26.9.2016 | Ajankohtaista
Zora Biosciences Oy is a discovery diagnostics company. Zora identifies, validates and develops novel clinical tools using a specialized biomarker discovery platform based on mass spectrometry driven lipidomics. Zora’s first marketed product is a test for the assessment of Cardiovascular risk. Zora is based in Espoo, Finland.
Zora is now providing an opportunity for a Bioinformatician
The job consists of statistical work and bioinformatics work for both customer as well as R&D projects. Additionally, support for development of company’s bioinformatic infrastructure, application of existing data processing methods and development of algorithms for data integration may be additional tasks. You must be dynamic, independent, and responsible team worker to succeed in this position. Fluency in written and oral English is essential.
Qualifications:
– Degree (MSc) in bioinformatics, or biochemistry with good knowledge of bioinformatics.
– Alternatively, degree in statistics with experience or interest in biological/medical research.
– Knowledge of SAS, R or similar.
– Experience with one or more of the following is an advantage: mass spectrometry data processing, development of algorithms for QC and raw data processing, clinical databases, statistical modeling techniques, analysis of omics data, programming.
We are offering a position in a challenging, high-pace and international working environment. We provide you the possibility to grow with the company, fostering your professional development.
Please send your CV and a cover letter describing your career perspectives, strengths and experience, in particular focusing on the items listed above to Head of Bioinformatics: Dr. Mika Hilvo: mika.hilvo@zora.fi; (tel: +358 50 534 7782).
Please submit the application by October 2nd, 2016.
26.9.2016 | Ajankohtaista
Dear all,
We are recruiting new personnel for our flagship project on neuromolecular and functional basis of human emotions at Turku PET Centre. Please see the links and job listing below. I would be grateful if you could pass these to anyone you think might be interested in working on affective neuroscience with us in Finland!
Open positions @ Uni Turku:
Direct links to job adverts:
All the best
Lauri
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Dr Lauri Nummenmaa
Associate professor in modelling and medical image processing
Turku PET Centre and Department of Psychology
University of Turku
FI-20014, Turku, Finland
26.9.2016 | Ajankohtaista
26.9.2016 | Ajankohtaista
We recently discovered a gene that explains 40% of the variation in age (and size) at maturity in Atlantic salmon (Barson et al. 2015). The gene, VGLL3, is a transcription co-factor that negatively regulates adipocyte differentiation in mice, and has been linked to pubertal timing in humans, but nothing is known about its role in regulating puberty in salmon. This post-doc will play a major role in designing and performing the experiments needed to fill this knowledge gap.
The post-doc will be responsible for conducting and co-supervising research within the project using various genomic, cellular and physiological approaches, e.g. expression profile characterization (both RNA and protein levels), ChIPseq, as well as functional validation (e.g. using CRISPR/Cas9) of candidate genes for life history traits such as age at maturity (Barson et al. 2015). Spending longer periods at collaborator labs in Norway may also be required. Experimental design and interpretation of results will be coordinated with a second postdoc project with an evolutionary and ecological focus that is being advertised simultaneously.
Suitable applicants will have a strong background in functional genomics and molecular biology in any species as demonstrated by publications in relevant fields. Experience with methodologies such as qPCR and CRISPR technologies, in-situ hybridization, immunohistochemistry and other relevant methodologies is an advantage, as is knowledge of bioinformatics, a demonstrated interest in evolutionary genomics and/or experience with fish husbandry.
Informal inquiries should be directed to Prof. Craig Primmer (craig.primmer@utu.fi). Formal applications should include a CV (with names and contact details of at least two referees), a publication list and a max. 2 page letter of motivation and can be uploaded at http://www.utu.fi/en/university/university-as-an-employer/open-vacancies/Pages/home.aspx. The deadline for applications is October 9, with the preferred starting date being January 2017. The position is available until the end of 2019 with a further 2 year extension possible. The starting salary is »3155 – 3500 EUR per month, depending on the previous relevant research experience of the candidate.
Barson et al. (2015) Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon. Nature 528:405–408.
See also
Aykanat T et al. 2015. Low but significant genetic differentiation underlies biologically meaningful phenotypic divergence in a large Atlantic salmon population. Molecular Ecology 24, 5158–5174
Johnston et al. 2014. Genome-wide SNP analysis reveals a genetic basis for sea-age variation in a wild population of Atlantic salmon (Salmo salar). Molecular Ecology 23:3452–3468.
26.9.2016 | Ajankohtaista
INVITATION FOR APPLICATIONS
The Institute for Molecular Medicine Finland (FIMM, http://www.fimm.fi ), part of the University of Helsinki and the Nordic EMBL Partnership for Molecular Medicine, is an international research institute in Helsinki focusing on human genomics and personalized medicine. FIMM integrates molecular medicine research, technology center and biobanking infrastructures ”under one roof” and thereby promotes translational research and adoption of personalized medicine in health care
FIMM is currently seeking outstanding candidates for the position of
Postdoctoral researcher in single cell processing
from 1 November 2016 to 31 October 2018 or upon agreement
Applications are invited for a post doc position in the FIMM Technology Centre (FIMM TC). FIMM TC has state-of-the-art infrastructures for genomics, medical bioinformatics, metabolomics, high-throughput screening, biobanking, biomarker discovery and other translational research platforms. FIMM Technology Centre has started to build up functionalities for single cell capture and processing to provide single cell services for the national research community in Finland.
The primary role of the postdoctoral researcher will be establishment and development of single cell processing infrastructure and setting up single cell analysis services in close collaboration with FIMM TC NGS team and local research groups. We offer a productive and extremely collaborative work environment and excellent technical research facilities.
A successful candidate is expected to have a doctoral degree in a suitable field (biochemistry, molecular biology or other relevant field). Experience in cell culture, FACS –and nucleic acid processing techniques is required and excellent organizing and project management skills are highly valued. The candidate should be capable to work independently as well as cooperate harmoniously with other members of the team. The candidate should also be fluent in English and able to communicate efficiently in an interdisciplinary environment.
A two year contract is initially available for the position starting on 1.11.2016 (negotiable), with a possibility for extension pending on successful review. The salary will be commensurate with qualifications based on the Finnish university salary (YPJ) system.
Application should be written in English and include a one page cover letter summarizing the applicant’s skills/interest, a CV with list of publications, contact information for two referees and transcript of university studies. The application, together with the required attachment, must be submitted through the University of Helsinki electronic recruitment system by clicking on Apply for job:
Not later than 30th September 2016.
26.9.2016 | Ajankohtaista
Post-doctoral position is available in the laboratory of Docent Kristiina Mäkinen at the Department of Food and Environmental Sciences, University of Helsinki, Finland. This ambitious project requires a postdoctoral scientist who is highly motivated to investigate challenging questions related to the recruitment of potyviral RNA from replication to translation. Deadline for applications is October 31, 2016.
Dr. Kristiina Mäkinen
University lecturer
Department of Food and Environmental Sciences
P.O.Box 56
00014 University of Helsinki
Finland
26.9.2016 | Ajankohtaista
Post-doctoral researcher position is available in the laboratory of Professor Jukka Westermarck at the Centre for Biotechnology, University of Turku, Turku, Finland.
We are looking for highly motivated researcher with PhD degree to join our dynamic research group broadly focused on understanding the regulation and function of tumor suppressor Protein Phosphatase 2A (PP2A) in human cancers.
Deadline for applications is the 5th of October, 2016.
26.9.2016 | Ajankohtaista
Post-doctoral position is available in the laboratory of Professor Jukka Westermarck at the Centre for Biotechnology, University of Turku, Turku, Finland. We are looking for highly motivated researcher with PhD degree to join our dynamic research group broadly focused on very exciting therapeutic potential of PP2A reactivation in cancer therapy (http://www.btk.fi/research/research-groups/westermarck/ ).
The project is focused on characterization of novel therapeutic opportunities emerging from our recently published and currently on-going research related to the role of PP2A in breast cancer development and drug resistance (Laine et al., unpublished, Laine et al., Cancer Disc., 2013, Niemelä et al., Oncogene, 2012, Come et al. Clin. Cancer Res., 2009). Recent very rapidly accumulating data from others and us indicate that targeting of PP2A inhibition mechanisms may open entirely new perspectives for treatment of cancer patients with otherwise dismal prognosis.
Candidate requirements:
· PhD or MD/PhD
· Highly motivated person with strong interest in translational cancer research
· Strong experience in basic and translational cancer research demonstrated by at least one first author publication in a relevant journal
· Experience using mouse tumor models is highly desirable
· Good skills in both oral and written English and in team-working are highly valued
Our selected recent publications:
Myant et al., Cell Reports, 2015
Ventela et al., Oncotarget, 2015
Kauko et al., Scientific Reports, 2015
Laine et al., Cancer Discovery, 2013
Khanna et al., Cancer Research, 2013
For further information or inquiries regarding this post, please contact Jukka Westermarck by e-mail: jukwes@utu.fi
The DL for applications is September 30, 2016 and position is available starting from October 15, 2016 or later. Position is initially for two years with a possibility to extension depending on the progress of the project. Position starts with 4 months trial period. To apply, e-mail to tiina.arsiola@utu.fi a single merged PDF document including your CV, list of publications and an application letter clearly describing how your profile matches to candidate requirements listed above, and other previous achievements in the field. Also include names and contact information of three references in the same PDF document. In the subject line of your e-mail, indicate the following text: Post-doc position/Breast cancer
26.9.2016 | Ajankohtaista
The University of Eastern Finland, UEF, is one of the largest multidisciplinary universities in Finland. In international rankings, we are ranked among the leading 300 universities in the world. The Faculty of Health Sciences operates at the Kuopio Campus of the UEF. The Faculty offers education in medicine, dentistry and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognized research activities are closely linked to the strategic research areas of the University. There are approximately 2,500 degree students and about 450 PhD students in the Faculty. The number of staff adds up to almost 700 experts (http://www.uef.fi/en/uef/ttdk).
The A.I. Virtanen Institute for Molecular Sciences at the Faculty of Health Sciences, UEF, is a research institute with the profile on molecular medicine of major diseases of high importance for health care. These diseases include cardiovascular diseases, neurodegenerative diseases, and metabolism-related diseases.
We are now inviting applications for an Early Stage Researcher (Neuroinflammation in Alzheimer’s disease) position, Faculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences, Kuopio Campus
We are looking for an enthusiastic PhD student candidate to work in the Neuroinflammation research group (http://www.uef.fi/en/web/aivi/tarja-malm-group) in the Academy of Finland funded project “Regulation of neuroinflammation via non-coding RNAs in Alzheimer’s disease”. The project aims at identifying the gene regulatory processes that take place specifically in microglia in healthy brain and during AD development. The PhD student will be working with next generation sequencing approaches, flow cytometric techniques and novel models of neuroinflammation including both in vitro and in vivo work. In addition, the candidate will be guiding other students working within the project and is expected to write scientific publications. An ideal candidate has suitable education, high motivation towards research career, excellent English skills, is capable of carrying out very precise laboratory work, has ability to work in a team, ability to take responsibility and initiative and has good knowledge in some of the following areas: cell culture techniques, animal work, molecular biology, flow cytometry and confocal / multiphoton imaging. The applicant needs to have recommendation from two previous and recent supervisors / PIs.
A person to be appointed as an early stage researcher shall be qualified to pursue postgraduate studies, i.e. he or she is required to have completed a suitable higher university degree. Positions of early stage researchers shall always be filled for a fixed term (UEF Administrative Regulations, Section 30).
The position is filled for a fixed term from 9.1.2017 to 31.12.2019 (with a possibility of extension after this period). The salary of the position is determined in accordance with the salary system of Finnish universities and is based on levels 2-4 of the job requirement level chart for teaching and research staff (€1,985.85 – 2,475.31/ month). In addition to the job requirement component, the salary includes a personal performance component, which may be a maximum of 46.3% of the job requirement component.
For further information on the position, please contact: Associate Professor, Academy Research Fellow Tarja Malm, +358 40 3552209, tarja.malm@uef.fi. For further information on the application procedure, please contact Human Resources Secretary Hanne Tanskanen, hanne.tanskanen@uef.fi.
A probationary period is applied to all new members of the staff.
The electronic application should contain the following appendices:
The application needs to be submitted no later than 10.10.2016 (by 24.00 hours Finnish time) by using the electronic application form.
19.6.2016 | Ajankohtaista
Pääkirjoitus, 03.05.2016
Solubiologi-lehti on uudistanut ulkoasunsa ja julkaisee tästä lähtien etukannessa solubiologiaan liittyvää värikästä ja inspiroivaa kuvantamista. Jos teiltä lukijoilta löytyy kaunista kuvamateriaalia, jonka haluaisitte koko Solubiologilukijakunnan nähtäville, niin ottakaa ihmeessä yhteyttä lehden päätoimittajaan tai aluetoimittajiin.
Tässä numerossa olemme ajan hermoilla Juha “Lihastohtori” Hulmin ja Heikki Kainulaisen artikkelilla, jossa kohtaa liikuntafysiologia sekä solu- ja molekyylibiologia. Syöpäosiossa Barun Pradhan sekä Liisa Kauppi kertovat meille DNA:n uudelleenjärjestelyjen havaitsemisesta syövässä, ja Kati Porkka selvittää meille miten infektio voi laukaista leukemian. Sanna Mäkelä puolestaa kertoo meille influenssaviruksen havaitsemisesta soluissa, ja numeron päättää meidän oman Solubiologit ry:mme puheenjohtajan tiivistelmä tämän vuoden työelä- mäseminaarista.
Lääketieteellisen tutkimuksen rehellisyys on ollut tapetilla tämän vuoden alussa Ruotsin kuuluisimmassa yliopistossa eli Karoliinisessa Instituutissa professorina työskennelleen Paolo Macchiarinin jäätyä kiinni tutkimusvilpistä. Tämä aikaisemmin regeneratiivisen lääketieteen edelläkävijänä pidetty lääkäri, joka ensimmäisenä maailmassa suoritti keinotekoisten kurkunpäiden implantaatioita, on tutkimuksissaan rikkonut eettisiä säännöksiä, tarpeettomasti vaarantanut potilaiden henkiä sekä vääristänyt tutkimustuloksia julkaisuissa.
Macchiarinin kaksi ensimmäistä operaatiota, joissa käytettiin elinluovuttajilta saatuja henkitorvia, olivat onnistuneita, ja nämä potilaat ovat edelleen hengissä ja hyvinvoivia. Kuusi sitä seuraavaa potilaasta, jotka saivat synteettisistä “scaffoldeista” ja potilaiden omista kantasoluista koostuvia kurkunpäitä – toimenpide, jota ei ollut vielä tieteellisesti todistettu toimivaksi – eivät selvinneet hengissä pitkään jatkuvista komplikaatioista johtuen. Macchiarini myös vääristeli potilaiden toipumista operaatioiden jälkeen hyvinkin korkean luokan julkaisuissa. Tapaus Macchiarini esimerkillistää tieteessä esiintyvän vilpin, joka pahimmillaan torpedoi koko tieteen perustan, ja joka voi asettaa potilaita hengenvaaraan sovelletussa tieteessä.
Aurinkoista kesää toivottaen!
Sebastian Landor
Artikkeli 1. Solu- ja molekyylibiologia liikuntafysiologien työkaluina, Juha Hulmi (PhD, dosentti) ja Heikki Kainulainen (Prof.)
Fysiologia on haastava tieteenala. Se yhdistää molekyylitason mekanismit, solujen vä- lisen kommunikaation, ja eri kudosten sekä koko kehon toiminnan tutkimuksen. Fysiologian osa-alue, liikuntafysiologia, on yksi Jyväskylän yliopiston liikuntatieteellisen tiedekunnan pääaineista. Se tutkii erityisesti liikunnan, ja uudempana ilmiönä myös liikkumattomuuden vaikutuksia elimistöön. Liikuntafysiologia pitää sisällään myös elimistön toiminnan ja suorituskykyyn vaikututtavien sairauksien tutkimuksen.
Artikkeli 2. Detecting DNA rearrangements- a focused approach, Barun Pradhan (M.Sc.), Liisa Kauppi (Assistant Professor, PhD)
Artikkeli 3. Infektio voi laukaista leukemian, Kati Porkka (FT)
Infektioiden on jo kauan uskottu liittyvän lasten leukemioihin. Vaikka tilastolliset tutkimukset ovat tukeneet tätä teoriaa, niin biologisia todisteita infektioille altistumisesta leukemioiden laukaisevana tekijänä ei ole ollut. Arvostetun Cancer Discovery –lehden joulukuussa 2015 julkaisemassa tutkimuksessa tämä yhteys vihdoin osoitettiin käyttä- mällä mallieläiminä hiiriä, joilla oli akuutille B-soluleukemialle altistava Pax5-geenin mutaatio. Jos hiiriä pidettiin olosuhteissa, joissa ne eivät altistuneet taudinaiheuttajille, niille ei kehittynyt leukemiaa. Jos ne sen sijaan siirrettiin pian syntymän jälkeen ympäristöön, jossa ne kohtasivat patogeenejä, 22% hiiristä sairastui leukemiaan. Tällä osoitettiin todeksi ns. viivästyneen infektion hypoteesi, jota on ensimmäisen kerran esitetty leukemian laukaisevaksi tekijäksi jo vuonna 1988.
Artikkeli 4. Influenssaviruksen tunnistus soluissa luontaisen immuniteetin reseptoreilla, Sanna Mäkelä (FM väit.)
Influenssainfektioita esiintyy Suomessa talvikaudella vuosittaisina epidemioina. Ajoittain influenssavirusinfektioita ilmaantuu myös laajempana pandemiana jos uudentyyppinen influenssavirus alkaa levitä ihmisestä toiseen. Viimeisin pandemian aiheuttaja oli ns. sikainfluenssavirus vuonna 2009, eli tyypin H1N1 pandeeminen influenssa A -virus. Influenssavirukset aiheuttavat ihmisissä hengitystieinfektioita, jotka voivat johtaa vakavaan tautiin perussairailla, immuunipuutteisilla tai iäkkäillä henkilöillä. Yleensä ihmisen immuunipuolustuksen tehokas aktivoituminen influenssavirusinfektion seurauksena johtaa taudin paranemiseen. Taudinaiheuttajan nopea tunnistus on edellytys immuunipuolustuksen tehokkaalle ja tarkoituksenmukaiselle käynnistymiselle. Soluilla on lukuisia erilaisia hahmontunnistusreseptoreiksi kutsuttuja reseptoreita, joiden avulla ne valvovat mikrobirakenteiden esiintymistä soluvälitilassa, solulimassa ja muissa solun rakenteissa. Havaitessaan mikrobirakenteen solut erittävät vasteena viestiaineita, eli sytokiineja, jotka ohjaavat immuunipuolustuksen toimintaa. Erittäin tärkeä puolustuskeino influenssavirusta vastaan on interferoneiksi kutsuttujen sytokiinien tuotanto, mikä puolestaan johtaa monien virusta rajoittavien soluproteiinien tuottoon. Tässä artikkelissa tarkastellaan influenssavirusinfektion aikaisia vaiheita soluissa, miten viruksen tunkeutuminen soluun havaitaan ja miten interferonivaste solussa laukeaa.
http://www.fennokauppa.fi/yrityksille/tuotteet/Laboratoriotuotteet
