20.3.2022 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/2965197200
About the job
Would you be interested in working in diverse projects related to medical device / IVD regulatory affairs and compliance with evolving regulatory requirements? Are you passionate about working in the medical device industry and developing your expertise even further? If your answer is yes, you might just be the senior regulatory affairs expert we are looking for to join our team. Medfiles has offices in Finland and the Baltic countries, and you could be working in any of these countries.
What we expect from you:
- Relevant work experience in the regulated MD/IVD industry
- Demonstrated expertise in one or more areas related to compliance with EU regulation (MDR/IVDR), for example in product compliance or manufacturer and QMS requirements. Expertise in clinical/performance evaluation according to EU requirements is considered a clear advantage, and demonstrated ability to implement the requirements of the three inter-linked key processes of clinical/performance evaluation, risk management and post-market surveillance/post-market clinical follow-up, is highly appreciated.
- At least basic-level holistic understanding of EU regulation (MDR/IVDR) and applicable horizontal standards (such as ISO 13485 and ISO 14971). Experience in interpreting these requirements in various practical situations or knowledge of requirements in other key market areas, such as the USA or China, is considered an advantage.
- Demonstrated ability to write scientific documents. Experience in compiling technical documentation, various reports, protocols, SOPs and other similar documents in accordance with applicable requirements is highly appreciated.
- A suitable scientific or technical degree, preferably M.Sc.
- Active approach and high motivation to widen expertise in both medical device regulatory affairs and quality management
- Service- and solution-oriented mindset, flexibility to work in diverse projects
- Ability to work both independently and in a team with Medfiles’ other experts or our clients’ experts
- Fluent verbal and written English skills. Basic communication in Finnish is an advantage, but not a must
- Willingness to travel occasionally, also abroad.
As a senior regulatory affairs expert, you will be part of our Medical Devices Team offering comprehensive expert services to companies working with medical devices and IVDs, covering the entire product lifecycle. Additional information about our services can be found at https://www.medfiles.eu/services/regulatory/medical-devices-and-ivds/.
You will mainly work in our client projects as a senior expert in your area of expertise and also support and coach other team members in assignments related to your area of expertise. Furthermore, this position and working in our diverse client projects gives you the possibility to widen your expertise beyond your present know-how and qualifications. In addition to client projects, all team members participate in internal development activities and client marketing.
We offer an interesting and versatile expert position in our agile and inspiring, international work community. In addition to flexible working practices, such as the possibility to work from home, we support the well-being of our employees with a variety of employee benefits.
For more information about our company and the position, please contact Päivi Turta, Head of Operations, Medical Devices, on 17.3.2022 at 15.30-16.30, on 31.3.2022 and 12.4.2022 at 14.30–16.30 by phone, +358 50 3130 323, or by email paivi.turta@medfiles.eu.
Please send us your application and salary request in English by 15.4.2022. Don’t hesitate to apply already today – we review the applications as they come and will fill the position as soon as a suitable candidate is found.
20.3.2022 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/2958085169
About the job
The job:
We are looking for an ambitious Account Manager to join our Food Microbiology sales team. As Account Manager, you will sell our Microbiology portfolio to local accounts within the Food and Water testing segments, promoting the Microbiology value proposition to customers in advancing Food Microbiology through innovation.
You will develop a robust business plan for your territory, focussed on meeting or exceeding your sales targets through driving profitable growth. Our innovative product introductions planned for 2022 and beyond will deliver solution-based workflows to our customers and, as such, you will be responsible for developing an aligned strategy for the territory with vertical teams, functions and divisions in Thermo Fisher Scientific.
This is a field-based sales position with a territory covering all of Finland and Sweden. Regular travel on a weekly basis within your territory will be required – on average 3 to 4 days per week, with some overnight stays. When not travelling, you will be able to work from home. You must live in either Finland or Sweden, within commuting distance of an international airport.
Our Organisation
This role sits within our Microbiology Division (MBD) where we are focused on one thing: empowering the people who dedicate their lives to Microbiology. All of our customers deserve uncompromised quality and impeccable service, and they need a partner with the drive to accelerate innovation, enhance productivity and help shape the future. This is what we promise and what we strive to deliver. From the gold standard in culture media that laboratories have relied on for decades, to the game changing innovations of tomorrow, to supply chain optimization, we want to help laboratories work smarter, enabling microbiologists to focus on what truly matters – timely accurate diagnostics. When that happens outcomes improve, and our customers can make the world healthier cleaner and safer.
What will you do?
- Sell Thermo Fisher’s Microbiology portfolio to customers within the Food & Water testing segments, ensuring customers understand the Thermo Fisher Scientific value proposition
- Identify new business opportunities and new customers within your territory and support the channel (Fisher Scientific) to promote and sell Microbiology products
- Maintain and develop strategic relationships, enhancing business with national accounts to advance access and opportunities
- Implement preferred provider relationships and strategic partnerships to demonstrate the product portfolio
- Account Management Planning:
- Conduct analysis of industry trends and customer applications to assess the potential demands that clients may have within Pharma/Biotech space
- Develop short-, medium- and long-term strategies that result in improving the opportunities to increase the sales pipeline
- Lead contractual processes, including Confidentiality agreements, Preferred provider / Master Services agreements / pricing agreements and resolve commercial issues / negotiations
- Provide account status reports on a regular basis, working via Salesforce.com
Who we are looking for:
- Bachelor’s Degree in Microbiology, Molecular Biology, Biology, Biochemistry or similar
- Previous sales experience in any industry, although Life Science industry preferred
- We will also consider candidates without sales experience, but with strong lab-based experience looking to move into a sales role
- Fluent English and fluent in either Finnish or Swedish (essential)
- Valid driving licence
- Willing to travel within territory 3 to 4 days per week and lives within commuting distance of an international airport
What’s in it for you:
- Excellent career progression opportunities with a large and growing global employer
- Competitive salary, plus sales bonus, plus company car
- Full benefits package (specifics depend on country of hire)
About us:
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team of more than 100,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.
With Thermo Fisher Scientific, it’s not just a career. It’s a chance to realise your best – professionally and personally.
Apply today!
http://jobs.thermofisher.com
20.3.2022 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/2970504767
About the job
Are you motivated by using your data science skills to drive biological insights and are seeking a role where your expertise can make an extraordinary impact? This is an opportunity to join a dynamic and enthusiastic environment, whilst delivering critical support to drug discovery projects.
At AstraZeneca, we harness digital, data science & AI to fast-forward our research. Making sure the work born in a lab can make a real difference in the real world. Working here means thinking big, taking responsibility, and working together to deliver impact from our contributions that make the impossible a reality. Join a place built on innovation and creativity!
As we expand our operations within the data science domain, we are looking for a Quantitative Scientist to join our team at our vibrant AstraZeneca R&D site in Gothenburg, Sweden. This position is located within the Data Sciences & Quantitative Biology department – a global, diverse and delivery focused department where we collaborate to support drug projects striving to impact patients’ lives. In partnership with our experimentalist colleagues and other data scientists, we provide computational analysis and solutions to enable and improve output from our technical platforms driving our drug discovery efforts.
What you’ll do
You will work as part of a team passionate about improving our ability to validate drug targets in pre-clinical models of disease. You will work closely with a variety of colleagues with complementary skills and experience, both within and beyond our department, to improve the quality and impact of your work. In your role will focus on optimizing the way that we choose our pre-clinical models of disease to validate targets.
Being responsible for developing and internalising appropriate algorithms, techniques and datasets you will advance our ability to translate disease targets. You will also enhance our data analysis capabilities on complex, high-dimensional omics data to identify opportunities for target translation.
We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximise your potential and contribution, building from your current skills, abilities and experience.
Essential for the role
Our team is a highly collaborative group of scientists, working in a constantly evolving technical and scientific landscape. Therefore, you’ll have to be comfortable working at a fast pace, with a team-focused approach. You have excellent communication skills and a proactive, delivery-focused approach.
We believe you have a passion for driving scientific questions. The ability to receive and analyse input from multiple sources and based on this formulate a focused course of action. You have a consistent track record of delivering analytical solutions for business or academic needs. You can work independently and have a positive, result-oriented and problem-solving attitude.
- PhD – or equivalent numbers of years of experience post-degree – in bioinformatics, biological sciences, engineering, computational sciences or a related field
- General understanding of molecular biology, cell biology, and human physiology
- General knowledge of sequence-based bioinformatics
- Competency in a coding language such as R or python
Desirable for the role
- Comfortable working with high performance computing and cloud environments
- Good background in establishing data/information pipelines and applying best practice
- Familiarity with design of experiments
- Hands-on practice in omics analysis for example RNAseq
- Experience in delivering value in a dynamic, iteratively working team and via collaboration with other teams
- Experience in working with data sources relevant to drug development or biomedicine
- Experience with developing shiny apps or equivalent applications
Why AstraZeneca Gothenburg?
Our Gothenburg site is one of AstraZeneca’s three strategic R&D centres. Here, you’ll feel a global atmosphere in a multinational environment. Collaboration comes in all forms – across teams, functions, countries and even companies. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.
So, what’s next!
If your passion is science and you want to be part of a team that makes a bigger impact on patients’ lives, then there’s no better place to be.
We look forward to find out more about you. Send in your application as soon as possible, but no later than the 11th of April 2022. We will review applications continuously.
For more information about the role, the team or working for AstraZeneca, please contact the hiring manager Natalie Van Zuydam, https://www.linkedin.com/in/natalie-van-zuydam-03417625/.
Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
AstraZeneca R&D: https://www.astrazeneca.com/r-d.html
20.3.2022 | Avoimet työpaikat
https://duunitori.fi/tyopaikat/tyo/kesatoihin-kokoonpanoon-sartorius-kajaani-sssta-14608880?utm_source=loimu&utm_medium=email
Työtehtävän kuvaus
Etsitkö kesätöitä Kajaanin alueelta? Ovatko vahvuutesi sorminäppäryys, tarkkuus ja työmotivaatio? Kiinnostaako sinua merkityksellinen työ johtavassa terveysteknologiayrityksessä?
Etsimme Sartoriukselle Kajaaniin
KESÄTÖIHIN KOKOONPANIJOITA
pipettien valmistukseen. Kokoaikainen työsuhde sijoittuu välille 2.5.-31.8.2022 aikataulusi mukaisesti.
Tässä kesätyössä:
• Valmistat pipettejä ja niiden alikokoonpanoja
• Osallistut tuotteiden laadun valvontaan
• Työskentelet sekä itsenäisesti että osana tiimiä
Sinulla ei tarvitse olla työstä aikaisempaa kokemusta, sillä tehtäviin perehdytetään alusta alkaen. Tärkeintä tehtävässä on sorminäppäryytesi, tarkkuutesi sekä työmotivaatiosi.
Työ on kaksivuorotyötä ja viikossa töitä on 40h välillä ma-pe. Vuororytmin mukaisesti yksi viikko on aina samaa työvuoroa, jonka jälkeen vuoro vaihtuu. Aamuvuoro on 6-14 ja iltavuoro 14-22. Työaika kerryttää myös pekkasia.
Työsuhde sovitaan suoraan työntekijän ja Sartoriuksen välille.
Edellytämme sinulta
- Ahkeraa ja positiivista asennetta
- Tarkkuutta ja tunnollisuutta
- Valmiutta 2-vuorotyöhön
- Suomen kielitaitoa
Tarjoamme sinulle
- Kattavan perehdytyksen ja koulutuksen tehtävään
- Mukavat ja ammattitaitoiset työkaverit
- Laajan työterveyshuollon ja hyvät henkilöstöedut
- (mm. ePassin virike- ja lounasedun)
- Arvomme ”avoimuus, vastuullisuus ja ilo”, jotka näkyvät päivittäisessä arjessamme
- Vapaat viikonloput
Arvostamme
- Aikaisempaa kokemusta vastaavista tehtävistä
Hakuohjeet ja lisätiedot
Rekisteröidy hakijaksi kotisivuiltamme www.staffpoint.fi ja täytä hakemuksesi huolellisesti. Voit myös liittää CV:n hakemukseesi. Paikat täytetään heti sopivien henkilöiden löydyttyä, joten haethan pian!
Työsuhde sovitaan suoraan työntekijän ja Sartoriuksen välille ja rekrytointi toteutetaan yhteystyössä StaffPointin kanssa.
Vastaa kyselyyn
StaffPointilla lähtökohtana on, että jokaiselle hakijalle vastataan, sillä ymmärrämme työnhaun olevan aina henkilökohtaisesti hyvin merkittävää. Jokainen työnhakija on huomion arvoinen tarkoittaa lupausta etsiä parempia keinoja kohdata jokainen hakija. Näin luomme entistäkin yksilöidymmän hakijakokemuksen.
Nyt haluamme kehittää hakijakokemustamme vielä askeleen pidemmälle. Olit sitten työnhakija, -tekijä tai -antaja toivoisimme kuulevamme, mistä sinun mielestäsi huomioiva työnhakijakokemus syntyy.Vastaa kyselyyn täällä.
Kiitos vastauksestasi jo etukäteen!
20.3.2022 | Avoimet työpaikat
https://duunitori.fi/tyopaikat/tyo/orion-development-pharmacist-injection-team-sdsuu-14609038?utm_source=loimu&utm_medium=email
Työpaikkakuvaus
Etsimme injektiotiimiin asiantuntijaa Development Pharmacistin tehtävään Espooseen toistaiseksi voimassa olevaan työsuhteeseen.
Tehtävän kuvaus
Toimit farmaseuttisena asiantuntijana ja vastuullasi on markkinoilla jo olevien tuotteiden tuotehuoltoon, ylläpitoon ja kehittämiseen liittyviä tehtäviä. Vastuullasi voi olla mm. tuotteiden teollistaminen, koe-erien seuranta, tuotemuutosten toteuttaminen ja dokumentointi sekä myyntilupadokumentaation laatiminen. Toimit aktiivisessa yhteistyössä tuotannon, laadunvarmistuksen, laadunvalvonnan, tekniikan ja oman yksikkösi asiantuntijoiden kanssa. Työskentelet myös tiiviisti partnereiden kanssa ja tarvittaessa osallistut viranomais- ja partneritarkastuksiin yhdessä muiden asiantuntijoiden kanssa.
Yksikön kuvaus
Globaalien operaatioiden Commercial Product Development and Licecycle Management -organisaation vastuulla on huolehtia Orionin portfolioon sisältyvien tuotteiden tuotehuollosta, kilpailukyvystä ja jatkokehityksestä. Vastaamme myös lääkevalmisteiden teknologian siirrosta ja Orionin alkuperätuotteiden teollistamisesta sekä toimitusketjun projektiportfolioiden hallinnasta.
Tarjoamme
Tarjoamme sinulle monipuolisen ja vaihtelevan tehtäväkentän menestyvässä yrityksessä sekä mahdollisuudet ammatilliseen kehittymiseen. Tässä tehtävässä pääset perehtymään injektioihin tuotemuotona ja sen erityispiirteisiin. Tulet osaksi seitsemän henkilön asiantuntijatiimiä, jossa on hyvä yhteishenki sekä avuliaat työkaverit.
Meille Orionilaisille on tärkeää vaalia keskinäistä arvostusta ja kunnioitusta toistemme työtä ja näkemyksiä kohtaan. Muiden kuuntelu ja erilaisten näkökulmien huomioiminen ovat meillä arvokkaita ominaisuuksia saavuttaa tuloksia yhdessä. Työtä teemme tinkimättömällä asenteella, jotta Orion menestyy myös tulevaisuudessa. Lue lisää Orionin arvoista tästä.
Edellytykset
Odotamme sinulta tehtävään soveltuvaa korkeakoulututkintoa (esim. proviisori, DI tai biolääketieteen maisteri). Työskentelet luontevasti sekä itsenäisesti että ryhmässä ja sinulla on hyvät verkostoitumis- ja vuorovaikutustaidot. Kykenet teoreettiseen ja analyyttiseen ajatteluun, mutta olet myös käytännön tekijä, joka toimii reippaasti ja ammattimaisesti saaden asiat tapahtumaan. Olet valmis haastamaan itsesi monipuolisissa tehtävissä ja haluat kehittää itseäsi ja osaamistasi. Hallitset tehtäväkenttäsi silloinkin, kun sinulla on useita työtehtäviä samanaikaisesti tai työtehtävien prioriteetit muuttuvat yllättäen. Kommunikoit sujuvasti suomeksi ja englanniksi.
Lisätietoja ja hakuohjeet
Haethan tehtävää 27.3.2022 mennessä. Aloitamme haastattelut jo hakuprosessin aikana, joten jätäthän hakemuksesi viipymättä.
Lisätietoja tehtävistä antaa Kaisa Hiltunen, Team Leader, puh. 050 966 3652 (ma 21.3. klo 14-14.30 ja to 24.3. klo 9-9.30)
Tehtävään valitulta henkilöltä edellytetään hyväksyttyä terveystarkastusta, joka sisältää myös huumausainetestauksen.
Valitusta henkilöstä tullaan myös teettämään turvallisuusselvitys ennen työsuhteen alkua.
Meitä orionilaisia on 3300 yli 30 maassa ja työskentelemme hyvinkin erilaisissa tehtävissä. Joukostamme löytyy niin tutkijoita ja laborantteja kuin insinöörejä ja IT-asiantuntijoitakin sekä tuotantotyöntekijöitä ja monia muita. Tarjoamme työntekijöillemme monipuolisia sekä vastuullisia tehtäviä aidosti monialaisessa ympäristössä. Kannustamme oman osaamisen kehittämiseen ja tarjoamme mahdollisuuden vaikuttaa työtehtäviin ja oman urapolun luomiseen Orionilla. Me etsimme oman alansa huipputekijöitä, jotka jakavat aidon innostuksemme siihen, mitä teemme.
20.3.2022 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/2972690789
About the job
We at the University of Oulu work as part of the international science community to produce new scientific information and science-based solutions. We are committed to educate future pioneers to build a more sustainable, intelligent, and humane world. Creating new, taking responsibility, and succeeding together are values that build a strong foundation for all our actions. We offer a working environment where individuals can cultivate their skills, do meaningful work, and develop professionally. Our university’s several specialized research and service units enable extensive and diverse development and career opportunities for experts in various fields.
Applications are invited for a full-time Postdoctoral Researcher position until the end of 2023, starting at the earliest on August 1 st , 2022, in a Biocenter Oulu research project headed by Professor Risto Kerkelä and Professor Juhani Junttila in the Research Unit of Biomedicine, Faculty of Medicine.
Our research focuses on molecular mechanisms and genetics regulating development of cardiac fibrosis, heart failure and sudden cardiac death. We study cardiac samples from victims of sudden cardiac death (SCD) to identify genetic factors regulating development of cardiac fibrosis and study the clinical characteristics of mutation carrier family members in order to find applicable clinical markers which can be used to identify subjects at risk for SCD. We will then utilize cell models and genetically engineered mice to study the role of the factors identified in regulating cardiac fibrosis. The Research Unit of Biomedicine offers a lively research environment with strong experience in Ph.D. training, fully equipped up-to-date laboratory space and equipment for physiological analyses of cardiac structure and function.
Requirements
To successfully occupy the position of a Postdoctoral Researcher, the candidate must possess a doctoral degree preferably in the field of medicine, biochemistry, cell biology, or related fields. Degree must have been completed by July 31 st , 2022. Ability to pursue independent research and excellent writing and fluency in English is expected. We also hope the applicant to be familiar with basis of pharmacology and toxicology.
The salary will be initially set on level 5, and later on levels 5 – 6 of the national salary scale for the teaching and research staff of Finnish universities. In addition, a supplementary remuneration is given for personal achievement and performance (max. 50 %). In practice, the salary is roughly 3,500 – 3,800 € per month, depending on the appointee’s qualifications and prior experience. A six-month trial period is applied in the position.
Application
Applications must be submitted using the electronic application form by May 1 st , 2022, 23:59 (Finnish local time), with the following attachments as four separate pdf files:
- Complete CV according to the guidelines of the Finnish Board on Research Integrity (
- List of publications according to the guidelines of the Academy of Finland (
- Motivation letter (max. 1 page) describing prior knowledge and research interests and career plans (1 – 2 pages; max. size limit of the attachment: 2 Mbytes).
- Certificates/Diplomas: Scanned electronic copies of diplomas and transcripts of the records of relevant previous degrees. If the original documents are not in English, Finnish, or Swedish, each document must be accompanied by an official certified translation into English or Finnish (max. size limit of the attachment: 2 Mbytes)
NOTE: Applications sent by email will not be considered.
Other relevant informationThe eligible applicants fitting best in the research profile expected for the position may be invited to an on-site or remote interview. All applicants will be notified when the selection process is completed.
ContactProf. Risto Kerkelä, e-mail: risto.kerkela(at)oulu.fi
About Oulu, Finland
Finland is one of the most livable countries in the world, with a high quality of life, safety, excellent education system, and competitive economy. The Oulu region is home to over 200,000 people making it the largest urban centre in the Nordics and one of the fastest growing regions in northern Finland. Oulu is a combination of beautiful, northern nature, vivid cultural life, and modern technology. Oulu is also known for its highly educated people and friendly, easy-going atmosphere. Living in Oulu is easy – everything is only max. 20 minutes away! Find out more about Oulu:
20.3.2022 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/2970025074
About the job
Do you want to contribute to top quality medical research?
To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.
The research group
The position will be placed in the laboratory of Prof. Eckardt Treuter which conducts pre-clinical research at the crossroads between epigenomics, metabolism, inflammation and disease. The research aims at better understanding how the epigenome controls metabolic and inflammatory pathways in the context of obesity, type 2 diabetes, fatty liver disease and atherosclerosis. Epigenetic alterations that trigger changes in epigenome activity and gene expression are fundamental reprogramming events that are associated with the development of these diseases. However, the underlying regulatory mechanisms, the critical components, and the causal relationship of these associations are currently poorly defined. The laboratory addresses these issues utilizing a multidisciplinary approach,including molecular biology, biochemistry, genomics and epigenomics approaches, in collaboration with clinicians to study human tissue samples.
https://ki.se/en/bionut/epigenetic-mechanisms-underlying-metabolic-inflammatory-diseases-eckardt- treuter
The laboratory is placed in the Department of Biosciences and Nutrition at Karolinska’s South Campus, a creative and open environment.
The doctoral student project and the duties of the doctoral student
The project:
AIM: The purpose of this PhD project is to identify epigenetic signatures in human hepatocytes, with an emphasis on functionally distinct enhancers and silencers, along with exploring epigenetic mechanisms and alterations that underly liver diseases in humans.
RATIONALE: Metabolic and inflammatory signals induce functionally coupled epigenetic and transcriptional alterations in all cell types of the liver that underly severe liver diseases, including non-alcoholic fatty liver disease (NAFLD), steatohepatitis (NASH) and hepatocellular carcinoma (HCC). These alterations are tightly controlled at level of gene expression by so-called cis-regulatory elements including enhancers and silencers, that are also subject to individual genetic variation of disease susceptibility via single nucleotide polymorphisms (SNPs). The regulatory chromatin landscape and disease-associated patient-specific alterations thereof are currently poorly characterized for the human liver, with hepatocytes being the most abundant and crucial cell type.
SIGNIFICANCE: Epigenetic alterations of chromatin states are suspected to contribute to metabolic and inflammatory disease pathways but have not yet been systematically mapped in the human liver. Patient-specific epigenetic signatures may become useful for the diagnosis and therapy of liver diseases (‘record the past and predict the future’).
Duties:
The PhD student will establish and manipulate human hepatocyte cultures in 2D and 3D. These models will be used (1) to identify candidate enhancers and silencers and alterations in response to different disease-relevant signaling conditions, (2) to uncover molecular features that distinguish enhancers and silencers and underly signaling-induced alterations, and (3) to determine individual epigenetic signatures from healthy vs. diseased livers to identify disease-associated alterations. Integrated analysis of disease-linked SNPs will explore how genetic and epigenetic alterations influence each other in hepatocytes. Candidate causal alterations will be functionally characterized using in our laboratory established techniques (PMID: 30975991; PMID: 30825152; PMID: 33503407).
What do we offer?
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.
Eligibility Requirements For Doctoral Education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.
It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.
- General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:
- have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
- have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
- have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*
Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.
- If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.
- Specific eligibility requirement
You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:
- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.
Follow the instructions on the web page English language requirements for doctoral education.
Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.
- and (B) can only be certified by the documentation requirement for doctoral education.
Skills And Personal Qualities
We are seeking a highly motivated and talented individual with a degree in nutritional science, biomedicine, biochemistry, genetics or related fields. A solid wet lab experience in the isolation and cultivation of primary human hepatocytes from healthy and diseased liver tissues (cancer, steatosis, cirrhosis), along with a strong theoretical background in human liver physiology and disease, is required for this position. This includes 2D and 3D hepatocyte cultures, functional assessments and viability testing, sample preparation and standard methods for RNA, DNA, chromatin and protein analysis. Since the focus of this PhD project is on human liver pathways and clinical relevance, experience with rodent liver models is not required. Desired is further someone who is already familiar with working in a clinical environment, BSL-2 laboratory, GMP, in organizing, handling and biobanking patient samples, and in writing ethical permit and biobank applications. Previous experience in data processing, compilation and statistical analysis is an additional merit for this position.
The successful candidate is driven by a great curiosity for biomedical research aimed at exploring epigenetic mechanisms contributing to liver dysfunction in human diseases, willing to tackle challenging tasks with a problem-solving and positive mindset, has excellent written and oral communication skills, and can work focused both independently and as a cooperative team player.
Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.
Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.
Your application must contain the following documents:
- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)
Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.
Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.
All applicants will be informed when the recruitment is completed.
Want to make a difference? Join us and contribute to better health for all
20.3.2022 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/2971536301
Offer Description
The laboratory of Associate Professor Pekka Katajisto at the department of Cell and Molecular Biology, Karolinska Institutet, Sweden, and HiLIFE, University of Helsinki, Finland, is looking for two postdoctoral researchers in the field of Stem Cell Biology and Metabolism.
Katajisto group (www.katajisto-lab.com) is part of the Centre of Excellence in Stem Cell Metabolism, MetaStem, and studies stem cell intrinsic and extrinsic mechanisms of tissue renewal and aging. We have discovered for example how the age-induced decline in tissue regeneration can result from alterations in niche cells (Pentinmikko, Nature 2019), how the niche signals are highjacked by tumor cells (Flanagan, Nature 2021), and how asymmetric inheritance of organelles guides stem cell fate metabolically (Döhla, Nat Cell Biol 2022).
The postdoctoral projects will focus on the interplay between stem cell metabolism and niche biology. Candidates are also encouraged to start new projects and research directions. Applicants with a doctoral degree, a strong background in cell biology and an interest in cellular metabolism are encouraged to apply. Prior experience with animal work, primary stem cell systems and/or metabolism is considered a strength. Applicants must be able to work as part of a team as well as independently, have good social skills and communication skills in English.
The appointment will be for 2 years with the possibility of continuation. A trial period of 6 months will be applied. The monthly starting salary will be determined according to the salary system at the employment unit.
Only applications submitted through the official application systems will be considered.
To apply, please submit your application by 11.5.2022.
Applications should include
A motivation letter, clearly stating your interests and why you consider yourself a good candidate for the position
CV including publication list
One or more reference letters
To apply for a position in the Helsinki lab, please submit your application, together with the required attachments, through the University of Helsinki electronic recruitment system by clicking on the ‘Apply for job’ button below. Internal applicants (i.e., current employees of the University of Helsinki) submit their applications through the SAP Fiori portal.
To apply for a position in the Stockholm lab, go here: https://ki.se/en/about/available-positions-at-kihttps://ki.se/en/about/a…
Web sites
www.katajisto-lab.com
www.helsinki.fi/metastem
Social media
Twitter: @KatajistoLab @PekkaKatajisto
Facebook: @katajistoagingteam
Information About The Host Institutes
University of Helsinki
The University of Helsinki is the largest university in Finland and one of the leading multidisciplinary universities in the world. International experts working at the University are also attracted by Helsinki’s unique atmosphere and Nordic lifestyle. The University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Further information at www.helsinki.fi/en/about-us/careers. Helsinki Institute of Life Science (HiLIFE) supports high quality life science research across the University campuses and faculties. HiLIFE builds on existing strengths and new recruits and partnerships to create an attractive international environment for researchers to solve grand challenges in health, food, and environment. Institute of Biotechnology (BI) is an internationally renowned research institute with an inclusive and curiosity-driven working culture. Using cutting-edge infrastructures we advance breakthrough discoveries, technology development and innovations. https://www2.helsinki.fi/en/hilife-institute-of-biotechnology
Karolinska Institutet
Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care. https://staff.ki.se/careers-at-ki
Due date
11.05.2022 23:59 EEST
20.3.2022 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/2975796411
About the job
Job Description
About This Role
This is a part-time limited contract position in the Human Genetics group that will support the R&D organization to optimally leverage a large-scale biobank initiative that Biogen is investing in, FinnGen (www.finngen.fi). You will report to the Sr Medical Director, Statistical Genetics.
What You’ll Do
- Educate/train employees on resources and tools available in FinnGen and how to best access/utilize them.
- Support the Biogen Human Genetics group with targeted look-ups in (green and red sandbox) FinnGen data (e.g. to support drug target assessments in Human Molecular Reviews).
- Act as an interface to FinBB for ensuring the success of Biogen FinnGen spin-off studies.
- Advise the Biogen Human Genetics group on how to best organize and communicate internal/external human datasets.
Who You Are
You have a strong experience in either industry or academic research settings. You know how to apply your knowledge to train people on resources and tools and how to best access/utilize them. As a person you take ownership of commitments and goals.
Qualifications
Required Skills
- Minimum M.Sc. with 7+ years of work experience in either industry or academic research settings.
- Deeply embedded in generating software and/or algorithms to leverage human genetic and/or biobank data.
- Understanding of the drug target discovery process.
- Worked with FinnGen individual-level human data.
Why Biogen?
Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.
Additional Information
This is a part-time 6 months contract position in the Human Genetics group that will support the R&D organization to optimally leverage a large-scale biobank initiative that Biogen is investing in, FinnGen (www.finngen.fi). You will report to the Sr Medical Director, Statistical Genetics.
20.3.2022 | Avoimet työpaikat
https://duunitori.fi/tyopaikat/tyo/laboratorioteknikko-stse-14636267?utm_source=loimu&utm_medium=email
Työpaikkakuvaus
Professori Päivi Ojalan tutkimusryhmä Helsingin yliopiston lääketieteellisen tiedekunnan Tutkimusohjelmayksiköstä etsii
LABORATORIOTEKNIKKOA
määräaikaiseen tehtävään (sijaisuus) ajalle 1.5.2022 – 31.5.2023.
Ryhmässämme tehdään monipuolista syöpäbiologian tutkimusta ja tutkimuskohteitamme ovat ihmisen syöpävirukset, syövän leviäminen eli metastaasi sekä immunoterapiat.
Lisätietoa ryhmämme toiminnasta löydät sivulta: https://www2.helsinki.fi/en/researchgroups/cancer-cell-biology.
Laboratorioteknikon työ sisältää monipuolisesti molekyyli- ja solubiologian eri metodien käyttöä tutkimustyön avustamisessa. Lisäksi laboratoriohankintojen koordinointi, tarjouspyyntöjen hoitaminen ja ostolaskujen tarkistaminen ovat osa työtehtäviä. Päivittäisten toimintojen kannalta olennaisista tarvikkeista ja materiaaleista huolehtiminen ja laboratorion siisteyden ylläpitäminen kuuluvat myös työtehtäviin. Edellä mainittujen lisäksi tehtävään kuuluu tutkimusprojekteihin osallistuminen kokeellisen tutkimustyön muodossa.
Tehtävään valittavalla tulee olla laboratorioalan tutkinto tai muu vastaava tutkinto. Tehtävän hoitaminen edellyttää hyvää suomen ja englannin kielen taitoa, sekä valmiutta niin itsenäiseen kuin ryhmässä työskentelyyn ja joustavuutta. Eduksi katsomme aiemman kokemuksen akateemisessa tutkimusryhmässä työskentelystä.
Tehtävän palkkaus on noin 2300-2500 e/kk riippuen valittavan henkilön kokemuksesta ja ansioista. Tehtävä täytetään kuuden kuukauden koeajalla.
WWW-osoite http://www.helsinki.fi
Yhteystiedot Professori Päivi Ojala, paivi.ojala (at) helsinki.fi.
Työpaikan osoite Haartmaninkatu 8, 00290 HELSINKI
Työ alkaa 1.5.2022
Työaika kokoaikatyö
Työn kesto yli 12 kuukautta
Haku päättyy 05.04.2022 klo 23:59
Jätä hakemus Lähetä hakemuksesi Helsingin yliopiston sähköiseen rekrytointijärjestelmään alla olevan linkin kautta. Liitäthän hakemukseesi hakemuskirjeen lisäksi myös ansioluettelosi.
Ilmoitus jätetty 18.03.2022
Ilmoitusnumero 11292315