueelle. Erikoislaboratoriomestari tuottaa analyysejä ja kehittää analyysimenetelmiä liikuntatieteellisen tiedekunnan eri tutkimusryhmien tarpeisiin. Erikoislaboratoriomestarin tehtävässä painottuvat ensisijaisesti verinäytteiden ottaminen ja käsittely sekä nukleiinihappo- ja proteiinitason analyysit veri-, kudos- että soluviljelynäytteistä. Lisäksi tehtävään sisältyy laboratorion välinehuoltoon ja yleiseen ylläpitoon kuuluvia tehtäviä yhteistyössä muun laboratoriohenkilöstön kanssa. Erikoislaboratoriomestarin työtehtäviin kuuluu myös laboratoriossa työskentelevien tutkijoiden ja opiskelijoiden (kandidaatti-, maisteri- ja tohtoriopiskelijat) avustamista, neuvontaa ja ohjausta.

Hakijalta edellytetään bioanalyytikon (AMK tai YAMK) tai vastaavaa koulutusta. Hakijan osaamisalueena tulee olla biokemian, solu- ja molekyylibiologian ja genetiikan menetelmät, sekä kokemusta ja näyttöä näiden menetelmien käytännön hallinnasta. Eduksi luetaan kokemus erilaisiin kliinisiin kuormituskokeisiin liittyvistä tehtävistä sekä asiantuntemus solu- ja molekyylibiologisista menetelmistä. Tehtävässä odotetaan myös valmiutta/kyvykkyyttä menetelmien kehittämisessä ja soveltamisessa liikuntatieteelliseen tutkimukseen. Tehtävän menestyksellistä hoitamista edesauttavat hyvä englannin kielen taito, kyky sekä itsenäiseen työskentelyyn että tiimityöhön ja analyyttinen sekä kriittinen oman työn arviointi ja kehittäminen.

Laboratoriomestarin tehtäväkohtainen palkanosa määräytyy yliopistojen palkkausjärjestelmän muun henkilöstön tehtävien vaativuustason 6 (2 092,99 €/kk) perusteella. Lisäksi maksetaan henkilökohtaiseen työstä suoriutumiseen perustuvaa palkanosaa 6-50 % tehtäväkohtaisesta palkanosasta.

Tehtävää täytettäessä käytetään kuuden kuukauden koeaikaa.

Lisätietoja:   akatemiatutkija Eija Laakkonen, eija.k.laakkonen@jyu.fi, puh. +358408053588.

Sähköiseen hakulomakkeeseen tulee liittää:

1) Hakemus
2) Ansioluettelo (cv)
3) Muu liite, jolla hakija haluaa osoittaa kelpoisuutensa ja ansionsa tehtävään.

Hakemus tulee jättää viimeistään 6.6.2019 sähköisellä hakulomakkeella.

Erikoislaboratoriomestari – Jyväskylän yliopiston liikuntatieteellinen tiedekunta

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=2&id=00007391&lang=fi&fbclid=IwAR0Jz5Db0XeisdcSl3vpwgn_qY1PF2024DmkEkpVu3m6jdAYcBSvthTpNjI

Jyväskylän keskustassa sijaitsevan yliopiston kauniilla puistokampuksella sykkii monitieteinen ja moderni tiedeyliopisto – ihmisläheinen ja dynaaminen yhteisö, jonka 2 500 asiantuntijaa ja 15 000 opiskelijaa etsivät ja löytävät vastauksia huomisen kysymyksiin. Jyväskylän yliopisto on ollut tulevaisuuden palveluksessa jo vuodesta 1863, jolloin suomenkielinen opettajankoulutus sai alkunsa täältä. Voimanlähteenämme on moniarvoinen vuoropuhelu tutkimuksen, koulutuksen ja yhteiskunnan välillä. Vaalimme tutkimuksen ja koulutuksen tasapainoa sekä ajattelun avoimuutta – sytytämme taidon, tiedon ja intohimon elää viisaasti ihmiskunnan parhaaksi.

Haettavana on
erikoislaboratoriomestarin tehtävä 1.8.2019 alkaen toistaiseksi.

Liikuntatieteiden koulutus ja tutkimus on keskitetty maassamme Jyväskylän yliopiston liikuntatieteelliseen tiedekuntaan. Liikuntaa ja terveyttä, niiden välisiä yhteyksiä sekä liikunnan ja terveyden edistämistä tarkastellaan monitieteisesti, päämääränä terveyden, toimintakyvyn ja hyvinvoinnin lisääminen elämänkulun eri vaiheissa.  

Tiedekunnan valtakunnallisiin tehtäviin kuuluu keskeisesti liikunnan- ja terveystiedon sekä terveystieteiden (fysioterapia) opettajankoulutus. Tiedekunnassa on liikuntatieteiden ja terveystieteiden koulutusalat. Tiedekunnassa on kolme tieteenalaryhmää: liikuntabiologia, liikunnan käyttäytymis-yhteiskuntatieteet ja terveystieteet. Tiedekunnassa toimii kolme tutkimuskeskusta: Neuromuscular Research Center, Gerontologian tutkimuskeskus sekä Terveyden edistämisen tutkimuskeskus.  

Erikoislaboratoriomestarin tehtävä sijoittuu liikuntatieteellisen tiedekunnan 10-henkiseen laboratoriotiimiin. Erikoislaboratoriomestarin tehtävänä on hallinnoida laboratorioympäristön tila- ja laitevarausjärjestelmää, koordinoida tutkimusprojektien ja opetuksen tarpeita sekä avustaa pienhankintojen ja laitehankintojen tekemisessä. Erikoislaboratoriomestari osallistuu myös suoritus- ja toimintakykylaboratoriossa toteutettavien tutkimusten mittauksiin ja tuottaa niistä perusanalyyseja sekä muutoin avustaa tutkimusten toteuttamisessa. Lisäksi tehtävään voi sisältyä mittauslaitteiden kunnossapitoa ja kehittämistä yhteistyössä teknisen pajan henkilöstön kanssa. Erikoislaboratoriomestarin työtehtäviin kuuluu myös laboratoriossa työskentelevien tutkijoiden ja opiskelijoiden (kandidaatti-, maisteri- ja tohtoriopiskelijat) avustamista, neuvontaa ja ohjausta.

Hakijalta edellytetään soveltuvaa AMK tai yliopistotutkintoa tai vastaavaa koulutusta. Hakijalta edellytetään osaamista ja työkokemusta projektikoordinaatiosta sekä ICT-taitoja. Eduksi katsotaan aikaisempi kokemus laboratoriossa työskentelystä, signaalinkäsittelytaidot ja tiedonhallintataidot. Tehtävän menestyksellistä hoitamista edesauttavat hyvä englannin kielen taito, kyky sekä itsenäiseen työskentelyyn että tiimityöhön ja analyyttinen sekä kriittinen oman työn arviointi ja kehittäminen.

Laboratoriomestarin tehtäväkohtainen palkanosa määräytyy yliopistojen palkkausjärjestelmän muun henkilöstön tehtävien vaativuustason 6 (2 092,99 €/kk) perusteella. Lisäksi maksetaan henkilökohtaiseen työstä suoriutumiseen perustuvaa palkanosaa 6-50 % tehtäväkohtaisesta palkanosasta.

Tehtävää täytettäessä käytetään kuuden kuukauden koeaikaa.

Lisätietoja:   apulaisprofessori Neil Cronin, neil.j.cronin@jyu.fi, puh.+358408053735.

Sähköiseen hakulomakkeeseen tulee liittää:

1) Hakemus
2) Ansioluettelo (cv)
3) Muu liite, jolla hakija haluaa osoittaa kelpoisuutensa ja ansionsa tehtävään.

Hakemus tulee jättää viimeistään 6.6.2019 sähköisellä hakulomakkeella.

Biomarker scientist – Charles River, Kuopio

https://jobs.criver.com/job/Kuopio-Biomarker-Scientist-IS-70210/561750400/?fbclid=IwAR2IkZmDakFrPjQYju0wBoDyHbpJ1gMfU7962YmiQmpw1NN-U3oALq8Ohqk

Biomarker Scientist

Req ID #:  44673 Location: 

Kuopio, IS, FI, 70210

For over 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Scientist, Neuroimmunology and immunohistochemistry

We are looking for a scientist with proven track of experience in ex vivo molecular and cellular neuroscience.

The position requires expertise in immunology and immunohistochemistry in basic science and preferably drug discovery using preclinical models of CNS.

In this position you will be independently leading projects focusing to relevant ex vivo endpoints of efficacy in animal models, including e.g. PD, AD, MS and injury-triggered animal models.

You have a strong expertise in various types of ex vivo analysis and interpretation of biomarkers derived from preclinical in vivo models. You have strong background e.g. in multiparameter flow cytometry, immunohistochemistry, cytokine profiling, supporting immune function assessment.

You are independently able to manage planning, coordination, supervision and execution of the ex vivo part of client projects and ensuring the scientific excellence including data analysis and reporting of the results. Scientist will be working closely with other teams and clients. In addition to client projects, scientist will be involved R&D activities including validations of new markers and assays to support ex vivo readouts.

Qualifications and Experience:

• Higher education degree in biological science (MSc) with 3+ years of experience, preferably PhD degree
• Pharmaceutical industry, Preclinical Contract Research Organization or academic post-doctoral experience will be an asset.
• Good problem solving skills, ability to coordinate and prioritize
• Scientific expertise with demonstrable understanding of ex vivo techniques and neuroimmunology as a component in CNS diseases
• Understanding of key features of in vivo pharmacology studies and drug development process in neurology and psychiatry
• Hands on experience in development, optimization and validation of immunohistochemistry targets in CNS tissues
• Hands on experience in development, optimization and validation of multi-color flow cytometry, data analysis and troubleshooting using multiparametric data analysis
• Experience in other immunological techniques like in vitro cell cultures, Luminex, ELISA, gene expression analysis (qPCR, QuantiGene Plex) will be an asset
• Fluent oral and written English, excellent communication skills, interpersonal and teamwork abilities
• Ability to mentor and train staff will be an asset

About Discovery

Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 11,000 employees within 70 facilities in 18 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges.  Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2016, revenue increased by 23.3% to $1.68 billion from $1.36 billion in 2015.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~70% of the drugs approved by the FDA in 2016.

For more information, please visit www.criver.com.

Job Segment: Chemistry, Scientific, Biotech, Scientist, Telecom, Science, Engineering, Technology

PhD project in inflammation and infections group at the Haartman Institute, University of Helsinki

PhD project in inflammation and infections group

PhD project is available in the research group led by Dr. Karita Haapasalo at the Department of Bacteriology and Immunology, Haartman Institute. We are looking for an ambitious and enthusiastic MSc of MD with a research interest in immunology and inflammatory diseases. The project is suitable for a applicant with a knowledge of immunology, microbiology, biochemistry, cell biology or other relevant field. After a four months trial period there is an opportunity to continue the project and apply for PhD studentship.

To apply, please send a CV including course evaluation records and Master’s diploma, a short cover letter explaining motivation to scientific research and names and contact details of at least two referees as one single document to karita.haapasalo@helsinki.fi. Applications will be accepted until the position is filled. 

See more information here: https://www.helsinki.fi/en/researchgroups/inflammation-and-infections

Postdoctoral position(s) available with a strong background in cell biology/mitochondrial biology at the University of Helsinki

Postdoctoral position(s) available in autumn 2019 at the University of Helsinki

Our lab studies mitochondrial morphogenesis and dynamics. More specifically, we focus on the molecular mechanism of mitochondrial membrane architectural organization and factors involved in regulation of mitochondrial shape, dynamics, and their functional link to mitochondrial diseases.

We are looking for highly motivated individual(s) with a strong background in cell biology/mitochondrial biology, and biochemistry.

For more information, please refer to the relevant publication:

Wang L, Yan Z, Vihinen H, Eriksson O, Wang W, Soliymani R, Lu Y, Xue Y, Jokitalo E, Li J, Zhao H* (2018) FAM92A1 Is a BAR Domain Protein Required for Mitochondrial Ultrastructure and Function. J. Cell Biol. 218:97-111.

Please send a cover letter with short description of your research interests and previous experience, current CV, and names of three references to Hongxia.zhao@helsinki.fi .