Our international multidisciplinary research group (https://www.btk.fi/research/molecular-systems-immunology/)
led by Academy Professor Riitta Lahesmaa is based at Turku Centre for
Biotechnology (the Centre), BioCity Turku, Turku, Finland. We are
seeking for a motivated postdoctoral researcher or project researcher
with possibility to continue work as a doctoral candidate.
Disorders
in immune system and lymphocyte function lead to inflammatory diseases
e.g. rheumatoid arthritis and Type
1 Diabetes. Project will focus on studying the molecular mechanisms
underlying immune mediated diseases aiming at enabling individualized
treatment in the future.
Description of recruiting organization
Molecular
Systems Immunology group aims at understanding the regulation of human
immune system to predict, prevent
and treat immune mediated disorders. We study epigenetic and
transcriptional regulation of T cells and molecular mechanisms of immune
mediated diseases.
Turku
Centre for Biotechnology is a joint research institute of University of
Turku and Åbo Akademi University.
The mission of the Centre is to promote high quality research and
training. The Centre has excellent state-of-the-art technology platforms
and expertise in single-cell omics, next-generation sequencing,
epigenomics, proteomics, computational biology and high-end
cell imaging.
Project
The
project aims at understanding how novel regulators of immune system,
recently discovered by our group,
act on a molecular level. We will use cutting-edge single-cell omics
tools, i.e. single cell sequencing and mass cytometry. We will
collaborate closely with Dr. Tapio Lönnberg, an in-depth expert in
single-cell omics and head of our Centre’s single-cell omics
facility. Our key collaborator is Research Director Laura Elo and her
group, the Medical Bioinformatics Centre, who have developed novel tools
to analyses single-cell omics data.
Qualifications, successful candidates have:
A relevant doctor’s degree (postdoctoral researcher) or a relevant master’s degree (project researcher) e.g. in
life sciences or in biomedicine
High level of motivation, self-initiative and independency
Excellent team work and communication skills in English (both oral and written)
First-rate molecular and cell biology knowledge and skills
Strong publication record in international journals (postdoctoral researcher) at least in one of the following areas:
immunology, molecular and cellular biology, autoimmunity, genetics, epigenetics.
Application
The
salary is in accordance with the University salary system (for teaching
and research personnel) level 5 (postdoctoral
researcher) where the work specific salary component is 2 903,61 €/month
or levels 3-4 (project researcher), where the work specific salary
component is 2 209,17 – 2507,62 €/month. In addition, there is a share
increase based on the personal performance,
which is, at most, 50% of the base salary. The position starts at
earliest on March 1st, 2019 (or as agreed). The positions are initially
for two years, one optional year possible. There is a trial period of
six months.
Please include a CV, full publication list, list of selected publications and contact information for three references
in your application.
For further information on the positions please contact: Prof. Riitta Lahesmaa, e-mail: riitta.lahesmaa@btk.fi
. Enquiries on the application procedure may be directed to Human Resources Specialist Paula Luoma, paula.luoma@utu.fi .
Kuopio Center
for Gene and Cell Therapy (KCT) is a world-renowned research institute
located in Kuopio, Finland. Our mission is to conduct high-level
research on basic and translational fields of gene- and cell therapy.
The centre’s niche is in the interface between academic, basic research
and the commercial biotechnology industry. KCT provides an exciting
environment for applied research, discovering, establishing and
developing them through Phase I clinical trials and utilizing some of
the most advanced analytical and mechanistic proof-of-principle
approaches in the sector.
Now we are
seeking for an efficient manager to coordinate our in vivo studies to
support the development of investigational gene- and cell therapies. The
successful candidate will be responsible for designing, implementing
and overseeing of animal studies including pathology, histology and
molecular analytics. The candidate must have a strong in vivo
pharmacology experience. This person will work closely together with
internal project teams and external collaborators and therefore have
excellent communication skills.
Main responsibilities
Design and manage in vivo experiments for gene- and cell therapy pharmacodynamics, pharmacokinetic and efficacy studies.
Follow the field of experimental animal science and applicable technologies
Work in close collaboration with research teams and animal facility personnel.
Analyze data, interpret results and design subsequent studies.
Present and document research plans, results and apply for necessary project licenses and authorizations.
Requirements:
MSc with several years’ experience or PhD from applicable field
Strong experience with in vivo animal experimental models
Excellent oral and written communication skills in English
Must be able to multitask and collaborate in multidisciplinary environment
Strong motivation, flexibility and ability to troubleshoot
We
offer young and dynamic working environment. Possibility for career
development in a growing international research center. Be part of our
future success!
More information Cell Therapy Unit Director Tuija Kekarainen tel. 040-5376603, phone calls 15th Jan at 12-14 (Tuija.kekarainen@kct.fi) and HR Director Johanna Pirinen (Johanna.pirinen@kct.fi).
The Neuroscience (NS) Department at Novartis Institutes for Biomedical Research (NIBR) in Basel, Switzerland, is seeking a Scientist with Molecular and Cell Biology skills to join a lab focusing on neuroscience. The specific focus of the team is to modulate neuroinflammation to ameliorate or halt pathology in neurodegenerative diseases.
As part of a multidisciplinary, highly collaborative team, you will independently plan, execute and analyse experiments and interpret data aiming at the discovery of new therapeutic targets and drug leads. The group is using complex primary cell culture models, but also establishing cellular high and medium throughput assays to assess therapeutic efficacy of antisense oligonucleotides, antibodies or low molecular weight compounds under relevant physiological conditions. On top of a solid neurobiological background, good knowledge of and experience with immunological methods would be an asset.
You will present data in meetings within the department and contribute to writing of research documents and publications. Furthermore, you will interact with multiple groups within our department as well as with other groups and external colleagues and have the opportunity to represent the lab in project team meetings.
Minimum Requirements
Master’s degree in Molecular Biology, Biochemistry, Biotechnology or another relevant Life Science discipline
Several years of post-graduate experience in industry or academia in drug discovery or related laboratory research
Proficiency in Molecular and Cell Biology techniques, comprising but
not restricted to cultivation and manipulation of cell lines and primary
cell cultures, biochemical assays (e.g. recombinant DNA technologies,
cytokine assays, second messenger assays, ELISA, signaling assays,
western blot) and high content cellular imaging technologies
Excellent understanding of pathway biology and experience in solving drug discovery related biological questions
Proven experience with complex cellular models, in particular with ES
cells and or iPS cells and confocal microscopy is advantageous
Highly motivated team player with refined collaboration skills
Excellent communication and interpersonal skills
Fluency in English (oral/written)
Division NIBR Business Unit NEUROSCIENCE Country Switzerland Work Location Basel
Company/Legal Entity
Novartis Pharma AG Functional Area Research & Development Job Type Full Time Employment Type Regular
Would you like to participate in scientific
innovation that makes a difference in patients’ lives? And do you have
cell culture experience?
Then join AGC Biologics as a Scientist in Upstream
Process Development and become part of an international and modern
organization that delivers biopharmaceutical development and
manufacturing. We get it right. On time.
The Department The Upstream Process Development group is responsible for cell
line development, cell culture process development, fermentation process
development, process characterization and upstream process and
technology transfers. Projects range from early pre-clinical development
through all phases of clinical development all the way to commercial
supply. Upstream Development is also responsible for all cGMP cell
banking activities, design of platform processes and evaluation and
implementation of new upstream technologies and techniques.
The work environment in our department is very informal. There is
constant collaboration across the entire organization, and all employees
have a very professional and flexible attitude towards their work.
Responsibilities and tasks
As a Scientist you will be involved in multiple upstream development
projects, and participate in multi-disciplinary project teams including
upstream, downstream and analytical scientists working in close
collaboration with the clients’ scientific teams.
The upstream process development team is covering both microbial and a
mammalian cell culture projects. Depending on the future needs and your
experience and skills, you will be involved in working with cell line
development, cell culture process development, optimization and
manufacturing support. The process development is performed in scales
from a few mL up to 100L. Development, evaluation and scale up of new
process methodologies in the development laboratory are some of the
responsibilities of the team.
The job includes:
planning and coordination of activities and experiments
verbal and written reporting to clients
strategic technology development
technical guidance within development and manufacturing
technical advice to business development
Experience and competencies Ideally you hold a PhD in Molecular Biology, Cell Biology, Biochemistry or Biochemical Engineering. In addition, you have:
a minimum of 5 years of relevant experience from the industry
demonstrated strong expertise within developing upstream processes
thorough understanding of how modifications in cell culture conditions affect the quality and functional activity of proteins
experience in handling bioreactors; fed-batch and/or continuous cultivations
good interpersonal and communication skills
ability to handle several projects simultaneously
experience in planning, performing and reporting experiments
fluency in English, written and spoken
AGC offers AGC offers a dynamic working place with good opportunities of
working with a varied array of tasks and challenges. You will get
insight into and experience with the way the various departments
throughout a contract manufacturing organization interact in order to
achieve success. Exciting and challenging assignments will constantly
come your way, and you will to a large extent be able to plan your daily
work yourself. AGC offers an informal working environment, where humor
is part of the daily work life. We respect each other and our individual
differences. AGC’s employees have a flexible attitude and we help each
other to reach deadlines together as one team.
For
further information regarding the position please contact Lena Nielsen,
Director of Upstream Development, lnielsen@agcbio.com.
We
will process the applications as they arrive. Therefore, please submit
your application and CV as soon as possible and no later than January
15, 2019.
PhD student positionfor 4 years is available in the research group led by professor Annamari Ranki to study targeted
treatment of autoimmune disorders. The full-time position will start immediately.
Our group is funded by
the Academy of Finland, Cancer Foundation Finland and Helsinki
University Hospital Research Funds. We are part of the Medical Faculty’s
Translational Immunology Research Programme as well
as participate in multiple collaborations within and outside of
Finland.
We are seeking
dedicated and enthusiastic candidates with a Master’s degree in
cell/molecular biology, developmental
biology, bioengineering, biomedicine,
or other appropriate field. The applicant should have practical experience of standard cell biology techniques. Previous experience
in molecular biology and gene expression analysis is considered an advantage. We also expect good communication skills (both Finnish
and English) and ability to interact efficiently in a team.
Our overall goal is to define and develop a curative cell-based treatment for the severe multi-organ genetic disease autoimmune-polyendocrinopathy-candidiasis-
ectodermal dystrophy. APECED is caused by loss-of-function
mutations in the AIRE gene which is the master regulator of immune
tolerance, operating both in the thymus and in peripheral lymphoid
organs. We currently work with iPSCs derived from
APECED patients, correct the mutated gene by lentiviral introduction
and in collaboration with international partners aim
to redifferentiate the gene-corrected cells to the phenotypes that
normally express AIRE. The efficiency and engrafting potential of
the gene-corrected cells
will be tested in vivo in animal models.
We will offer a competitive salary based on previous qualifications, experience
and personal performance in the position according to University pay-scale. A six-month trial period will be applied.
We use a
wide range of molecular, cellular, and imaging techniques and thus
offer a multidisciplinary, international and inspiring research
environment with access to state-of-the art technologies.
The deadline for submitting applications is January 28th,
2019, but review of applications will begin immediately and continue until the position is filled.
A postdoctoral position is currently available in Leslie Sombers’ Lab at NCSU (https://www.somberslab.org/)
on projects related to monitoring endogenous opioid neuropeptides in live brain tissue using fast-scan cyclic voltammetry, microdialysis, and HPLC-MS.
The
project(s) will integrate multidisciplinary approaches including
electrochemistry, optogenetic and chemogenetic manipulation, and
behavioral analyses.
A
postdoctoral position in neuroscience is available immediately at the
Virginia Commonwealth University (VCU) School of Medicine in the
laboratory of Kurt F. Hauser. The
candidate will study fundamental mechanisms underlying glial dysfunction
and synaptodendritic injury in the striatum and hippocampus following
opioid and HIV exposure.
The
candidate will have the opportunity to integrate basic cellular and
molecular approaches aimed at elucidating how opioid abuse exacerbates
glial dysfunction and synaptodendritic
injury in neuro-acquired immunodeficiency syndrome (neuroAIDS). The
candidate will join a team that utilizes multi-disciplinary cell
signaling, pharmacological, immunological, neurophysiological (including
optogenetics), and behavioral strategies to explore
opioid-HIV interactions in murine (in vitro and in vivo) and human (in
vitro) models. Cutting-edge imaging facilities, which include
structured illumination and multiphoton microscopy are available. A
Ph.D., M.D. and/or equivalent doctoral degree with experience
in cellular and molecular neuroscience or neuropharmacology is
essential. Additional experience in neurophysiology and/or optical
physiology (genetically-encoded voltage and calcium indicators) is
highly desirable. The candidate will be provided with significant
training in those disciplines with which they are less familiar, as well
as significant mentoring to facilitate their transition to an
independent research career.
Interested
individuals are encouraged to forward a curriculum vitae, a list of
three references, and a statement of research interests and career goals
to Kurt F. Hauser,
Department of Pharmacology & Toxicology, Institute for Drug &
Alcohol Studies, VCU School of Medicine, Molecular Medicine Research
Building, 1220 E. Broad St., Richmond, VA 23298 (email: kurt.hauser@vcuhealth.org).
We
are looking for a postdoc or project researcher in Biostatistics as
part of our multidisciplinary and international team of experts in the
Computational Biomedicine group
at the Medical Bioinformatics Centre, Turku Centre for Biotechnology.
The applications should be submitted at the latest on 4.2.2019 using the electronic system.
The application should include a motivation letter,
CV, list of publications, contact information for 3 referees, and copies
of relevant degree certificates. A link to the electronic application
system can be found at https://www.utu.fi/en/university/come-work-with-us/open-vacancies
ID 6697.
The
Hohmann laboratory in the Department of Psychological and Brain
Sciences and Gill Center for Biomolecular Science at Indiana University
is seeking
multiple postdoctoral research fellows to work at the interface between
drug addiction and chronic pain. We are investigating the impact of
cannabinoids, including functionally biased cannabinoid CB2 agonists, on
opioid reward using drug self-administration,
in vivo voltammetry and conditioned place preference. The impact of the
same treatments on opioid-induced respiratory depression is also
assessed using whole body plethysmography. The Hohmann laboratory is
funded by the National Institute on Drug Abuse, the
National Cancer Institute, the Indiana Clinical Translational Sciences
Institute and, most recently, by Indiana’s Addiction Grand Challenge
Initiative.
Qualified
candidates should have a Ph.D. in neuroscience, pharmacology,
biological psychology or related fields. Experience with drug
self-administration
and/or in vivo voltammetry is strongly encouraged. The successful
candidate should be interested in combining pathological pain models and
classic approaches from drug abuse. The laboratory is highly
collaborative with other outstanding neuroscience laboratories
at Indiana University. The Hohmann laboratory consists of a dynamic
group of postdoctoral fellows, graduate students, undergraduate
researchers and a laboratory technician.
Interested candidates should forward their CVs and names of three references to:
Andrea G. Hohmann, Ph.D.
Linda and Jack Gill Chair of Neuroscience and Professor
The
Institute for Molecular Medicine Finland (FIMM) is an international
research institute focusing on human genomics and personalised medicine
at the Helsinki Institute of Life Science (HiLIFE)
of the University of Helsinki. FIMM integrates molecular medicine
research, technology centre and biobanking infrastructures under one
roof, promoting translational research in grand challenge projects,
specifically, the impact of genome information from the
Finnish population in personalised health and medicine, individualised
cancer medicine, and digital molecular medicine. FIMM is part of the
Nordic EMBL Partnership for Molecular Medicine, composed of the European
Molecular Biology Laboratory (EMBL) and the
centres for molecular medicine in Norway, Sweden and Denmark, and the
EU-LIFE Community.
FIMM is currently seeking two
BIOINFORMATICIANS
Job description:
FIMM
is the leading genetics and genomics research unit in Finland. We are
managing petabytes of human genetic and health data and these datasets
will increase tenfold in the forthcoming
years. We’re daily collaborating with top researchers and research
institutes in the world and international health-care companies to
improve health and well-being on a global scale.
We
are looking for bioinformaticians with experience on large scale
genetic analyses (e.g. GWAS, exome sequencing). The data-analyst would
be working in one of the largest genetic projects
in the world, FinnGen. Launched in 2017, FinnGen is a unique research
project that combines genomic information with healthcare data from
national registries in search of the next breakthroughs in disease
prevention, diagnosis and treatment. The aim is to get
500,000 Finns to participate in the study through donation of a sample
to a biobank. FinnGen brings together academic partners, the nation-wide
network of Finnish biobanks & nine pharmaceutical companies.
The candidate will work in
data-analysis team which has members both at FIMM and at Broad Institute
of Harvard who are working closely with each other. Candidate will
report to Dr. Mark Daly (Director of FIMM, one
of the most cited scientists in genetics https://hcr.clarivate.com
) and Dr. Mitja Kurki
(Analysis team leader). The successful candidate will join an
interdisciplinary team of computational biologists, computer scientists,
bioinformaticians, analysts, epidemiologists and
clinicians who will build the FinnGen dataset.
Responsibilities
of the bioinformatician include e.g. quality control of genetic data,
execution of genome-wide analysis of 1000’s phenotypes (pheWAS), result
visualization and reporting,
evaluation and troubleshooting of analyses (e.g. violation of
statistical assumptions, detecting batch effects) and evaluation and
application of published statistical methods for genetic analyses.
Successful candidate will also take part in automating e.g.
the pheWAS analyses via robust analysis pipelines and development of
result visualization browser.
Suitable
backgrounds are e.g. a degree in statistical genetics, bioinformatics,
statistics, computer science or other relevant quantitative field.
Essential
skills include command of any general-purpose programming language
(preferably Python), knowledge of applied statistic, good Linux/Unix
user skills (no administration skills
required), statistical programming in R, knowledge of commonly used
statistical genetic tools and willingness to learn more (e.g. Plink,
Hail, variant prediction tools) and experience in high performance
computing cluster.), knowledge of SQL/noSQL databases,
web development and cloud computing experience are an asset.
Successful
applicant does not need to be an expert in all listed skills and the
job will be tailored to match the skillset of successful applicant.
Don’t hesitate to contact us with inquiries
about the position and if your unique skillset would be a good fit for
the position!
The primary responsibilities of the position include (depending on qualifications of the applicant):
· Large scale genetic data-analysis
in high performance computing cluster and cloud environments
· Participating in development
and R&D for analysis pipelines automating large scale pheWAS
· Participate in development
of web-based visualization and reporting tools using open source tools
· Participate in R&D of tools
and pipelines for interpretation of pheWAS-results (e.g. finemapping, tissue specificity)
· Support research projects by
preparing and delivering analyses in a timely fashion
· Evaluate new methods and solutions
for data-analysis and visualization.
· Pre-processing and quality
control (QC) of sequencing variant (VCF) and chip data
Qualification and experience:
· Master’s/Bachelor’s
degree
(or soon graduating) in bioinformatics, computational biology, molecular
biology (with strong computational skills), computer sciences, or other
relevant quantitative field. Ph.D. is an asset.
· Capability to work effortlessly
in Linux/Unix environment, at least intermediate programming skills
· Previous
experience with handling
and analysis of GWAS and sequencing data, data science, software
engineering, web development, high performance computing environment
(e.g. Grid Engine/ IBM LSF) and cloud computing (preferably Google
Cloud) are highly valued – yet ability to learn new is essential
· Solution-seeking, proactive
and responsible way of working and keeping deadlines under pressure
· Proficiency in oral and written
English, our team is international
We
offer a great opportunity to be part of leading big data projects
working in the forefront of the new wave of big data application for
genome health in the field of genomics and building
solutions with a real positive impact on healthcare and well-being. We
are a dynamic, vibrant and highly motivated international team. Our
friendly, flexible, and supportive working culture make us a great place
to work.
Salary and contract:
We
will offer a competitive salary that will be based on previous
qualifications, experience and performance in the position according to
University pay-scale. The contract will be offered
for 1,5 years, and may be extended.
To apply for the position,
please send your motivation letter and CV, including list of
publications and contact information for two references, through the University
of Helsinki electronic recruitment system by clicking on the Apply
link. Internal applicants (i.e., current employees of the
University of Helsinki) please submit your applications through the SAP
HR portal. Please apply no later than 31st January 2019. The employment may begin as soon as possible or
as agreed.
