28.12.2016 | Ajankohtaista
Two postdoctoral positions are immediately available within the Epigenetics Group at the International Agency for Research on Cancer (IARC), Lyon France, to study epigenetics and cancer. The Group conducts both epigenetic profiling and mechanistic studies, aiming to enhance our understanding of mechanisms of carcinogenesis and cancer etiology and to discover and validate new epigenetic biomarkers. It exploits new concepts in cancer epigenetics and recent technological advances in epigenomics.
1. Postdoctoral opportunity in epigenetic mechanisms and cancer development.
An important focus of the group is to investigate epigenetic mechanisms (DNA methylation and histone modifications) underlying cancer development and progression. This research line builds on the most recent knowledge of the cancer genome and epigenome, new concepts, and genomic databases. A postdoctoral opportunity is immediately available within the Group to apply state-ofthe-art molecular/cell biology and new functional genomic tools for mechanistic studies focusing on functionally important epigenetic “driver” genes (“epidrivers”) and associated molecular pathways. This also includes the development and application of in vitro models (for example, human and mouse immortalization models), new (epi)genome editing tools, and functional genomics. We also study interactions of epidrivers with selected known and suspected carcinogens (with focus on non-genotoxic “epigenetic” agents) that may play a role in tumour initiation and progression through epigenetic mechanisms. Candidates with a background in epigenetics, molecular biology,
and genome editing (such as CRISPR-Cas9 system) with a good command of English are encouraged to apply. Experience in, genome-wide shRNA screens and functional (epi)genomics would be an asset.
2. Postdoctoral opportunity in epigenetics and breast cancer.
Another focus of the group is to investigate how the epigenome (methylome) deregulation (epigenetic drift and/or methylation age acceleration) contributes to breast cancer development and to identify risk factors associated with these changes. We also aim to test whether breast cancer-specific methylome changes can be detected in circulating free DNA, and whether these epigenetic changes can serve as sensitive
biomarkers in prevention of breast cancer. Our approach includes cutting edge epigenomics, population-based cohorts, and innovative bioinformatics tools to investigate epigenomic profiles of cancer and surrogate tissues. Candidates with a solid background in epigenetics, molecular biology, and cancer research with a good command of English are encouraged to apply. Experience in molecular and epigenetic profiling (array- and/or Next-Generation Sequencingbased) and related data analysis and interpretation would be an asset.
Both postdoctoral opportunity is initially for one year with possibility of extension. The IARC stipend is currently €2750 per month. The cost of travel for the post-doc, and in certain circumstances for dependants, will be met, a dependant’s allowance paid, and health insurance covered. Official working language at IARC is English.
Applicants should send a CV, including list of publications and a description of previous research experience, as well as the names and addresses of two academic referees, preferably by email to: ege@iarc.fr
To the attention of: Dr Zdenko Herceg, Epigenetics Group, International Agency for Research on Cancer, 150, cours Albert Thomas, 69372 Lyon Cedex 08 France, Tel +33-472738398
27.12.2016 | Ajankohtaista
POST-DOCTORAL RESEARCHER AND DOCTORAL STUDENT POSITIONS
The open positions are in the fields of systems biology and translational cancer research in project funded by EU Horizon 2020 (HERCULES) and Academy of Finland (OVCURE). The goal of the HER-CULES project is to use cutting-edge single-cell measurement technologies and computational methods to identify drug resistant cell populations and develop combinatorial treatments to effectively kill drug resistant cancer cells. The goal of the OVCURE project is to develop and apply integrative computational methods to identify predictive models for treatment efficacy by taking an advantage of multi-level big omics data (e.g., transcriptomics, genomics, genetics, epigenetics, and proteomics jointly with clinical and functional information). Both projects are based on prospective ovarian cancer patient clinical samples taken before and after the treatment.
We are looking for an ambitious post-doctoral researcher and a doctoral student with strong enthusiasm towards science. A successful candidate has strong background in applied mathematics, machine learning, multivariate statistics, computer science, programming or bioinformatics. Basic understanding of cancer biology or genetics/genomics considered as an asset and ability to work together with medically/biologically oriented researchers is required.
Initial contract of employment will be done for minimum of two years and the starting date is to be agreed, preferably at spring 2017. Trial period of four months will be applied. Salary will be based on the Universities salary scheme for teaching and research personnel composed of both task specific and personal performance components.
We offer an international multidisciplinary research environment with state-of-the-art facilities. The re-search will be carried out in the Systems biology of drug resistance in cancer research group in collaboration with highly skilled groups with complementary expertise in biochemistry, molecular biology, high-throughput molecular technologies, mathematical and computational modelling, and clinics. The Systems Biology research group belongs to Research Programs Unit (RPU) of the Faculty of Medicine and operates at the Meilahti Campus, the Academic Medical Center Helsinki, where the close vicinity of the research laboratories with Helsinki University Hospital and Finnish Institute for Molecular Medicine sup-ports the integration of biomedical, translational, and clinical research.
To apply, please submit your application letter, CV, publication list and names of two references in a single PDF document through the university’s electronic recruitment system by February 1st, 2017:
Postdoc position:
Graduate student position:
For further information contact:
21.12.2016 | Ajankohtaista
1: Physiology and pathology of development and function of basal ganglia – towards understanding and treatment of neurologic diseases
The project:
The project aims at characterizing basic mechanisms of neurogenesis in developing and adult striatum with particular focus on retinoid receptor signaling. Relevance of obtained data for understanding etiology and physiopathology of neurologic disorders including in particular restless legs syndrome (RLS; one of the most frequent neurodevelopmental disorders) will be investigated using new genetic mouse model of disease. The project will be carried out at IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of dynamic research region at crossroads of France, Germany and Switzerland. It will benefit from such location and state-of-the-art infrastructure and expertise in developmental biology, animal behavior and pharmacology, genomics and bioinformatics. In addition, close collaboration with world leaders in clinical research in RLS and neurodegeneration will be mandatory to identify relevance of obtained data for the clinical condition and test new strategies of therapy.
The applicant:
We are looking for highly motivated post-doctoral fellow with solid research experience in molecular and cell biology, and biochemistry (experience in developmental neurobiology, primary mammalian cell cultures or life imaging will be a great asset). Experience in work with rodent models is encouraged. Candidate must have at least one first author publication. The ability to work in an English speaking team and good communication skills are required. The ideal candidate should be able to bring original input to the 2 1/2 year challenging project and participate in animating team’s life.
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2. mechanism of depressive behaviors
The project:
The global aim of the project is characterization of neuron-glia interactions in animal models of depression using electrophysiological approaches combined with histological and molecular analyses and behavioral, and pharmacological studies. The relevance of obtained data for research into treatment resistant depression will be tested using dedicated animal model and molecular analyses on human material obtained through collaborations with specialists in psychiatry and pharmacology. The project will be carried out at IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of dynamic research region at crossroads of France, Germany and Switzerland. The project will benefit from such location and state-of-the-art infrastructure and expertise in animal behavior and pharmacology, molecular, genomic and bioinformatics analyses.
The applicant:
We are looking for highly motivated post-doctoral fellow with solid research experience in electrophysiology (whole cell recordings). Any additional experience in histology, imaging, molecular or cell biology will be welcome. Experience in work with rodent models is encouraged. Candidate must have at least one first author publication. The ability to work in an English speaking team and good communication skills are required. The ideal candidate should be able to bring original input to the challenging project and participate in animating team’s life.
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3. A vitamin for neuroprotection
The project:
The project aims at characterizing mechanisms of neuroprotective activities of retinoid signaling. This multidisciplinary project emerging from close collaboration with chemists will include genomic analyses (RNAseq, ChIPseq, proteomics) combined with analyses of neuron-glia interactions, mitochondrial functions. Neuroprotective activities of selected candidate genes and new bioactive metabolites will be also tested. The relevance of obtained data for research into neurodegenerative diseases will be determined using dedicated animal models, human cells cultured in vitro and human material obtained through collaborations with specialists in neurology. The project will be carried out at IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of dynamic research region at crossroads of France, Germany and Switzerland. The project will benefit from such location and state-of-the-art infrastructure and expertise in animal behavior and pharmacology, molecular, genomic and bioinformatics analyses.
The applicant:
We are looking for highly motivated post-doctoral fellows who correspond to either of the following profiles: 1) solid research experience in biochemistry, mitochondrial biology and molecular biology or 2) solid research experience in genomic, bioinformatics analyses with an interest in extending his/her experience to developmental or molecular neurobiology. Experience with neural stem cells and primary neuronal cultures or studies of microglia cells are strongly encouraged. Candidate must have at least one first author publication. The ability to work in an English speaking team and good communication skills are required. The ideal candidate should be able to bring original input to the challenging project and participate in animating team’s life.
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Applicants should submit their complete application file (CV, motivation letter, publication list and contact to at least two reference scientists in one PDF file) by email.
Contact information:
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France
email: krezel@igbmc.fr
21.12.2016 | Ajankohtaista
The University of Eastern Finland, UEF, is one of the largest multidisciplinary universities in Finland. We offer education in nearly one hundred major subjects, and are home to approximately 15,000 students and 2,800 members of staff. We operate on three campuses in Joensuu, Kuopio and Savonlinna. In international rankings, we are ranked among the leading 300 universities in the world.
The Faculty of Health Sciences operates at the Kuopio Campus of the University of Eastern Finland. The Faculty offers education in medicine, dentistry and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognised research activities are closely linked to the strategic research areas of the University. There are approximately 2 500 degree students and about 450 PhD students in the Faculty. The number of staff adds up to almost 700 experts. http://www.uef.fi/en/ttdk/etusivu
We are now inviting applications for
a Postdoctoral Researcher position School of Pharmacy, Kuopio Campus
A person to be appointed as a postdoctoral researcher shall hold a suitable doctoral degree. Positions of postdoctoral researchers shall always be filled for a fixed term (UEF Administrative Regulations 30 §). The doctoral degree should be in cell biology, molecular biology, biochemistry, pharmacy, or an equivalent closely related field.
The doctoral degree may not have been completed more than five years ago at the time of accepting the position. In this context, the 5 years refer to a net period of time, which does not include maternity leaves, parental leaves, or military service, etc.
The language requirements associated with the position are defined in the Government Decree 770/2009. Members of the university’s teaching and research staff are required to have command of the language they give teaching in (Finnish or Swedish). The Dean of the faculty may grant an exemption from the language proficiency requirements laid down in the Government Decree.
The research group (http://www.uef.fi/eye/io) constitutes part of the emerging research areas identified in the strategy of the university. We are looking for an energetic and committed researcher to work on research projects focused on revealing mechanisms of age-related macular degeneration and developing new therapy options for the disease. The work will include determination of cellular responses and deciphering intracellular signalling.
We are primarily looking for a researcher with solid experience in cell laboratory work, capability of planning research projects, as well as ability to perform fluently basic protein chemistry and immunology methodology. An organised, independent, and problem-solving working attitude is expected, and the applicant should have an ambition for improving existing methodology. Our group offers a chance to work together with both basic researchers and clinicians in a truly translational setting.
The position will be filled initially for one year preferably from 1.4.2017 to 31.3.2018. Positions of postdoctoral researchers shall always be filled for a fixed term (UEF Administrative Regulations 30 §).
The salary of the position is determined in accordance with the salary system of Finnish universities and is based on level 5 of the job requirement level chart for teaching and research staff (€2.865.30/ month). In addition to the job requirement component, the salary includes a personal performance component, which may be a maximum of 46.3% of the job requirement component.
For further information on the position, please contact: Associate Professor, Academy Research Fellow Anu Kauppinen, anu.kauppinen@uef.fi. For further information on the application procedure, please contact Administrative Secretary Seija Koistinen, +358 -40 – 355 2440, Seija.Koistinen@uef.fi.
A probationary period is applied to all new members of the staff.
The electronic application should contain the following appendices:
- a résumé or CV
- a list of publications
- a portfolio of teaching merits
- copies of the applicant’s academic degree certificates/ diplomas, and copies of certificates / diplomas relating to the applicant’s language proficiency, if not indicated in the academic degree certificates/diplomas
- a cover letter describing the applicant’s motivation, future career plans, and previous achievements
- two recommendation letters
The application needs to be submitted no later than 31.1.2017 (by 24.00 hours Finnish time) by using the electronic application form: https://rekry.saima.fi/certiahome/aew.html?job_id=3145&jc=21
21.12.2016 | Ajankohtaista
Haemme kahta väitöskirjatutkijaa Immuno-oftalmologian tutkimusryhmään (http://www.uef.fi/eye/io) Itä- Suomen yliopiston Kuopion kampukselle. Tutkimusryhmä on osa yliopiston strategian mukaisia nousevia tutkimusaloja. Silmänpohjan ikärappeuman mekanismit ja uusien terapiakohteiden etsintä tarjoavat mielenkiintoisen tutkimusalueen, missä biolääketieteellistä perustutkimusta tekevät tutkijat työskentelevät yhteistyössä kliinikoiden ja lääkekehityksestä vastaavien tahojen kanssa. Työhön kuuluu solun toimintojen mittaamista ja solunsisäisen signaloinnin määritystä.
Hakijan tulee olla jatkokoulutuskelpoinen, ylemmän yliopistotutkinnon solu- tai molekyylibiologiasta, biokemiasta, farmasiasta tai vastaavalta alalta korkeintaan neljä vuotta sitten suorittanut, motivoitunut, sitoutunut sekä organisointi- ja ongelmanratkaisukykyinen. Hakijan hyväksi luetaan aiempi laboratoriotyöskentely erityisesti kokemus soluviljelystä sekä proteiinikemian ja immunologian määritysmenetelmistä.
Hakemukset tulee lähettää yhtenä PDF-dokumenttina osoitteeseen anu.kauppinen@uef.fi 31.1.2017 mennessä. Paikat täytetään alkuun yhdeksi vuodeksi. Hakemukseen tulee liittää 1) motivaatiokirje 2) CV 3) julkaisuluettelo 4) kaksi suosituskirjettä (vapaaehtoinen) Yhteydentotot: Apulaisprof., akatemiatutkija Anu Kauppinen, anu.kauppinen@uef.fi
16.12.2016 | Ajankohtaista
Description
Research in the Engin Lab, at University of Wisconsin-Madison, School of Medicine Department of Biomolecular Chemistry, is at the interface of endoplasmic reticulum stress, autoimmunity and immunology. We thrive to understand how stressed pancreatic beta cells and immune cells communicate during the progression of autoimmune diabetes, and how immunometabolic pathways and organelle homeostasis contribute to the autoimmunity. The highly interdisciplinary and collaborative environment of our group provides unique career development opportunities for the postdoc trainees. Please refer to our representative publications for details: Engin et al., Sci. Transl. Med. 2013, Engin et al., Sci. Rep. 2014.
Qualifications
• Recent Ph.D. with a strong background in the field of immunology and/or cell biology.
• Research experience in areas useful to studies of cell signaling, adaptive immunity, T cell biology, inflammation, and autoimmunity.
• Basic understanding of and experience with molecular biology and immunology related assays.
• Ability to work with mice.
• Ability to learn and develop new techniques, whenever necessary.
• Strong evidence of scientific accomplishment.
Job Duties
The candidate can either lead promising ongoing projects, or initiate and develop independent research projects within the broad realm of stress, immunology and diabetes. Candidate will receive active feedback and guidance in experimental planning, data presentation, manuscript writing, and development of grant proposals, as applicable. Additional responsibilities include: maintaining laboratory records, supervising students, and training laboratory staff in techniques and protocols.
Application
Candidates with outstanding oral and written communication skills, and strong relevant experience are encouraged to apply. Please send a cover letter with a short description of potential areas and projects, current CV, and three references to Dr. Feyza Engin (fengin@wisc.edu). A competitive stipend and excellent benefits will be provided for this position.
For more information, please visit our website: https://bmolchem.wisc.edu/engin.htm
https://www.researchgate.net/job/881092_Postdoc-Bioinformatics_Systems_Cardiology
16.12.2016 | Ajankohtaista
We are looking for a second postdoctoral researcher to join our team. The projects involve – apart from enthusiasm and dedication – the setup of novel methods and requires knowledge and experience in the areas of molecular biology (cloning, mutagenesis), E. coli genetics, protein analysis (Western, IP, ELISA), protein purification (basics) and cell culture (transfection, cell line establishment). Knowledge in bioinformatics will be advantageous. Project goals include improvements of in-vitro antibody generation technologies and the generation of antibodies. Details will be discussed in the job interview.
The postdoctoral position is for two years and will start during spring 2017 with a probation period. The salary is based on the standard University of Helsinki salary system. Applications are considered as soon as they arrive and there is no fixed closing date since before we can hire, we have to relocate our lab in-house to have more lab space, which will happen sometime during beginning of 2017.
How to apply?
If you are interested, please send your application including CV, motivation letter and names of two people who would be willing to provide references with contact information as a single pdf-document to michael@jeltsch.org with a notification ”MSc position”/”PhD position”/”Postdoc position” in the subject line of the mail. Please also attach or link to a short (maximally 2 minutes long) video, in which you explain, why you want to join our lab and why you are the candidate that we should chose. Please follow these instructions as I do not guarantee to answer applications that don’t fulfill these formal requirements.
For further information, see http://lab.jeltsch.org or contact Michael Jeltsch by e-mail (michael@jeltsch.org).
16.12.2016 | Ajankohtaista
A postdoctoral position is available in Dr. Z. Jim Wang’s laboratory at the University of Illinois medical campus in Chicago. A Ph.D. in a biomedical field is required. Experience with pain or opioid research is preferred, but not required. Our research focus is on molecular mechanism, epigenetics, and pharmacology of chronic pain and opioid pharmacology (see recent publications below).
To apply, please email curriculum vitae to:
Z. Jim Wang, PhD (zjwang@uic.edu)
Professor of Pharmacology
Department of Biopharmaceutical Sciences
Cancer Center, Sickle Cell Center, &
Program for Collaborative Research in the Pharmaceutical Sciences
University of Illinois, Chicago, IL 60607
(312) 355-1429
Some of our recent publications:
1.He Y, Wilkie DJ, Nazari J, Wang R, Messing RO, DeSimone J Molokie RJ, and Wang ZJ, PKCd-targeted intervention relieves chronic pain in a murine sickle cell disease model, J Clinical Investigation 2016, 126, 3053-7. PMID: 27348590.
2. He Y, Chen Y, Tian, X, Yang, C, Lu J, Xiao C, Desimone J, Wilkie DE, Molokie R, Wang ZJ, CaMKIIα underlies the spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice. Pain 2016, 157: 2798–2806. PMID: 27842048
3. Hu X, Huang F, Szymusiak M, Liu Y and Wang ZJ, PLGA-curcumin attenuates opioid-induced hyperalgesia and inhibits spinal inhibition of CaMKIIα, PoLS One, 2016; 11(1):e0146393. doi: 10.1371. PMID: 26744842
4. He Y, Wang ZJ, Nociceptor bII, d & e isoforms of PKC differentially mediate paclitaxel-induced spontaneous and evoked pain. J Neurosci 2015; 35(11):4614-25. PMID:25788678
5. Jhun E, He Y, Yao Y, Molokie RE, Wilkie DJ, Wang ZJ, Dopamine D3 receptor Ser9Gly and catechol-O-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease. Anesthesia & Analgesia 2014, 119(5):1201-7. PMID: 25102390
6. He Y, Yang C, Kirkmire CM, and Wang ZJ, Regulation of opioid tolerance by let-7 family microRNA targeting the μ opioid receptor. J Neurosci 2010;30(30):10251-8. PMID: 20668208.
2.12.2016 | Ajankohtaista
Position for a highly motivated and enthusiastic PhD student is available in virology / cell biology / biochemistry at the laboratory of Docent Tero Ahola, University of Helsinki, starting from January or February 2017 (or later by agreement). The group is part of the Department of Food and Environmental Sciences, Division of Microbiology and Biotechnology. The work is carried out under the supervision of Docent Maija Pietilä and Tero Ahola.
The student would take part in a research project studying formation, structure and function of viral replication complexes. This Academy of Finland- and University of Helsinki-funded project focuses on the replication of positive-strand RNA viruses. Such viruses have a major role in emerging and re-emerging epidemics, and new antiviral strategies are a necessity. All such viruses replicate their genome in membrane-associated complexes, and our aim is to understand how these complexes are formed and which cellular and viral factors are essential for their function in RNA synthesis. This information would help us to fight against infections caused by positive-strand RNA viruses.
The laboratory has long experience in studying the replication mechanisms of animal RNA viruses, using biochemical, virological and cell biological methods, including advanced fluorescence and electron microscopy. More information concerning the group is available at:
https://tuhat.halvi.helsinki.fi/portal/en/person/tahola
https://tuhat.halvi.helsinki.fi/portal/en/person/mpietila
For a successful applicant, previous experience with virus work is not necessary, but good knowledge and skills in biochemistry and cell biology are required. Especially, experience with RNA work and proteomics would be beneficial. We are seeking for motivated candidates able to work both independently and as a member of a team, with a strong interest in molecular biosciences, and willing to take initiative as well as capable of developing skills towards independent and creative scientific work. Fluent English communication skills (oral and written) are required.
The application should contain a cover letter stating applicant’s research interests and career motivation and curriculum vitae detailing the education and experience of the candidate, and the contact information of two references. Please compile all materials to a single PDF file. For more information on the advertised position, please contact Docent Maija Pietilä and send applications by email (maija.pietila@helsinki.fi). Interested students are encouraged to send their application latest by December 30th 2016.
Please contact:
Maija Pietilä, PhD, Docent in Virology
Academy of Finland Postdoctoral Research Fellow
Division of Microbiology and Biotechnology
Department of Food and Environmental Sciences
University of Helsinki
Viikinkaari 9, P.O. Box 56
00014 University of Helsinki
email: maija.pietila@helsinki.fi
phone: +358-504486393
2.12.2016 | Ajankohtaista
Are you looking for excellent research opportunities for your PhD studies at the forefront of basic, epidemiological or translational cancer research? At the German Cancer Research Center (DKFZ) in Heidelberg, Germany’s largest biomedical research institute, more than 500 PhD students unravel the causes of cancer development and develop novel tools for diagnosis, treatment and prevention.
PhD students are supported by a Thesis Advisory Committee, participate in scientific and professional skills courses, attend international conferences and receive career development support. The language of the PhD program is English. Full funding is provided for the duration of the PhD, either by the DKFZ, third party sources or in collaboration with the DAAD within their Graduate School Scholarship Program.
The DKFZ offers PhD projects in diverse and interdisciplinary cancer research topics:
• Cell Biology and Tumor Biology
• Functional and Structural Genomics
• Cancer Risk Factors and Prevention
• Tumor Immunology
• Imaging and Radiooncology
• Infection, Inflammation and Cancer
• Translational Cancer Research
Applications are invited from international students holding the equivalent of a university Master’s degree in the natural sciences. Research experience and
excellent English skills are a prerequisite.
Application deadline 5th January 2017.
