29.4.2019 | Avoimet työpaikat
The
University of Helsinki is an international scientific community of
40,000 students and researchers. It is one of the leading
multidisciplinary research universities in Europe and ranks among
the top 100 international universities in the world.
HOH
Helsinki One Health is a new network organization, led by the Faculty
of Veterinary Medicine and cooperated by four other faculties at the
University of Helsinki, to co-ordinate research actions
within the area of One Health. One Health is a globally emerging
concept recognizing that the health of humans and animals is
interconnected and that their populations share the essentials of life:
the genome, disease causing organisms, health, welfare, and
the environment. HOH Helsinki One Health involves different disciplines
and professions to work together to resolve emerging health problems
concerning human and animal populations worldwide. In addition to other
profiling actions, HOH Helsinki One Health
will host several tenure track professorships with their established
research environments in years 2018-2022. Please see:
https://www.helsinki.fi/en/one-health.
We invite applications for the position of an
ASSISTANT PROFESSOR / ASSOCIATE PROFESSOR / PROFESSOR IN EMERGING INFECTIOUS DISEASES
This
is a joint position between the Faculty of Medicine and the Faculty of
Veterinary Medicine. The research and teaching field of the
professorship is microbiology, infectious diseases and vaccines.
More information and application at
https://www.helsinki.fi/en/open-positions/assistant-professor-associate-professor-professor-in-emerging-infectious-diseases-hoh-helsinki-one-health
Deadline for applications is May 26, 2019.
9.4.2019 | Avoimet työpaikat
Introduction
Blueprint Genetics is
on a mission to bring world-class genetic knowledge to mainstream
healthcare. To meet the challenges imposed by our rapid growth, we are
looking for new Geneticists to join our Clinical
Interpretation Team. We are a team of experienced professionals with
diverse backgrounds who share the passion for helping patients and
families suffering from inherited disorders. Our constantly evolving
diagnostic portfolio currently includes over 200 tests
that cover a wide variety of clinical specialties and diagnostic
approaches, including Whole Exome Sequencing. We work with hundreds of
clinics around the globe and the quality of our interpretation has been
praised by many of the world’s best medical centers.
If you have the ambition to be among the pioneers of the molecular era
of medicine, you might be the person we are looking for.
Job description
The position involves
interpretation and reporting of findings from our clinical molecular
genetic tests, including panel-based tests, Whole Exome Sequencing and
targeted variant tests. Our Geneticists also
participate in the development and validation of products and
applications in a project team environment. Those interested get to
collaborate with our Software Engineers and Data Scientists with the
development of our proprietary software tools that enable
us to interpret identified variants efficiently by utilizing artificial
intelligence and machine learning.
The ideal candidate has:
- Clinical
Laboratory Geneticist degree or Board certification in Clinical
Molecular Genetics / Laboratory Genetics and Genomics or Ph.D. in
Genetics.
- Experience
in interpreting and reporting genetic test results in a clinical
setting utilizing NGS, Sanger sequencing and other methods is an asset,
but similar research experience is valued as well.
- Knowledge of current genomic information and variant databases is essential
- Fluent skills in oral and written English are a necessity
- Great attention to detail
- Critical thinking when reviewing scientific literature
- Effective planning and organization skills
- Excellent follow-through abilities
- Experience in working under certified and accredited quality management systems is an asset.
- Fitting the immediate, low-hierarchy and positive Blueprint culture
What we offer
At Blueprint Genetics,
you get to be a valued part of our global and multidisciplinary team of
people who want to make a difference. You will be working daily to
bring your expertise from base pairs to bedside
for improved patient outcomes. We offer you a rapidly evolving working
environment where you can learn and grow together with a unique company
and great colleagues. You get to use everything you have learned in an
environment that is unlike anything you have
experienced before.
The position is permanent full-time position.
More information and application at https://careers.blueprintgenetics.com/jobs/212558-geneticist
9.4.2019 | Avoimet työpaikat
The
Faculty of Medicine promotes scientific research of a high standard and
is responsible for providing research-based undergraduate and
postgraduate education in medicine, dentistry, psychology and
logopedics, as well as for the English-language Master’s Programme in
Translational Medicine. In addition to its teaching and research
activities, the Faculty serves as a significant expert organisation in
the healthcare sector and contributes to the discourse
on ethics in the field. In terms of research, the Faculty aims for a
place among the best medical faculties in the world, while consolidating
and strengthening its status as a top-level institution of medical
education.
Together
with the Helsinki University Hospital (HUS) and the Helsinki Institute
of Life Sciences (HiLIFE), the Faculty of Medicine, University of
Helsinki, constitutes the Academic Medical Center Helsinki
(AMCH). This medical center has been very successful in international
comparisons, ranking among the top 10 medical campuses in Europe and
among the top 50 globally.
Research
Programs Unit of the Faculty of Medicine is a top-quality research
environment. Unit’s nine research programs comprises groups that
integrate clinical, translational and biomedical research.
Research
programs unit has an open position for a BIOINFORMATICIAN in an
exciting collaboration discovering pathways and targets for
neurodegenerative diseases. We search for an experienced
bioinformatician
highly motivated to participate in an early-discovery NeurOmics project,
belonging to a novel pharma-academia “New Modalities Ecosystem”.
More information and application at https://www.helsinki.fi/en/open-positions/bioinformatician
8.4.2019 | Avoimet työpaikat
Post-doctoral
job is available at the Research Centre for Integrative Physiology and
Pharmacology, In Docent Jukka Kero´s Thyroid
group at the Institute of Biomedicine, University of Turku, Finland. The
Department is well equipped with facilities for modern molecular and
cell biology research. The close connection with Turku Center for
Disease Modeling (TCDM) offers excellent facilities
and infrastructure to perform experiments with genetically modified
disease models.
We
are looking for a highly motivated senior researcher or a postdoc with
strong experience in molecular biology, genetics and experimental
disease models. The group focuses on molecular mechanisms of thyroid
disorders. We are studying thyroid genetics in patients with congenital
or hereditary thyroid diseases using in silico, in vitro methods, or
genetically modified disease models.
The research project focuses on novel gene mutations and testing their pathogenicity in vitro and in vivo.
The work
involves analyzing the next-generation sequencing data and generation
and phenotyping of new disease models. The researcher will work closely
with technicians and PhD-students in the group.
There is a trial period of four (4) months. The position is for 2-4 years and could start in May 2019 or as negotiated.
For more information, please contact Jukka.Kero@utu.fi
.
5.4.2019 | Avoimet työpaikat
We
have an opening for an enthusiastic post-doctoral fellow to study the
molecular mechanisms governing actin polymerization, ATP
hydrolysis, phosphate release, and filament stability in malaria
parasite actins. The successful candidate has a keen interest to
understand cytoskeletal proteins and cell motility in depth. A strong
background in protein biochemistry and X-ray crystallography
is required. Expertise in cryo-EM sample preparation and structure
determination will be highly valued. In addition, a high level of own
initiative and the ability to work in a team and supervise younger
scientists are necessary.
The Faculty of Biochemistry and Molecular Medicine (FBMM; https://www.oulu.fi/fbmm/)
is a dynamic and international working place, where the working language
is English. Protein science is one of the focal areas of the Faculty.
FBMM provides cutting-edge research facilities for molecular biology,
protein biochemistry, X-ray crystallography,
and light and electron microscopy. In addition, we have generous access
to several large-scale facilities for structural biology
(MX/SAXS/cryo-EM).
Funding
is initially available for 2.5 years, but there may be possibilities
for an extension. The starting date should be as soon
as possible.
Applications and informal enquiries should be sent by e-mail to inari.kursula@oulu.fi.
Applications should contain
(i) a cover letter detailing your specific
interest in this project and your key skills and expertise,
(ii) a CV including a list of publications,
and
(iii) contact information (e-mail) for
3 referees.
Applications should preferably be sent by 30.4.2019, but screening of
candidates will continue until a suitable one has been identified.
For more information on our work, please visit our website: http://cc.oulu.fi/~inkursul/lab
Some recent publications directly relevant for the topic:
Kumpula
EP, Lopez AJ, Tajedin L, Han H & Kursula I (2018) Atomic view into
Plasmodium actin polymerization, ATP hydrolysis, and
phosphate release. bioRxiv: 467423, https://doi.org/10.1101/467423.
Kumpula
EP, Pires IP, Lasiwa D, Piirainen H, Bergmann U, Vahokoski J &
Kursula I (2017) Apicomplexan actin polymerization depends
on nucleation. Sci Rep 7: 12137.
Pospich
S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I & Raunser S
(2017) Near-atomic structure of jasplakinolide-stabilized
malaria parasite F-actin reveals the structural basis of filament
instability. Proc Natl Acad Sci 114: 10636-10641.
Green
JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J,
Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP,
Moon RW, Molloy JE, Kursula I, Tewari R & Holder AA (2017)
Compositional and expression analyses of the glideosome during the
Plasmodium life cycle reveal an additional myosin light chain required
for maximum motility. J Biol Chem 292: 17857-17875.
For a full list of publications from our group, see: http://cc.oulu.fi/~inkursul/lab/Molecular_mechanisms_of_actin-based_motility/publications.html
3.4.2019 | Avoimet työpaikat
Postdoctoral position in skin appendage development and regeneration – Departments of Genetics and Dermatology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA USA
The
Kamberov lab is seeking a candidate to fill a post-doctoral position in
skin appendage development and regeneration. The relevant project will
focus on investigating
the signaling networks that control mammary and sweat gland development,
functionality and evolutionary variation. A major goal of this project
is to regenerate these organs in vitro. Experimental approaches to be
used include generation, analysis and validation
of large-scale transcriptomic data from the skin, functional testing and
modeling in mice and in vitro organoid culture. The position provides
an exciting opportunity to work at the interface of basic and
translational research in a highly collaborative environment
and gain experience in approaches at the cutting edge of developmental
and regenerative biology.
Interested
applicants should send a CV, contact information of three references
and a letter detailing your interest in the position and lab to Yana
Kamberov (yana2@pennmedicine.upenn.edu).
Applicants should hold a Ph.D. in biology or related field. Applicants
with a strong background in molecular biology, mouse genetics,
developmental biology and/or bioinformatics are encouraged to apply.
https://www.kamberovlab.com/
3.4.2019 | Avoimet työpaikat
The
University of Eastern Finland, Faculty of Health Sciences, A.I.
Virtanen Institute of Molecular Sciences, invites applications
for a Postdoctoral Researcher (Bioinformatics / Neurosciences).
The
Kanninen research group is seeking a motivated and experienced
postdoctoral researcher to join a highly dynamic group of
neuroscientists working on Alzheimer’s disease. The group utilizes
in vitro cultures of brain cells to investigate molecular and cellular
mechanisms of neurodegeneration. More details on research interests can
be found at https://www.uef.fi/en/web/aivi/katja-kanninen-group
In
this position the candidate should have a PhD in computer science,
bioinformatics, biostatistics, neuroscience or related discipline.
Experience with various statistical methods is required
and the successful candidate should be proficient in using the R
programming language. The candidate should be committed and motivated,
display independent thinking skills, and possess the ability to work
independently while supervising students. Good knowledge
of written and spoken English are essential.
The
application deadline is 16/04/2019 and the position is filled for a
fixed term from 1st of May in 2019 (or as agreed) to 30th of April in
2020. The position is filled for a fixed term
due to the duration of the project. More details at https://www.uef.fi/en/web/guest/uef/en-open-positions
For further information on the position, please contact: Group Leader, PhD, Associate Professor (tenure track), Academy Researcher
Katja Kanninen, +358 29 4454202,katja.kanninen@uef.fi.
For further information on the application procedure, please contact HR Secretary Asta Suhonen, tel. +358 29 4454125, asta.suhonen@uef.fi.
2.4.2019 | Avoimet työpaikat
The
Faculty of Medicine promotes scientific research of a high standard and
is responsible for providing research-based undergraduate and
postgraduate education
in medicine, dentistry, psychology and logopedics, as well as for the
English-language Master’s Programme in Translational Medicine. In
addition to its teaching and research activities, the Faculty serves as a
significant expert organisation in the healthcare
sector and contributes to the discourse on ethics in the field. In
terms of research, the Faculty aims for a place among the best medical
faculties in the world, while consolidating and strengthening its status
as a top-level institution of medical education.
Together
with the Helsinki University Hospital (HUS) and the Helsinki Institute
of Life Sciences (HiLIFE), the Faculty of Medicine, University of
Helsinki,
constitutes the Academic Medical Center Helsinki (AMCH). This medical
center has been very successful in international comparisons, ranking
among the top 10 medical campuses in Europe and among the top 50
globally.
Research
Programs Unit
of the Faculty of Medicine is a top-quality research environment.
Unit’s nine research programs comprises groups that integrate clinical,
translational
and biomedical research.
Cancer Cell Biology group led by Professor Päivi Ojala (https://www.helsinki.fi/en/researchgroups/cancer-cell-biology)
at the Translational Cancer Medicine Research Program (CAN-PRO),
Faculty of Medicine, University of Helsinki, is seeking outstanding
candidates for
POSTDOCTORAL RESEARCHER
The open positions are in the fields of cancer cell biology and/or virus-host interactions in a project funded by Academy
of Finland.
Our research is
focused
to study the role of lymphatic endothelium in the tumor
microenvironment and cancer metastasis. We are interested in the changes
in the tumorigenic properties of the
cancer cells upon contact with the lymphatic endothelium, (Pekkonen et
al, eLife 2018; PMID:29712618) and also in the changes induced in the
lymphatics by the tumor cells. In the virus-host interaction studies we
are using Kaposi sarcoma herpesvirus (KSHV),
an oncogenic human gamma-2 herpesvirus, as a model system to study
cancer development and progression (Gramolelli et al, Sci Rep 2018;
PMID:29934628).
Ultimately, our studies aim to provide
mechanistic insights into both improving existing clinical regimens and
in identifying novels targets for therapeutic intervention.
We
are looking for highly motivated post-doctoral fellows who have
successfully completed a PhD
in a field relevant to the molecular and cellular biology of cancer
and/or virology and published at least one peer-reviewed article in a
Pubmed-indexed journal. Experience in mammalian cell culture, cell and
molecular biology, as well as microscopy techniques
are required. Candidates with demonstrated skills and prior experience
in the analysis of NGS datasets and/or mouse tumor models as well as
proven track record in terms of publications will be given preference.
Initial contract of employment will be done until the end of 2020 and
starting as soon as possible.
The contract of employment includes a probationary period of 6 months.
Salary will be based on the Universities
salary scheme for teaching and research personnel composed of both task
specific and personal performance components.
The application should be
in form of a single-pdf containing a one-page cover letter
describing your areas of expertise and motivation for the
position, recent CV with a publication list, and names and contact
information of two to three references.
The
application, together with the required attachments, must be submitted
through the University of Helsinki electronic recruitment
system by clicking on Apply for job. Internal applicants (i.e., current
employees of the University of Helsinki) must submit their applications
through the SAP HR portal.
Application at
https://www.helsinki.fi/fi/avoimet-tyopaikat/postdoctoral-researcher . Apply at latest 10.04.2019.
Further information is available from Professor Päivi Ojala:
paivi.ojala(at)helsinki.fi.
2.4.2019 | Avoimet työpaikat
The
University of Helsinki is an international scientific community of
40,000 students and researchers, and ranks among the top 100
international universities in
the world.
Research Programs Unit (RPU) of the Faculty of Medicine, University of Helsinki (https://www.helsinki.fi/en/faculty-of-medicine/research-programs-unit)
consolidates demonstrated research excellence, with nine focused
research programs combining clinical, translational and biomedical
research.
The
group of Associate Professor Pipsa Saharinen works on the molecular and
cellular mechanisms that regulate blood vessel functions during
inflammation and in cancer (www.helsinki.fi/saharinenlab).
A special focus is on the dynamic regulation of vascular permeability
by angiopoietin
growth factor, cytokine and integrin adhesion receptor signalling. The
group is funded by the European Research Council (ERC) and belongs to
the Academy of Finland Centre of Excellence in Translational Cancer
Biology.
The Saharinen group is currently seeking for a
POSTDOCTORAL RESEARCHER
for a fixed-term starting as soon as possible, upon mutual agreement.
Highly
motivated individuals with a commitment to excellence and with the
capability to work independently and as a part of a dynamic
and collaborative research group are encouraged to apply. A PhD degree
in Life or Biomedical sciences, or an MD PhD degree, as well as
excellent communication skills in spoken and written English, are
required. Strong background in vascular/cancer biology,
imaging, mouse genetics, or cell/molecular biology is an advantage.
We
offer an international, inspiring and supportive research environment,
excellent research facilities with access to state-of-the art
technologies and a competitive salary, which is comprised of two
separate parts; the job requirement component (here, level 5) and the
personal performance component based on previous qualifications,
experience and personal work performance, as per defined
in the General Collective Agreement for Finnish Universities. A
six-month trial period will be applied.
The
application should include the following documents as a single
pdf-file: a cover letter describing previous achievements and motivation
for the position (1 page), CV, track record of peer-reviewed
publications, and names and contact details of two to three referees. To
apply, please, go to
https://www.helsinki.fi/en/open-positions/postdoctoral-researcher-position
Apply by 15.4.2019.
The position will be filled
once a suitable candidate has been identified. Further information is
available from Pipsa.Saharinen(a)Helsinki.fi, tel. +358-50-4486361.
Recent publications:
Hakanpaa et al., Targeting beta1-integrin inhibits vascular leakage in endotoxemia. Proc Natl Acad Sci USA. 115:E6467-E6476, 2018.
Korhonen E, Lampinen A et al.
Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest. 126: 3495-3510, 2016.
Hakanpaa et al. Endothelial destabilization by angiopoietin-2 via integrin β1 activation. Nature Commun 6: 5962, 2015.
Saharinen et al., Therapeutic targeting of the angiopoietin–TIE pathway. Nat. Rev. Drug. Disc. 16:635-661, 2017.
Eklund L, Kangas J, Saharinen P. Angiopoietin-Tie signaling in the cardiovascular and lymphatic systems. Clin. Science. 1:87-103,
2017.
30.3.2019 | Avoimet työpaikat
https://job-search.astrazeneca.com/job/gothenburg/phd-position-drug-disposition-and-kinetics-nanosims-imaging/7684/11340707
Location: Gothenburg, Västra Götaland County, Sweden Job reference: R-047805
Posted date: Mar. 27, 201
Are you interested in imaging
the inner structure of single cells to understand how drug molecules
reach their subcellular targets? Would you like to contribute to the
establishment of new technologies to study drug disposition/kinetics in
cells and tissues by doing your PhD at AstraZeneca, a company that is
following the science and turning ideas into life changing medicines?
Then you might be the one we are looking for!
AstraZeneca is now recruiting an Industrial PhD student to join theDrug Metabolism Pharmacokinetics (DMPK) New Modalities function within the Cardiovascular, Renal and Metabolism (CVRM) therapy area. CVRM is intensely pursing new drug modalities (e.g peptides, proteolysis targeting chimera “PROTACs”, RNA based therapeutics).
Building an understanding about subcellular trafficking presents a real
opportunity for the development of biopharmaceuticals where we will
design molecules that effectively navigate these pathways to reach their
targets. This PhD project will be done as part of the University of Gothenburg Chemical Imaging Infrastructure (CII)under
the direction of Andrew G. Ewing. The successful candidate will be
employed by AstraZeneca, and work collaboratively within the CII located
at the AZ BioVentureHub, Gothenburg, Sweden.
The PhD project
In
the pursuit of applying new drug modalities we are finding that
intracellular target engagement is of critical importance. Thus,
information concerning intracellular drug concentrations is greatly
needed. However, this information is difficult to obtain, and it has
been suggested that this space is one of the most neglected areas of
drug discovery. AstraZeneca, in association with the CII, has now begun
to integrate Nanoscale secondary ion mass spectrometry (NanoSIMS)
imaging into the suite of technologies to study drug
disposition/kinetics in cells and tissues.
This project is a Stiftelsen för Strategisk Forskning (SSF)
funded industrial PhD position with the aim of developing a single cell
analytical nano-imaging technique to provide subcellular drug
distribution imaging with high sensitivity. It aims to combine advanced
analytical technologies to solve fundamental biological questions of
intracellular drug trafficking, to study and quantify endosomal escape
and concentration of drug at disease targets inside the cell. You will
develop the ability to bridge the physical aspects of ion/matter
interactions and the biological process under investigation. In addition
to course work and basic training for the PhD, you will develop
scientific concepts and communicate the results of your research
verbally and in writing. The position includes teaching (laboratory or
tutorial) at the undergraduate level or performing other duties
corresponding up to 20 per cent of working hours. Your major
responsibilities will be to pursue your own doctoral studies.
About the CII
The
Chemical Imaging Infrastructure (CII) is a world-unique research
infrastructure with a primary focus on high lateral resolution imaging
mass spectrometry. Internationally CII has a world leading equipment
base backed up by internationally recognized experts in the development
and application of SIMS. CII is hosted by the Department of Chemistry
and Chemical Engineering at Chalmers and by the Department of Chemistry
and Molecular Biology at the University of Gothenburg.
Requirements
- To
qualify as a PhD student, you must hold a Master’s level degree in
BioScience, Biochemical Engineering, Biotechnology, Biochemistry,
Chemistry or a similar area.
- A strong interest in biology is
required and experience with cell culture an advantage. Experience with
mass spectrometry and image analysis is preferred but not required.
- Excellent English in writing and speaking and strong communication skills are required.
- Due
to the multi-disciplinary nature of this PhD project, you should
preferably be curious, goal oriented, cooperation minded, and keen on
transferring theoretic and applied academic work into practice.
If you are interested, apply now!
For
more information please contact recruiting manager Michael Kurczy
michael.kurczy@astrazeneca.com or academic supervisor Andrew Ewing
andrew.ewing@gu.se
Welcome with your application no later than April 21, 2019.
AstraZeneca
is an equal opportunity employer. AstraZeneca will consider all
qualified applicants for employment without discrimination on grounds of
disability, sex or sexual orientation, pregnancy or maternity leave
status, race or national or ethnic origin, age, religion or belief,
gender identity or re-assignment, marital or civil partnership status,
protected veteran status (if applicable) or any other characteristic
protected by law.